Donor lymphocyte transfusion for the treatment of Epstein-Barr virus-associated lymphoproliferative disorder of the brain

K. Nagafuji, T. Eto, S. Hayashi, K. Oshima, Yoshinobu Maeda, H. Gondo, T. Inamura, Y. Niho

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

EBV-associated lymphoproliferative disorder (LPD) is a rare but serious complication in marrow transplant recipients. A 31-year-old Japanese woman in the second chronic phase of CML received an allogeneic BMT from her HLA 2-locus-incompatible 62-year-old father. Around day +200, she developed EBV-LPD of the right parieto-temporal lobe which caused slowly progressive left hemiparesis. Two courses of donor lymphocyte transfusions (DLT) of 106 CD3+ T cells/kg of body weight failed to suppress her central nervous system (CNS) EBV-LPD. The patient died of recurrent blastic crisis of CML. This case suggests that DLT may be ineffective for the treatment of CNS EBV-LPD.

Original languageEnglish
Pages (from-to)1155-1158
Number of pages4
JournalBone Marrow Transplantation
Volume21
Issue number11
Publication statusPublished - 1998

Fingerprint

Lymphocyte Transfusion
Lymphoproliferative Disorders
Human Herpesvirus 4
Tissue Donors
Brain
Central Nervous System
Paresis
Temporal Lobe
Therapeutics
Fathers
Bone Marrow
Body Weight
T-Lymphocytes

Keywords

  • Central nervous system
  • Donor lymphocyte transfusion
  • Epstein-Barr virus-associated lymphoproliferative disorder

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Donor lymphocyte transfusion for the treatment of Epstein-Barr virus-associated lymphoproliferative disorder of the brain. / Nagafuji, K.; Eto, T.; Hayashi, S.; Oshima, K.; Maeda, Yoshinobu; Gondo, H.; Inamura, T.; Niho, Y.

In: Bone Marrow Transplantation, Vol. 21, No. 11, 1998, p. 1155-1158.

Research output: Contribution to journalArticle

Nagafuji, K, Eto, T, Hayashi, S, Oshima, K, Maeda, Y, Gondo, H, Inamura, T & Niho, Y 1998, 'Donor lymphocyte transfusion for the treatment of Epstein-Barr virus-associated lymphoproliferative disorder of the brain', Bone Marrow Transplantation, vol. 21, no. 11, pp. 1155-1158.
Nagafuji, K. ; Eto, T. ; Hayashi, S. ; Oshima, K. ; Maeda, Yoshinobu ; Gondo, H. ; Inamura, T. ; Niho, Y. / Donor lymphocyte transfusion for the treatment of Epstein-Barr virus-associated lymphoproliferative disorder of the brain. In: Bone Marrow Transplantation. 1998 ; Vol. 21, No. 11. pp. 1155-1158.
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AU - Maeda, Yoshinobu

AU - Gondo, H.

AU - Inamura, T.

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