Docosahexaenoic acid induces apoptosis via the bax-independent pathway in HL-60 cells

Yoshie Miura, Keigo Takahara, Yoshiyuki Murata, Kozo Utsumi, Mikiro Tada, Kyoya Takahata

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We attempted to determine whether docosahexaenoic acid (DHA)-induced apoptosis is mediated via the Bax-mediated pathway in human myeloid leukemia HL-60 cells. DHA-induced apoptosis was confirmed by morphological analysis and caspase-3 activation. But, cyclosporin A (CsA), an inhibitor of mitochondrial permeability transition (MPT), did not inhibit DHA-induced Bax translocation to mitochondria or caspase-3 activation. These data suggest that DHA can induce apoptosis via the Bax-independent pathway.

Original languageEnglish
Pages (from-to)2415-2417
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume68
Issue number11
DOIs
Publication statusPublished - Nov 1 2004

Keywords

  • Apoptosis
  • Bax
  • Caspase-3
  • Docosahexaenoic acid (DHA)
  • HL-60 cells

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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