Abstract
Distribution of adrenomedullin (AM)-containing perivascular nerve fibers was studied in rat mesenteric arteries. Many fibers containing AM-like immunoreactivity (LI) were observed in the adventitia. AM-LI fibers were abolished by cold storage denervation or capsaicin but not 6-hydroxydopamine. Double immunostainings showed colocalization of AM-LI with calcitonin gene-related peptide (CGRP)-LI. The dorsal root ganglia had many AM-positive cells and AM mRNA detected by RT-PCR. Electron microscopy study revealed high proportions of immunogold labeling for AM and colocalization of both AM-LI and CGRP-LI in unmyelinated nerve axons. These results suggest that AM-containing perivascular nerves are distributed in the rat mesenteric artery.
Original language | English |
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Pages (from-to) | 589-599 |
Number of pages | 11 |
Journal | Peptides |
Volume | 25 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr 2004 |
Keywords
- Adrenomedullin
- Calcitonin gene-related peptide
- Capsaicin-sensitive nerve
- Neuropeptide Y
- Perivascular nerve
- Rat mesenteric artery
ASJC Scopus subject areas
- Biochemistry
- Physiology
- Endocrinology
- Cellular and Molecular Neuroscience