Distribution of virulence-associated genes in Vibrio mimicus isolates from clinical and environmental origins

Sumio Shinoda, Tomoko Nakagawa, Lei Shi, Kewei Bi, Yasuko Kanoh, Ken Ichi Tomochika, Shin Ichi Miyoshi, Toshio Shimada

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Distribution of virulence-associated genes in Vibrio mimicus was studied including the toxin genes ctxA, tdh, st and vmh and the genes necessary for regulation of toxin production, toxR, toxS, toxT, tcpA and tcpP. Approximately half of clinical V. mimicus isolates possessed one or more genes encoding V. cholerae enterotoxic factors such as ctxA, tdh and st. All of the clinical and environmental isolates possessed vmh encoding V. mimicus hemolysin (VMH). The ctxA encoding cholera toxin was detected in only 2 strains, 5% of the clinical isolates. Furthermore, there were very few strains possessing tcpP and toxT needed for the expression of ctxA. These results may suggest that VMH is a more important pathogenic factor than well recognized toxins such as cholera toxin (CT) in V. mimicus infection.

Original languageEnglish
Pages (from-to)547-551
Number of pages5
JournalMICROBIOLOGY and IMMUNOLOGY
Volume48
Issue number7
DOIs
Publication statusPublished - 2004

Keywords

  • Enterotoxic factor
  • Vibrio mimicus
  • Virulence-associated genes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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