Abstract
Distribution of adrenomedullin (AM)-containing perivascular nerve fibers was studied in rat mesenteric arteries. Many fibers containing AM-like immunoreactivity (LI) were observed in the adventitia. AM-LI fibers were abolished by cold storage denervation or capsaicin but not 6-hydroxydopamine. Double immunostainings showed colocalization of AM-LI with calcitonin gene-related peptide (CGRP)-LI. The dorsal root ganglia had many AM-positive cells and AM mRNA detected by RT-PCR. Electron microscopy study revealed high proportions of immunogold labeling for AM and colocalization of both AM-LI and CGRP-LI in unmyelinated nerve axons. These results suggest that AM-containing perivascular nerves are distributed in the rat mesenteric artery.
| Original language | English |
|---|---|
| Pages (from-to) | 589-599 |
| Number of pages | 11 |
| Journal | Peptides |
| Volume | 25 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2004 |
Keywords
- Adrenomedullin
- Calcitonin gene-related peptide
- Capsaicin-sensitive nerve
- Neuropeptide Y
- Perivascular nerve
- Rat mesenteric artery
ASJC Scopus subject areas
- Biochemistry
- Physiology
- Endocrinology
- Cellular and Molecular Neuroscience
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Cite this
Hobara, N., Nakamura, A., Ohtsuka, A., Narasaki, M., Shibata, K., Gomoita, Y., & Kawasaki, H. (2004). Distribution of adrenomedullin-containing perivascular nerves in the rat mesenteric artery. Peptides, 25(4), 589-599. https://doi.org/10.1016/j.peptides.2004.02.005