Dopamine deficiency in the weaver mutant mouse: An animal model of olivopontocerebellar atrophy

H. Chou, N. Ogawa, M. Asanuma, H. Hirata, A. Mori

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The dopamine system in weaver mutant mice, a model of cerebellar atrophy, was studied. Dopamine levels of 6-week-old weaver mice were 37%, 44%, 34%, and 41% of levels in age-matched controls in the cerebral cortex, hippocampus, septal region and striatum, respectively. Noradrenaline levels did not differ from controls. This study shows that weaver mice have specific deficiencies in the dopamine system.

Original languageEnglish
Pages (from-to)117-120
Number of pages4
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume74
Issue number1
Publication statusPublished - Nov 7 1991

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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