Does tumor type affect local control by radiofrequency ablation in the lungs?

Takao Hiraki, Hideo Gobara, Hidefumi Mimura, Yoshifumi Sano, Toshihide Tsuda, Toshihiro Iguchi, Hiroyasu Fujiwara, Ryotaro Kishi, Yusuke Matsui, Susumu Kanazawa

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Abstract

Objective: : To retrospectively evaluate the effect of tumor type on local control by radiofrequency ablation in the lungs. Materials and methods: : This study included 252 lung tumors (mean size, 13.5 mm) in 105 patients (73 men and 32 women; mean age, 66.6 years) who underwent radiofrequency ablation with a multitined expandable electrode. Those tumors comprised five tumor types: primary lung cancer (n = 35) and pulmonary metastases from colorectal cancer (n = 117), lung cancer (n = 23), renal cell carcinoma (n = 49), and hepatocellular carcinoma (n = 28). Local control was evaluated with contrast-enhanced computed tomography. The overall local control rates were estimated as well as those for each tumor type using the Kaplan-Meier analysis. Local control rates for a given tumor type were compared with those for the four other types. Then, multivariate multilevel analysis was performed using the variables of tumor type, tumor size, contact with a vessel or bronchus, and procedure period. Results: : The overall local control rates were 97%, 86%, 81%, and 76% at 6, 12, 18, and 24 months, respectively. Local control rates varied among the tumor types, and metastatic colorectal cancer showed significantly (P = .023) higher local control rates than those of the four other types. However, multivariate analysis indicated that the relative risk of local progression for a given tumor type was comparable to the risks for the four other types. Conclusion: : Tumor type per se did not significantly influence local control.

Original languageEnglish
Pages (from-to)136-141
Number of pages6
JournalEuropean Journal of Radiology
Volume74
Issue number1
DOIs
Publication statusPublished - Apr 2010

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Keywords

  • Local recurrence
  • Lung cancer
  • Lung metastasis
  • Radiofrequency ablation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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