Docosahexaenoic acid induces apoptosis via the bax-independent pathway in HL-60 cells

Yoshie Miura; Keigo Takahara; Yoshiyuki Murata; Kozo Utsumi; Mikiro Tada; Kyoya Takahata

doi:10.1271/bbb.68.2415

Docosahexaenoic acid induces apoptosis via the bax-independent pathway in HL-60 cells

Yoshie Miura, Keigo Takahara, Yoshiyuki Murata, Kozo Utsumi, Mikiro Tada, Kyoya Takahata

Research output: Contribution to journal › Article

18 Citations (Scopus)

Abstract

We attempted to determine whether docosahexaenoic acid (DHA)-induced apoptosis is mediated via the Bax-mediated pathway in human myeloid leukemia HL-60 cells. DHA-induced apoptosis was confirmed by morphological analysis and caspase-3 activation. But, cyclosporin A (CsA), an inhibitor of mitochondrial permeability transition (MPT), did not inhibit DHA-induced Bax translocation to mitochondria or caspase-3 activation. These data suggest that DHA can induce apoptosis via the Bax-independent pathway.

Original language	English
Pages (from-to)	2415-2417
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	68
Issue number	11
DOIs	https://doi.org/10.1271/bbb.68.2415
Publication status	Published - Nov 2004

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Keywords

Apoptosis
Bax
Caspase-3
Docosahexaenoic acid (DHA)
HL-60 cells

ASJC Scopus subject areas

Bioengineering
Biotechnology
Biochemistry
Biochemistry, Genetics and Molecular Biology(all)
Chemistry (miscellaneous)
Applied Microbiology and Biotechnology
Food Science

Cite this

Miura, Y., Takahara, K., Murata, Y., Utsumi, K., Tada, M., & Takahata, K. (2004). Docosahexaenoic acid induces apoptosis via the bax-independent pathway in HL-60 cells. Bioscience, Biotechnology and Biochemistry, 68(11), 2415-2417. https://doi.org/10.1271/bbb.68.2415

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Access to Document

10.1271/bbb.68.2415