Diversified expression patterns of autotaxin, a gene for phospholipid-generating enzyme during mouse and chicken development

Hideyo Ohuchi, Yasunori Hayashibaral, Hironao Matsuda, Motoyoshi Onoi, Masayuki Mitsumori, Masayuki Tanaka, Junken Aoki, Hiroyuki Arai, Sumihare Noji

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Autotaxin (ATX), or nucleotide pyrophosphatase-phosphodiesterase 2, is a secreted lysophospholipase D that generates bioactive phospholipids that act on G protein-coupled receptors. Here we show the expression patterns of the ATX gene in mouse and chicken embryos. ATX has a dynamic spatial and temporal expression pattern in both species and the expression domains during neural development are quite distinct from each other. Murine ATX (mATX) is expressed immediately rostral to the midbrain-hindbrain boundary, whereas chicken ATX (cATX) is expressed in the diencephalon and later in the parencephalon- symencephalon boundary. In the neural tube, cATX is expressed in the alar plate in contrast to mATX in the floor plate. ATX is also expressed in the hindbrain and various organ primordia such as face anlagen and skin appendages of the mouse and chicken. These results suggest conserved and non-conserved roles for ATX during neural development and organogenesis in these species.

Original languageEnglish
Pages (from-to)1134-1143
Number of pages10
JournalDevelopmental Dynamics
Volume236
Issue number4
DOIs
Publication statusPublished - Apr 2007
Externally publishedYes

Fingerprint

Chickens
Phospholipids
Rhombencephalon
Enzymes
nucleotide pyrophosphatase
Genes
Diencephalon
Neural Tube
Organogenesis
G-Protein-Coupled Receptors
Mesencephalon
Cerebellum
Embryonic Structures
Skin

Keywords

  • ATX
  • Autotaxin
  • Brain development
  • Chicken
  • Mouse
  • NPP2
  • Nucleotide pyrophosphatase-phosphodiesterase 2
  • Organogenesis

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Diversified expression patterns of autotaxin, a gene for phospholipid-generating enzyme during mouse and chicken development. / Ohuchi, Hideyo; Hayashibaral, Yasunori; Matsuda, Hironao; Onoi, Motoyoshi; Mitsumori, Masayuki; Tanaka, Masayuki; Aoki, Junken; Arai, Hiroyuki; Noji, Sumihare.

In: Developmental Dynamics, Vol. 236, No. 4, 04.2007, p. 1134-1143.

Research output: Contribution to journalArticle

Ohuchi, H, Hayashibaral, Y, Matsuda, H, Onoi, M, Mitsumori, M, Tanaka, M, Aoki, J, Arai, H & Noji, S 2007, 'Diversified expression patterns of autotaxin, a gene for phospholipid-generating enzyme during mouse and chicken development', Developmental Dynamics, vol. 236, no. 4, pp. 1134-1143. https://doi.org/10.1002/dvdy.21119
Ohuchi, Hideyo ; Hayashibaral, Yasunori ; Matsuda, Hironao ; Onoi, Motoyoshi ; Mitsumori, Masayuki ; Tanaka, Masayuki ; Aoki, Junken ; Arai, Hiroyuki ; Noji, Sumihare. / Diversified expression patterns of autotaxin, a gene for phospholipid-generating enzyme during mouse and chicken development. In: Developmental Dynamics. 2007 ; Vol. 236, No. 4. pp. 1134-1143.
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