Division of labor in the honey bee (Apis mellifera): The role of tyramine β-hydroxylase

Herman K. Lehman, David J. Schulz, Andrew B. Barron, Lydia Wraight, Chris Hardison, Sandra Whitney, Hideaki Takeuchi, Rajib K. Paul, Gene E. Robinson

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The biogenic amine octopamine (OA) is involved in the regulation of honey bee behavioral development; brain levels are higher in foragers than bees working in the hive, especially in the antennal lobes, and treatment causes precocious foraging. We measured brain mRNA and protein activity of tyramine β-hydroxylase (Tβh), an enzyme vital for OA synthesis, in order to begin testing the hypothesis that this enzyme is responsible for the rising levels of OA during honey bee behavioral development. Brain OA levels were greater in forager bees than in bees engaged in brood care, as in previous studies, but Tβh activity was not correlated with bee behavior. Tβh mRNA levels, however, did closely track OA levels during behavioral development, and Tβh mRNA was localized to previously identified octopaminergic neurons in the bee brain. Our results show that the transcription of this neurotransmitter synthetic enzyme is associated with regulation of social behavior in honey bees, but other factors may be involved.

Original languageEnglish
Pages (from-to)2774-2784
Number of pages11
JournalJournal of Experimental Biology
Volume209
Issue number14
DOIs
Publication statusPublished - Jul 2006
Externally publishedYes

Fingerprint

octopamine
polyethism
Tyramine
Honey
tyramine
Bees
labor division
honey
Mixed Function Oxygenases
Apis mellifera
bee
honey bees
Octopamine
Apoidea
brain
enzymes
Brain
antennal lobe
enzyme
brood rearing

Keywords

  • Apis mellifera
  • Octopamine
  • Tyramine
  • Tyramine beta-hydroxylase

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)

Cite this

Lehman, H. K., Schulz, D. J., Barron, A. B., Wraight, L., Hardison, C., Whitney, S., ... Robinson, G. E. (2006). Division of labor in the honey bee (Apis mellifera): The role of tyramine β-hydroxylase. Journal of Experimental Biology, 209(14), 2774-2784. https://doi.org/10.1242/jeb.02296

Division of labor in the honey bee (Apis mellifera) : The role of tyramine β-hydroxylase. / Lehman, Herman K.; Schulz, David J.; Barron, Andrew B.; Wraight, Lydia; Hardison, Chris; Whitney, Sandra; Takeuchi, Hideaki; Paul, Rajib K.; Robinson, Gene E.

In: Journal of Experimental Biology, Vol. 209, No. 14, 07.2006, p. 2774-2784.

Research output: Contribution to journalArticle

Lehman, HK, Schulz, DJ, Barron, AB, Wraight, L, Hardison, C, Whitney, S, Takeuchi, H, Paul, RK & Robinson, GE 2006, 'Division of labor in the honey bee (Apis mellifera): The role of tyramine β-hydroxylase', Journal of Experimental Biology, vol. 209, no. 14, pp. 2774-2784. https://doi.org/10.1242/jeb.02296
Lehman HK, Schulz DJ, Barron AB, Wraight L, Hardison C, Whitney S et al. Division of labor in the honey bee (Apis mellifera): The role of tyramine β-hydroxylase. Journal of Experimental Biology. 2006 Jul;209(14):2774-2784. https://doi.org/10.1242/jeb.02296
Lehman, Herman K. ; Schulz, David J. ; Barron, Andrew B. ; Wraight, Lydia ; Hardison, Chris ; Whitney, Sandra ; Takeuchi, Hideaki ; Paul, Rajib K. ; Robinson, Gene E. / Division of labor in the honey bee (Apis mellifera) : The role of tyramine β-hydroxylase. In: Journal of Experimental Biology. 2006 ; Vol. 209, No. 14. pp. 2774-2784.
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