Donor lymphocyte transfusion for the treatment of Epstein-Barr virus-associated lymphoproliferative disorder of the brain

K. Nagafuji, T. Eto, S. Hayashi, K. Oshima, Y. Maeda, H. Gondo, T. Inamura, Y. Niho

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

EBV-associated lymphoproliferative disorder (LPD) is a rare but serious complication in marrow transplant recipients. A 31-year-old Japanese woman in the second chronic phase of CML received an allogeneic BMT from her HLA 2-locus-incompatible 62-year-old father. Around day +200, she developed EBV-LPD of the right parieto-temporal lobe which caused slowly progressive left hemiparesis. Two courses of donor lymphocyte transfusions (DLT) of 106 CD3+ T cells/kg of body weight failed to suppress her central nervous system (CNS) EBV-LPD. The patient died of recurrent blastic crisis of CML. This case suggests that DLT may be ineffective for the treatment of CNS EBV-LPD.

Original languageEnglish
Pages (from-to)1155-1158
Number of pages4
JournalBone Marrow Transplantation
Volume21
Issue number11
DOIs
Publication statusPublished - Jan 1 1998

Keywords

  • Central nervous system
  • Donor lymphocyte transfusion
  • Epstein-Barr virus-associated lymphoproliferative disorder

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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