Distribution of Streptococcus mutans strains with collagen-binding proteins in the oral cavity of IgA nephropathy patients

Taro Misaki, Shuhei Naka, Keiko Kuroda, Ryota Nomura, Tempei Shiooka, Yoshitaka Naito, Yumiko Suzuki, Hideo Yasuda, Taisuke Isozaki, Kazuhiko Nakano

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: IgA nephropathy (IgAN) is the most common primary chronic glomerulonephritis; however, its precise initiating pathogenesis remains unclear. Streptococcus mutans is a major pathogen of human dental caries. S. mutans strains with the cnm gene encoding Cnm, a collagen-binding protein, have been reported to contribute to the development of systemic diseases. However, the contribution of S. mutans with Cnm in the development of IgAN has not been reported. The aim of this study was to investigate the prevalence of cnm-positive S. mutans in IgAN patients and clarify the effects of cnm-positive S. mutans on the histological pathology of IgAN. Methods: We identified the cnm gene in S. mutans isolated in saliva specimens, which were collected from IgAN patients (n = 53) and control subjects (n = 50). We evaluated the collagen-binding properties of S. mutans in IgAN patients and controls. The clinical parameters and histological scores were also assessed in IgAN patients. Results: The rates of S. mutans isolation in IgAN and control groups were 84.0 and 84.9 %, respectively, not significantly dfferent. cnm-positive strains were significantly more prevalent in the IgAN group than in controls (32.1 vs. 14.0 %, p < 0.05). With regard to collagen-binding assays, the binding rates of cnm-positive strains were significantly higher in the IgAN group than in controls (96.6 vs. 30.0, p < 0.05). In addition, the segmental glomerulosclerosis scores were significantly higher in cnm-positive patients with IgAN than in cnm-negative patients with IgAN (0.94 vs. 0.57, p < 0.05). Conclusion: cnm-positive S. mutans strains are potentially associated with the pathogenesis of IgAN.

Original languageEnglish
Pages (from-to)844-850
Number of pages7
JournalClinical and Experimental Nephrology
Volume19
Issue number5
DOIs
Publication statusPublished - Oct 1 2015
Externally publishedYes

Fingerprint

Streptococcus mutans
Immunoglobulin A
Mouth
Carrier Proteins
Collagen
Control Groups
Dental Caries
Glomerulonephritis
Saliva
Genes

Keywords

  • cnm
  • Collagen-binding protein
  • IgA nephropathy
  • Streptococcus mutans

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)

Cite this

Distribution of Streptococcus mutans strains with collagen-binding proteins in the oral cavity of IgA nephropathy patients. / Misaki, Taro; Naka, Shuhei; Kuroda, Keiko; Nomura, Ryota; Shiooka, Tempei; Naito, Yoshitaka; Suzuki, Yumiko; Yasuda, Hideo; Isozaki, Taisuke; Nakano, Kazuhiko.

In: Clinical and Experimental Nephrology, Vol. 19, No. 5, 01.10.2015, p. 844-850.

Research output: Contribution to journalArticle

Misaki, T, Naka, S, Kuroda, K, Nomura, R, Shiooka, T, Naito, Y, Suzuki, Y, Yasuda, H, Isozaki, T & Nakano, K 2015, 'Distribution of Streptococcus mutans strains with collagen-binding proteins in the oral cavity of IgA nephropathy patients', Clinical and Experimental Nephrology, vol. 19, no. 5, pp. 844-850. https://doi.org/10.1007/s10157-014-1072-0
Misaki, Taro ; Naka, Shuhei ; Kuroda, Keiko ; Nomura, Ryota ; Shiooka, Tempei ; Naito, Yoshitaka ; Suzuki, Yumiko ; Yasuda, Hideo ; Isozaki, Taisuke ; Nakano, Kazuhiko. / Distribution of Streptococcus mutans strains with collagen-binding proteins in the oral cavity of IgA nephropathy patients. In: Clinical and Experimental Nephrology. 2015 ; Vol. 19, No. 5. pp. 844-850.
@article{ad7b34042d9344899f7850a3e0bbbc98,
title = "Distribution of Streptococcus mutans strains with collagen-binding proteins in the oral cavity of IgA nephropathy patients",
abstract = "Background: IgA nephropathy (IgAN) is the most common primary chronic glomerulonephritis; however, its precise initiating pathogenesis remains unclear. Streptococcus mutans is a major pathogen of human dental caries. S. mutans strains with the cnm gene encoding Cnm, a collagen-binding protein, have been reported to contribute to the development of systemic diseases. However, the contribution of S. mutans with Cnm in the development of IgAN has not been reported. The aim of this study was to investigate the prevalence of cnm-positive S. mutans in IgAN patients and clarify the effects of cnm-positive S. mutans on the histological pathology of IgAN. Methods: We identified the cnm gene in S. mutans isolated in saliva specimens, which were collected from IgAN patients (n = 53) and control subjects (n = 50). We evaluated the collagen-binding properties of S. mutans in IgAN patients and controls. The clinical parameters and histological scores were also assessed in IgAN patients. Results: The rates of S. mutans isolation in IgAN and control groups were 84.0 and 84.9 {\%}, respectively, not significantly dfferent. cnm-positive strains were significantly more prevalent in the IgAN group than in controls (32.1 vs. 14.0 {\%}, p < 0.05). With regard to collagen-binding assays, the binding rates of cnm-positive strains were significantly higher in the IgAN group than in controls (96.6 vs. 30.0, p < 0.05). In addition, the segmental glomerulosclerosis scores were significantly higher in cnm-positive patients with IgAN than in cnm-negative patients with IgAN (0.94 vs. 0.57, p < 0.05). Conclusion: cnm-positive S. mutans strains are potentially associated with the pathogenesis of IgAN.",
keywords = "cnm, Collagen-binding protein, IgA nephropathy, Streptococcus mutans",
author = "Taro Misaki and Shuhei Naka and Keiko Kuroda and Ryota Nomura and Tempei Shiooka and Yoshitaka Naito and Yumiko Suzuki and Hideo Yasuda and Taisuke Isozaki and Kazuhiko Nakano",
year = "2015",
month = "10",
day = "1",
doi = "10.1007/s10157-014-1072-0",
language = "English",
volume = "19",
pages = "844--850",
journal = "Clinical and Experimental Nephrology",
issn = "1342-1751",
publisher = "Springer Japan",
number = "5",

}

TY - JOUR

T1 - Distribution of Streptococcus mutans strains with collagen-binding proteins in the oral cavity of IgA nephropathy patients

AU - Misaki, Taro

AU - Naka, Shuhei

AU - Kuroda, Keiko

AU - Nomura, Ryota

AU - Shiooka, Tempei

AU - Naito, Yoshitaka

AU - Suzuki, Yumiko

AU - Yasuda, Hideo

AU - Isozaki, Taisuke

AU - Nakano, Kazuhiko

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Background: IgA nephropathy (IgAN) is the most common primary chronic glomerulonephritis; however, its precise initiating pathogenesis remains unclear. Streptococcus mutans is a major pathogen of human dental caries. S. mutans strains with the cnm gene encoding Cnm, a collagen-binding protein, have been reported to contribute to the development of systemic diseases. However, the contribution of S. mutans with Cnm in the development of IgAN has not been reported. The aim of this study was to investigate the prevalence of cnm-positive S. mutans in IgAN patients and clarify the effects of cnm-positive S. mutans on the histological pathology of IgAN. Methods: We identified the cnm gene in S. mutans isolated in saliva specimens, which were collected from IgAN patients (n = 53) and control subjects (n = 50). We evaluated the collagen-binding properties of S. mutans in IgAN patients and controls. The clinical parameters and histological scores were also assessed in IgAN patients. Results: The rates of S. mutans isolation in IgAN and control groups were 84.0 and 84.9 %, respectively, not significantly dfferent. cnm-positive strains were significantly more prevalent in the IgAN group than in controls (32.1 vs. 14.0 %, p < 0.05). With regard to collagen-binding assays, the binding rates of cnm-positive strains were significantly higher in the IgAN group than in controls (96.6 vs. 30.0, p < 0.05). In addition, the segmental glomerulosclerosis scores were significantly higher in cnm-positive patients with IgAN than in cnm-negative patients with IgAN (0.94 vs. 0.57, p < 0.05). Conclusion: cnm-positive S. mutans strains are potentially associated with the pathogenesis of IgAN.

AB - Background: IgA nephropathy (IgAN) is the most common primary chronic glomerulonephritis; however, its precise initiating pathogenesis remains unclear. Streptococcus mutans is a major pathogen of human dental caries. S. mutans strains with the cnm gene encoding Cnm, a collagen-binding protein, have been reported to contribute to the development of systemic diseases. However, the contribution of S. mutans with Cnm in the development of IgAN has not been reported. The aim of this study was to investigate the prevalence of cnm-positive S. mutans in IgAN patients and clarify the effects of cnm-positive S. mutans on the histological pathology of IgAN. Methods: We identified the cnm gene in S. mutans isolated in saliva specimens, which were collected from IgAN patients (n = 53) and control subjects (n = 50). We evaluated the collagen-binding properties of S. mutans in IgAN patients and controls. The clinical parameters and histological scores were also assessed in IgAN patients. Results: The rates of S. mutans isolation in IgAN and control groups were 84.0 and 84.9 %, respectively, not significantly dfferent. cnm-positive strains were significantly more prevalent in the IgAN group than in controls (32.1 vs. 14.0 %, p < 0.05). With regard to collagen-binding assays, the binding rates of cnm-positive strains were significantly higher in the IgAN group than in controls (96.6 vs. 30.0, p < 0.05). In addition, the segmental glomerulosclerosis scores were significantly higher in cnm-positive patients with IgAN than in cnm-negative patients with IgAN (0.94 vs. 0.57, p < 0.05). Conclusion: cnm-positive S. mutans strains are potentially associated with the pathogenesis of IgAN.

KW - cnm

KW - Collagen-binding protein

KW - IgA nephropathy

KW - Streptococcus mutans

UR - http://www.scopus.com/inward/record.url?scp=84944172264&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944172264&partnerID=8YFLogxK

U2 - 10.1007/s10157-014-1072-0

DO - 10.1007/s10157-014-1072-0

M3 - Article

C2 - 25492252

AN - SCOPUS:84944172264

VL - 19

SP - 844

EP - 850

JO - Clinical and Experimental Nephrology

JF - Clinical and Experimental Nephrology

SN - 1342-1751

IS - 5

ER -