TY - JOUR
T1 - Does tumor type affect local control by radiofrequency ablation in the lungs?
AU - Hiraki, Takao
AU - Gobara, Hideo
AU - Mimura, Hidefumi
AU - Sano, Yoshifumi
AU - Tsuda, Toshihide
AU - Iguchi, Toshihiro
AU - Fujiwara, Hiroyasu
AU - Kishi, Ryotaro
AU - Matsui, Yusuke
AU - Kanazawa, Susumu
PY - 2010/4
Y1 - 2010/4
N2 - Objective: : To retrospectively evaluate the effect of tumor type on local control by radiofrequency ablation in the lungs. Materials and methods: : This study included 252 lung tumors (mean size, 13.5 mm) in 105 patients (73 men and 32 women; mean age, 66.6 years) who underwent radiofrequency ablation with a multitined expandable electrode. Those tumors comprised five tumor types: primary lung cancer (n = 35) and pulmonary metastases from colorectal cancer (n = 117), lung cancer (n = 23), renal cell carcinoma (n = 49), and hepatocellular carcinoma (n = 28). Local control was evaluated with contrast-enhanced computed tomography. The overall local control rates were estimated as well as those for each tumor type using the Kaplan-Meier analysis. Local control rates for a given tumor type were compared with those for the four other types. Then, multivariate multilevel analysis was performed using the variables of tumor type, tumor size, contact with a vessel or bronchus, and procedure period. Results: : The overall local control rates were 97%, 86%, 81%, and 76% at 6, 12, 18, and 24 months, respectively. Local control rates varied among the tumor types, and metastatic colorectal cancer showed significantly (P = .023) higher local control rates than those of the four other types. However, multivariate analysis indicated that the relative risk of local progression for a given tumor type was comparable to the risks for the four other types. Conclusion: : Tumor type per se did not significantly influence local control.
AB - Objective: : To retrospectively evaluate the effect of tumor type on local control by radiofrequency ablation in the lungs. Materials and methods: : This study included 252 lung tumors (mean size, 13.5 mm) in 105 patients (73 men and 32 women; mean age, 66.6 years) who underwent radiofrequency ablation with a multitined expandable electrode. Those tumors comprised five tumor types: primary lung cancer (n = 35) and pulmonary metastases from colorectal cancer (n = 117), lung cancer (n = 23), renal cell carcinoma (n = 49), and hepatocellular carcinoma (n = 28). Local control was evaluated with contrast-enhanced computed tomography. The overall local control rates were estimated as well as those for each tumor type using the Kaplan-Meier analysis. Local control rates for a given tumor type were compared with those for the four other types. Then, multivariate multilevel analysis was performed using the variables of tumor type, tumor size, contact with a vessel or bronchus, and procedure period. Results: : The overall local control rates were 97%, 86%, 81%, and 76% at 6, 12, 18, and 24 months, respectively. Local control rates varied among the tumor types, and metastatic colorectal cancer showed significantly (P = .023) higher local control rates than those of the four other types. However, multivariate analysis indicated that the relative risk of local progression for a given tumor type was comparable to the risks for the four other types. Conclusion: : Tumor type per se did not significantly influence local control.
KW - Local recurrence
KW - Lung cancer
KW - Lung metastasis
KW - Radiofrequency ablation
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U2 - 10.1016/j.ejrad.2009.01.026
DO - 10.1016/j.ejrad.2009.01.026
M3 - Article
C2 - 19231125
AN - SCOPUS:77950053523
VL - 74
SP - 136
EP - 141
JO - European Journal of Radiology
JF - European Journal of Radiology
SN - 0720-048X
IS - 1
ER -