Abstract
Purpose: We recently reported frequent detection of antibiotic-resistant bacteria on the oral mucosa during the period of hematopoietic cell transplantation (HCT) and suggested an association between oral mucositis and antibiotic-resistant bacterial infection. Methicillin-resistant Staphylococcus spp. were frequently detected, and the oral cavity may be a reservoir of the gene mediating methicillin resistance, mecA. Here, we examined the frequency of mecA carriers in patients undergoing HCT. Methods: Fifty-nine patients (male (M)=37, female (F)=22, 47.3±11.0 years) receiving HCT were enrolled in this study. Buccal swab samples were obtained four times from day -7 to day +20 (once/week), and mecA was detected by PCR. Fifty-two subjects without systemic disease, who completed dental treatment, especially periodontal treatment (M=21, F=31, 55.4±14.2 years), were also enrolled as controls and checked for mecA on the oral mucosa. Results: Seventy-six percent (45/59) of the HCT patients carried mecA at least once in the study period (days -7 to +20), while no control subjects had mecA. The frequency of mecA carriers was 19.2 % from days -7 to -1, while it was significantly increased on days +7 to +13 and +14 to +20, with frequencies of 60.9 and 63.2 %, respectively (P
| Original language | English |
|---|---|
| Pages (from-to) | 1679-1683 |
| Number of pages | 5 |
| Journal | Supportive Care in Cancer |
| Volume | 22 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- Antibiotic-resistant
- Bacteria
- Hematopoietic cell transplantation
- mecA
- Oral mucosa
ASJC Scopus subject areas
- Oncology
Cite this
Distribution of oral mucosal bacteria with mecA in patients undergoing hematopoietic cell transplantation. / Ebinuma, Takayuki; Soga, Yoshihiko; Sato, Takamaro; Matsunaga, Kazuyuki; Kudo, Chieko; Maeda, Hiroshi; Maeda, Yoshinobu; Tanimoto, Mitsune; Takashiba, Shogo.
In: Supportive Care in Cancer, Vol. 22, No. 6, 2014, p. 1679-1683.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Distribution of oral mucosal bacteria with mecA in patients undergoing hematopoietic cell transplantation
AU - Ebinuma, Takayuki
AU - Soga, Yoshihiko
AU - Sato, Takamaro
AU - Matsunaga, Kazuyuki
AU - Kudo, Chieko
AU - Maeda, Hiroshi
AU - Maeda, Yoshinobu
AU - Tanimoto, Mitsune
AU - Takashiba, Shogo
PY - 2014
Y1 - 2014
N2 - Purpose: We recently reported frequent detection of antibiotic-resistant bacteria on the oral mucosa during the period of hematopoietic cell transplantation (HCT) and suggested an association between oral mucositis and antibiotic-resistant bacterial infection. Methicillin-resistant Staphylococcus spp. were frequently detected, and the oral cavity may be a reservoir of the gene mediating methicillin resistance, mecA. Here, we examined the frequency of mecA carriers in patients undergoing HCT. Methods: Fifty-nine patients (male (M)=37, female (F)=22, 47.3±11.0 years) receiving HCT were enrolled in this study. Buccal swab samples were obtained four times from day -7 to day +20 (once/week), and mecA was detected by PCR. Fifty-two subjects without systemic disease, who completed dental treatment, especially periodontal treatment (M=21, F=31, 55.4±14.2 years), were also enrolled as controls and checked for mecA on the oral mucosa. Results: Seventy-six percent (45/59) of the HCT patients carried mecA at least once in the study period (days -7 to +20), while no control subjects had mecA. The frequency of mecA carriers was 19.2 % from days -7 to -1, while it was significantly increased on days +7 to +13 and +14 to +20, with frequencies of 60.9 and 63.2 %, respectively (P
AB - Purpose: We recently reported frequent detection of antibiotic-resistant bacteria on the oral mucosa during the period of hematopoietic cell transplantation (HCT) and suggested an association between oral mucositis and antibiotic-resistant bacterial infection. Methicillin-resistant Staphylococcus spp. were frequently detected, and the oral cavity may be a reservoir of the gene mediating methicillin resistance, mecA. Here, we examined the frequency of mecA carriers in patients undergoing HCT. Methods: Fifty-nine patients (male (M)=37, female (F)=22, 47.3±11.0 years) receiving HCT were enrolled in this study. Buccal swab samples were obtained four times from day -7 to day +20 (once/week), and mecA was detected by PCR. Fifty-two subjects without systemic disease, who completed dental treatment, especially periodontal treatment (M=21, F=31, 55.4±14.2 years), were also enrolled as controls and checked for mecA on the oral mucosa. Results: Seventy-six percent (45/59) of the HCT patients carried mecA at least once in the study period (days -7 to +20), while no control subjects had mecA. The frequency of mecA carriers was 19.2 % from days -7 to -1, while it was significantly increased on days +7 to +13 and +14 to +20, with frequencies of 60.9 and 63.2 %, respectively (P
KW - Antibiotic-resistant
KW - Bacteria
KW - Hematopoietic cell transplantation
KW - mecA
KW - Oral mucosa
UR - http://www.scopus.com/inward/record.url?scp=84902344906&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84902344906&partnerID=8YFLogxK
U2 - 10.1007/s00520-014-2151-1
DO - 10.1007/s00520-014-2151-1
M3 - Article
C2 - 24535241
AN - SCOPUS:84902344906
VL - 22
SP - 1679
EP - 1683
JO - Supportive Care in Cancer
JF - Supportive Care in Cancer
SN - 0941-4355
IS - 6
ER -