Distribution of podoplanin-expressing cells in the mouse nervous systems

Miwa Tomooka, Chiaki Kaji, Hiroshi Kojima, Yoshihiko Sawa

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Podoplanin is a mucin-type glycoprotein which was first identified in podocytes. Recently, podoplanin has been successively reported as a marker for brain and peripheral nerve tumors, however, the distribution of podoplanin-expressing cells in normal nerves has not been fully investigated. This study aims to examine the podoplanin-expressing cell distribution in the mouse head and nervous systems. An immunohistochemical study showed that the podoplanin-positive areas in the mouse peripheral nerve and spinal cord are perineurial fibroblasts, satellite cells in the dorsal root ganglion, glia cells in the ventral and dorsal horns, and schwann cells in the ventral and dorsal roots; in the cranial meninges the dura mater, arachnoid, and pia mater; in the eye the optic nerve, retinal pigment epithelium, chorioidea, sclera, iris, lens epithelium, corneal epithelium, and conjunctival epithelium. In the mouse brain choroid plexus and ependyma were podoplanin-positive, and there were podoplanin-expressing brain parenchymal cells in the nuclei and cortex. The podoplanin-expressing cells were astrocyte marker GFAP-positive and there were no differences in the double positive cell distribution of several portions in the brain parenchyma except for the fornix. The results suggest that podoplanin may play a common role in nervous system support cells and eye constituents.

Original languageEnglish
Pages (from-to)171-177
Number of pages7
JournalActa Histochemica et Cytochemica
Volume46
Issue number6
DOIs
Publication statusPublished - 2013
Externally publishedYes

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Neurology
Nervous System
Brain
Spinal Nerve Roots
Retinal Pigments
Mucins
Fibroblasts
Peripheral Nervous System Neoplasms
Epithelium
Pia Mater
Tumors
Lenses
Optics
Glycoproteins
Ependyma
Anterior Horn Cells
Arachnoid
Posterior Horn Cells
Cells
Meninges

Keywords

  • Astrocyte
  • Glia cell
  • Nervous system
  • Podoplanin

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Physiology
  • Pathology and Forensic Medicine
  • Histology

Cite this

Distribution of podoplanin-expressing cells in the mouse nervous systems. / Tomooka, Miwa; Kaji, Chiaki; Kojima, Hiroshi; Sawa, Yoshihiko.

In: Acta Histochemica et Cytochemica, Vol. 46, No. 6, 2013, p. 171-177.

Research output: Contribution to journalArticle

Tomooka, Miwa ; Kaji, Chiaki ; Kojima, Hiroshi ; Sawa, Yoshihiko. / Distribution of podoplanin-expressing cells in the mouse nervous systems. In: Acta Histochemica et Cytochemica. 2013 ; Vol. 46, No. 6. pp. 171-177.
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