Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains

Kazuhiro Imamura, Nozomi Hishikawa, Makoto Sawada, Toshiharu Nagatsu, Mari Yoshida, Yoshio Hashizume

Research output: Contribution to journalArticle

341 Citations (Scopus)

Abstract

There are numerous observations confirming that microglia expressing major histocompatibility complex (MHC) class II molecules are associated with the central nervous system (CNS) in aging and pathological conditions. In this study, we investigated the distribution of MHC class II-positive microglia in Parkinson's disease (PD) brains. The number of MHC class II-positive microglia in the substantia nigra (SN) and putamen increased as the neuronal degeneration of the SN proceeded. These cells were also ICAM-1 (CD54) and LFA-1 (CD11a) positive. The number of activated microglia not only in the SN and putamen but also in the hippocampus, transentorhinal cortex, cingulate cortex and temporal cortex in PD was significantly higher than that in the normal control. Most activated microglia persisted regardless of the presence or absence of Lewy bodies. They were frequently associated not only with α-synuclein-positive Lewy neurites, but also with TH-16-positive dopaminergic and WH-3-positive serotonergic neurites, as well as MAP-2- and SMI-32-positive neurites. These activated microglia were also positive for TNF-α and interleukin-6, which are known to have a neuroprotective function. We conclude that MHC class II-positive microglia are a sensitive index of neuropathological change and are actively associated with damaged neurons and neurites.

Original languageEnglish
Pages (from-to)518-526
Number of pages9
JournalActa Neuropathologica
Volume106
Issue number6
DOIs
Publication statusPublished - Dec 2003
Externally publishedYes

Fingerprint

Microglia
Major Histocompatibility Complex
Parkinson Disease
Cytokines
Neurites
Brain
Substantia Nigra
Putamen
Synucleins
Lewy Bodies
Lymphocyte Function-Associated Antigen-1
Gyrus Cinguli
Temporal Lobe
Intercellular Adhesion Molecule-1
Interleukin-6
Hippocampus
Central Nervous System
Neurons

Keywords

  • Cytokines
  • ICAM-1
  • MHC class II antigen
  • Microglia
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains. / Imamura, Kazuhiro; Hishikawa, Nozomi; Sawada, Makoto; Nagatsu, Toshiharu; Yoshida, Mari; Hashizume, Yoshio.

In: Acta Neuropathologica, Vol. 106, No. 6, 12.2003, p. 518-526.

Research output: Contribution to journalArticle

Imamura, Kazuhiro ; Hishikawa, Nozomi ; Sawada, Makoto ; Nagatsu, Toshiharu ; Yoshida, Mari ; Hashizume, Yoshio. / Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains. In: Acta Neuropathologica. 2003 ; Vol. 106, No. 6. pp. 518-526.
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