Distribution of oral mucosal bacteria with mecA in patients undergoing hematopoietic cell transplantation

Takayuki Ebinuma, Yoshihiko Soga, Takamaro Sato, Kazuyuki Matsunaga, Chieko Kudo, Hiroshi Maeda, Yoshinobu Maeda, Mitsune Tanimoto, Shogo Takashiba

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: We recently reported frequent detection of antibiotic-resistant bacteria on the oral mucosa during the period of hematopoietic cell transplantation (HCT) and suggested an association between oral mucositis and antibiotic-resistant bacterial infection. Methicillin-resistant Staphylococcus spp. were frequently detected, and the oral cavity may be a reservoir of the gene mediating methicillin resistance, mecA. Here, we examined the frequency of mecA carriers in patients undergoing HCT. Methods: Fifty-nine patients (male (M)=37, female (F)=22, 47.3±11.0 years) receiving HCT were enrolled in this study. Buccal swab samples were obtained four times from day -7 to day +20 (once/week), and mecA was detected by PCR. Fifty-two subjects without systemic disease, who completed dental treatment, especially periodontal treatment (M=21, F=31, 55.4±14.2 years), were also enrolled as controls and checked for mecA on the oral mucosa. Results: Seventy-six percent (45/59) of the HCT patients carried mecA at least once in the study period (days -7 to +20), while no control subjects had mecA. The frequency of mecA carriers was 19.2 % from days -7 to -1, while it was significantly increased on days +7 to +13 and +14 to +20, with frequencies of 60.9 and 63.2 %, respectively (P

Original languageEnglish
Pages (from-to)1679-1683
Number of pages5
JournalSupportive Care in Cancer
Volume22
Issue number6
DOIs
Publication statusPublished - 2014

Fingerprint

Cell Transplantation
Bacteria
Methicillin Resistance
Mouth Mucosa
Anti-Bacterial Agents
Stomatitis
Cheek
Staphylococcus
Bacterial Infections
Mouth
Tooth
Polymerase Chain Reaction
Therapeutics
Genes

Keywords

  • Antibiotic-resistant
  • Bacteria
  • Hematopoietic cell transplantation
  • mecA
  • Oral mucosa

ASJC Scopus subject areas

  • Oncology

Cite this

Distribution of oral mucosal bacteria with mecA in patients undergoing hematopoietic cell transplantation. / Ebinuma, Takayuki; Soga, Yoshihiko; Sato, Takamaro; Matsunaga, Kazuyuki; Kudo, Chieko; Maeda, Hiroshi; Maeda, Yoshinobu; Tanimoto, Mitsune; Takashiba, Shogo.

In: Supportive Care in Cancer, Vol. 22, No. 6, 2014, p. 1679-1683.

Research output: Contribution to journalArticle

Ebinuma, Takayuki ; Soga, Yoshihiko ; Sato, Takamaro ; Matsunaga, Kazuyuki ; Kudo, Chieko ; Maeda, Hiroshi ; Maeda, Yoshinobu ; Tanimoto, Mitsune ; Takashiba, Shogo. / Distribution of oral mucosal bacteria with mecA in patients undergoing hematopoietic cell transplantation. In: Supportive Care in Cancer. 2014 ; Vol. 22, No. 6. pp. 1679-1683.
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AU - Soga, Yoshihiko

AU - Sato, Takamaro

AU - Matsunaga, Kazuyuki

AU - Kudo, Chieko

AU - Maeda, Hiroshi

AU - Maeda, Yoshinobu

AU - Tanimoto, Mitsune

AU - Takashiba, Shogo

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AB - Purpose: We recently reported frequent detection of antibiotic-resistant bacteria on the oral mucosa during the period of hematopoietic cell transplantation (HCT) and suggested an association between oral mucositis and antibiotic-resistant bacterial infection. Methicillin-resistant Staphylococcus spp. were frequently detected, and the oral cavity may be a reservoir of the gene mediating methicillin resistance, mecA. Here, we examined the frequency of mecA carriers in patients undergoing HCT. Methods: Fifty-nine patients (male (M)=37, female (F)=22, 47.3±11.0 years) receiving HCT were enrolled in this study. Buccal swab samples were obtained four times from day -7 to day +20 (once/week), and mecA was detected by PCR. Fifty-two subjects without systemic disease, who completed dental treatment, especially periodontal treatment (M=21, F=31, 55.4±14.2 years), were also enrolled as controls and checked for mecA on the oral mucosa. Results: Seventy-six percent (45/59) of the HCT patients carried mecA at least once in the study period (days -7 to +20), while no control subjects had mecA. The frequency of mecA carriers was 19.2 % from days -7 to -1, while it was significantly increased on days +7 to +13 and +14 to +20, with frequencies of 60.9 and 63.2 %, respectively (P

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