Distribution of adrenomedullin-containing perivascular nerves in the rat mesenteric artery

N. Hobara, A. Nakamura, A. Ohtsuka, M. Narasaki, K. Shibata, Y. Gomoita, H. Kawasaki

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Distribution of adrenomedullin (AM)-containing perivascular nerve fibers was studied in rat mesenteric arteries. Many fibers containing AM-like immunoreactivity (LI) were observed in the adventitia. AM-LI fibers were abolished by cold storage denervation or capsaicin but not 6-hydroxydopamine. Double immunostainings showed colocalization of AM-LI with calcitonin gene-related peptide (CGRP)-LI. The dorsal root ganglia had many AM-positive cells and AM mRNA detected by RT-PCR. Electron microscopy study revealed high proportions of immunogold labeling for AM and colocalization of both AM-LI and CGRP-LI in unmyelinated nerve axons. These results suggest that AM-containing perivascular nerves are distributed in the rat mesenteric artery.

Original languageEnglish
Pages (from-to)589-599
Number of pages11
Issue number4
Publication statusPublished - Apr 1 2004



  • Adrenomedullin
  • Calcitonin gene-related peptide
  • Capsaicin-sensitive nerve
  • Neuropeptide Y
  • Perivascular nerve
  • Rat mesenteric artery

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

Cite this

Hobara, N., Nakamura, A., Ohtsuka, A., Narasaki, M., Shibata, K., Gomoita, Y., & Kawasaki, H. (2004). Distribution of adrenomedullin-containing perivascular nerves in the rat mesenteric artery. Peptides, 25(4), 589-599. https://doi.org/10.1016/j.peptides.2004.02.005