Does pretreatment with lansoprazole influence Helicobacter pylori eradication rate and quality of life?

Masafumi Inoue, Hiroyuki Okada, Shinichiro Hori, Yoshiro Kawahara, Seiji Kawano, Ryuta Takenaka, Tatsuya Toyokawa, Yasuhiro Onishi, Yasushi Shiratori, Kazuhide Yamamoto

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Background/Aims: It is controversial whether pretreatment with a proton pump inhibitor (PPI) before Helicobacter pylori eradication treatment decreases the eradication rate. To determine the effects of pretreatment with lansoprazole alone, followed by an H. pylori eradication regimen (lansoprazole 30 mg, amoxicillin 750 mg and clarithromycin 200 mg twice daily for 1 week), on the eradication rate and quality of life (QoL) of the patient. Methods: Patients with H. pylori-positive peptic ulcer were randomly assigned to two groups. The patients received either lansoprazole (30 mg) once daily for 6-8 weeks before H. pylori eradication (group A), or eradication treatment and then lansoprazole (30 mg) for 6-8 weeks (group B). To assess the QoL of the patients, the Gastrointestinal Symptom Rating Scale (GSRS) questionnaire was evaluated. Results: A total of 116 patients were enrolled. The cure rates were 78.9% in group A and 78.0% in group B. In both groups, GSRS analysis showed a significant improvement of the overall GSRS score at the assessment of eradication efficacy, compared to baseline; there was no difference between the groups. Conclusion: With this H. pylori eradication regimen, there was no difference in the cure rates and QoL associated with PPI pretreatment.

Original languageEnglish
Pages (from-to)218-222
Number of pages5
Issue number4
Publication statusPublished - Apr 2010


  • Eradication rate
  • Helicobacter pylori
  • Proton pump inhibitor
  • Quality of life

ASJC Scopus subject areas

  • Gastroenterology


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