Divergent and expeditious access to fused skeletons inspired by indole alkaloids and transtaganolides

Haruki Mizoguchi, Hiroki Oguri, Kiyoshi Tsuge, Hideaki Oikawa

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

We report the development of a divergent synthetic process entailing four-step access to the elaborate fused skeletons reminiscent of aspidophytines and transtaganolides. A variety of branched precursors were synthesized on the basis of Ugi condensations and installation of diazoimide and subjected to rhodium-catalyzed tandem reactions. Switching of cyclization modes was demonstrated by the choice of the amine building blocks installed at site C.

Original languageEnglish
Pages (from-to)3016-3019
Number of pages4
JournalOrganic Letters
Volume11
Issue number14
DOIs
Publication statusPublished - Jul 16 2009
Externally publishedYes

Fingerprint

Indole Alkaloids
Rhodium
alkaloids
Cyclization
indoles
rhodium
musculoskeletal system
Skeleton
installing
Amines
Condensation
amines
condensation
aspidophytine

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Divergent and expeditious access to fused skeletons inspired by indole alkaloids and transtaganolides. / Mizoguchi, Haruki; Oguri, Hiroki; Tsuge, Kiyoshi; Oikawa, Hideaki.

In: Organic Letters, Vol. 11, No. 14, 16.07.2009, p. 3016-3019.

Research output: Contribution to journalArticle

Mizoguchi, Haruki ; Oguri, Hiroki ; Tsuge, Kiyoshi ; Oikawa, Hideaki. / Divergent and expeditious access to fused skeletons inspired by indole alkaloids and transtaganolides. In: Organic Letters. 2009 ; Vol. 11, No. 14. pp. 3016-3019.
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