Divergent and expeditious access to fused skeletons inspired by indole alkaloids and transtaganolides

Haruki Mizoguchi, Hiroki Oguri, Kiyoshi Tsuge, Hideaki Oikawa

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

We report the development of a divergent synthetic process entailing four-step access to the elaborate fused skeletons reminiscent of aspidophytines and transtaganolides. A variety of branched precursors were synthesized on the basis of Ugi condensations and installation of diazoimide and subjected to rhodium-catalyzed tandem reactions. Switching of cyclization modes was demonstrated by the choice of the amine building blocks installed at site C.

Original languageEnglish
Pages (from-to)3016-3019
Number of pages4
JournalOrganic Letters
Volume11
Issue number14
DOIs
Publication statusPublished - Jul 16 2009
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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