Abstract
We attempted to determine whether docosahexaenoic acid (DHA)-induced apoptosis is mediated via the Bax-mediated pathway in human myeloid leukemia HL-60 cells. DHA-induced apoptosis was confirmed by morphological analysis and caspase-3 activation. But, cyclosporin A (CsA), an inhibitor of mitochondrial permeability transition (MPT), did not inhibit DHA-induced Bax translocation to mitochondria or caspase-3 activation. These data suggest that DHA can induce apoptosis via the Bax-independent pathway.
Original language | English |
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Pages (from-to) | 2415-2417 |
Number of pages | 3 |
Journal | Bioscience, Biotechnology and Biochemistry |
Volume | 68 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 2004 |
Keywords
- Apoptosis
- Bax
- Caspase-3
- Docosahexaenoic acid (DHA)
- HL-60 cells
ASJC Scopus subject areas
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry