Does HMGB1 predict occult neck lymph node metastasis in early tongue carcinoma? A case-control study of 26 patients

H. Hanakawa, Y. Orita, Yasuharu Sato, M. Takeuchi, Soshi Takao, K. Ohno, T. Kohno, N. Iwaki, Hidenori Marunaka, R. Tamamura, Masahiro Nishibori, Hitoshi Nagatsuka, Kazunori Nishizaki, Tadashi Yoshino

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: This study examined whether the occurrence of late neck metastasis in early tongue squamous cell carcinoma can be predicted by evaluating HMGB1 (high mobility group box 1) expression in the primary lesion. Methods: A case-control study was conducted. The cases comprised 10 patients with late neck metastasis. The controls consisted of 16 patients without recurrence. All were examined immunohistochemically for HMGB1 protein expression. The odds ratio for late neck metastasis in relation to HMGB1 was estimated. Results: Results for HMGB1 were dichotomised into positive staining scores (score, 5-7) and negative scores (0-4). Six cases (60 per cent) and four controls (25 per cent) were HMGB1-positive. Although no significant result was seen, compared with HMGB1-negative patients the odds ratio for late neck metastasis in HMGB1-positive patients was 3.8 (95 per cent confidence interval, 0.6-26.5) after adjusting for other factors. Conclusion: In the present study, immunohistochemical study of HMGB1 in early tongue squamous cell carcinoma did not appear to be very useful for predicting occult neck metastasis. Further study is necessary to clarify the relationship between HMGB1 expression and late neck metastasis in early tongue squamous cell carcinoma.

Original languageEnglish
Pages (from-to)926-931
Number of pages6
JournalJournal of Laryngology and Otology
Volume128
Issue number10
DOIs
Publication statusPublished - Oct 2 2014

Fingerprint

Tongue
Case-Control Studies
Neck
Lymph Nodes
Neoplasm Metastasis
Carcinoma
Squamous Cell Carcinoma
Odds Ratio
HMGB1 Protein
Confidence Intervals
Staining and Labeling
Recurrence

Keywords

  • Carcinoma
  • HMGB1
  • Metastasis
  • Tongue

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Medicine(all)

Cite this

Does HMGB1 predict occult neck lymph node metastasis in early tongue carcinoma? A case-control study of 26 patients. / Hanakawa, H.; Orita, Y.; Sato, Yasuharu; Takeuchi, M.; Takao, Soshi; Ohno, K.; Kohno, T.; Iwaki, N.; Marunaka, Hidenori; Tamamura, R.; Nishibori, Masahiro; Nagatsuka, Hitoshi; Nishizaki, Kazunori; Yoshino, Tadashi.

In: Journal of Laryngology and Otology, Vol. 128, No. 10, 02.10.2014, p. 926-931.

Research output: Contribution to journalArticle

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abstract = "Objective: This study examined whether the occurrence of late neck metastasis in early tongue squamous cell carcinoma can be predicted by evaluating HMGB1 (high mobility group box 1) expression in the primary lesion. Methods: A case-control study was conducted. The cases comprised 10 patients with late neck metastasis. The controls consisted of 16 patients without recurrence. All were examined immunohistochemically for HMGB1 protein expression. The odds ratio for late neck metastasis in relation to HMGB1 was estimated. Results: Results for HMGB1 were dichotomised into positive staining scores (score, 5-7) and negative scores (0-4). Six cases (60 per cent) and four controls (25 per cent) were HMGB1-positive. Although no significant result was seen, compared with HMGB1-negative patients the odds ratio for late neck metastasis in HMGB1-positive patients was 3.8 (95 per cent confidence interval, 0.6-26.5) after adjusting for other factors. Conclusion: In the present study, immunohistochemical study of HMGB1 in early tongue squamous cell carcinoma did not appear to be very useful for predicting occult neck metastasis. Further study is necessary to clarify the relationship between HMGB1 expression and late neck metastasis in early tongue squamous cell carcinoma.",
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