DNA copy number gains in malignant pleural mesothelioma

Masashi Furukawa, Shinichi Toyooka, Tatsuro Hayashi, Hiromasa Yamamoto, Nobukazu Fujimoto, Junichi Soh, Shinsuke Hashida, Kazuhiko Shien, Hiroaki Asano, Keisuke Aoe, Kazunori Okabe, Harvey I. Pass, Kazunori Tsukuda, Takumi Kishimoto, Shinichiro Miyoshi

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Abstract

Malignant pleural mesothelioma (MPM) is a highly aggressive tumor with an extremely poor prognosis. The incidence of MPM is increasing as a result of widespread exposure to asbestos. The molecular pathogenesis of MPM remains unclear. The present study analyzed the frequency of various genomic copy number gains (CNGs) in MPM using reverse transcription‑quantitative polymerase chain reaction. A total of 83 primary MPMs and 53 primary lung adenocarcinomas were analyzed to compare the CNGs of EGFR, KRAS, MET, FGFR1 and SOX2. In MPM, the CNGs of EGFR, KRAS, MET, FGFR1 and SOX2 were detected in 12 (14.5%), 8 (9.6%), 5 (6.0%), 4 (4.8%) and 1 (1.2%) of the samples, respectively. In lung adenocarcinomas, the CNGs of EGFR, KRAS, MET, FGFR1 and SOX2 were detected in 21 (39.6%), 12 (22.6%), 5 (9.4%), 10 (18.9%) and 0 (0.0%) of the samples, respectively. The CNGs of EGFR, KRAS and FGFR1 were significantly less frequent in the MPMs compared with the lung adenocarcinomas (P=0.0018, 0.048 and 0.018, respectively). Overall, the MPMs exhibited these CNGs less frequently compared with the lung adenocarcinomas (P=0.0002). The differences in CNGs between the two tumor types suggested that they are genetically different.

Original languageEnglish
Pages (from-to)3274-3278
Number of pages5
JournalOncology Letters
Volume10
Issue number5
DOIs
Publication statusPublished - Nov 1 2015

Keywords

  • Copy number
  • Lung adenocarcinoma
  • Malignant pleural mesothelioma
  • Reverse transcription-quantitative polymerase chain reaction

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Furukawa, M., Toyooka, S., Hayashi, T., Yamamoto, H., Fujimoto, N., Soh, J., Hashida, S., Shien, K., Asano, H., Aoe, K., Okabe, K., Pass, H. I., Tsukuda, K., Kishimoto, T., & Miyoshi, S. (2015). DNA copy number gains in malignant pleural mesothelioma. Oncology Letters, 10(5), 3274-3278. https://doi.org/10.3892/ol.2015.3652