TY - JOUR
T1 - Distribution of virulence-associated genes in Vibrio mimicus isolates from clinical and environmental origins
AU - Shinoda, Sumio
AU - Nakagawa, Tomoko
AU - Shi, Lei
AU - Bi, Kewei
AU - Kanoh, Yasuko
AU - Tomochika, Ken Ichi
AU - Miyoshi, Shin Ichi
AU - Shimada, Toshio
PY - 2004
Y1 - 2004
N2 - Distribution of virulence-associated genes in Vibrio mimicus was studied including the toxin genes ctxA, tdh, st and vmh and the genes necessary for regulation of toxin production, toxR, toxS, toxT, tcpA and tcpP. Approximately half of clinical V. mimicus isolates possessed one or more genes encoding V. cholerae enterotoxic factors such as ctxA, tdh and st. All of the clinical and environmental isolates possessed vmh encoding V. mimicus hemolysin (VMH). The ctxA encoding cholera toxin was detected in only 2 strains, 5% of the clinical isolates. Furthermore, there were very few strains possessing tcpP and toxT needed for the expression of ctxA. These results may suggest that VMH is a more important pathogenic factor than well recognized toxins such as cholera toxin (CT) in V. mimicus infection.
AB - Distribution of virulence-associated genes in Vibrio mimicus was studied including the toxin genes ctxA, tdh, st and vmh and the genes necessary for regulation of toxin production, toxR, toxS, toxT, tcpA and tcpP. Approximately half of clinical V. mimicus isolates possessed one or more genes encoding V. cholerae enterotoxic factors such as ctxA, tdh and st. All of the clinical and environmental isolates possessed vmh encoding V. mimicus hemolysin (VMH). The ctxA encoding cholera toxin was detected in only 2 strains, 5% of the clinical isolates. Furthermore, there were very few strains possessing tcpP and toxT needed for the expression of ctxA. These results may suggest that VMH is a more important pathogenic factor than well recognized toxins such as cholera toxin (CT) in V. mimicus infection.
KW - Enterotoxic factor
KW - Vibrio mimicus
KW - Virulence-associated genes
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U2 - 10.1111/j.1348-0421.2004.tb03551.x
DO - 10.1111/j.1348-0421.2004.tb03551.x
M3 - Article
C2 - 15272201
AN - SCOPUS:3242755208
VL - 48
SP - 547
EP - 551
JO - Microbiology and Immunology
JF - Microbiology and Immunology
SN - 0385-5600
IS - 7
ER -
