DNA methylation of multiple genes and clinicopathological relationship of non-small cell lung cancers

Tetsuro Hanabata, Kazunori Tsukuda, Shinichi Toyooka, Masaaki Yano, Motoi Aoe, Itaru Nagahiro, Yoshifumi Sano, Hiroshi Date, Nobuyoshi Shimizu

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23 Citations (Scopus)

Abstract

Aberrant methylation of 5′ CpG islands is thought to play an important role in the inactivation of tumor suppressor genes in several types of cancers. In non-small cell lung cancer (NSCLC), several genes are known to be frequently methylated and the correlation of their methylation with clinical features has been studied. We determined the methylation of p16, CDH13 and RAR-β which were reported to be methylated frequently in NSCLCs and HPP-1 which was known to be methylated in other types of cancers. The correlation between methylation and clinicopathological features were examined. The frequencies of methylation in NSCLCs were 20% for p16, 37% for CDH13, 34% for RAR-β, and 13% for HPP1. The methylation of p16 is correlated with smoking history and methylation of HPP1 was significantly more frequent in adenocarcinomas than in squamous cell carcinomas. This is the first description of aberrant methylation of the HPP1 gene in lung cancers and our data support the previous reports on methylation in NSCLCs and association with smoking.

Original languageEnglish
Pages (from-to)177-180
Number of pages4
JournalOncology reports
Volume12
Issue number1
DOIs
Publication statusPublished - Jul 2004

Keywords

  • Clinicopathology
  • DNA methylation
  • Non-small cell lung cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Hanabata, T., Tsukuda, K., Toyooka, S., Yano, M., Aoe, M., Nagahiro, I., Sano, Y., Date, H., & Shimizu, N. (2004). DNA methylation of multiple genes and clinicopathological relationship of non-small cell lung cancers. Oncology reports, 12(1), 177-180. https://doi.org/10.3892/or.12.1.177