Distinct neural mechanisms for the control of thirst and salt appetite in the subfornical organ

Takashi Matsuda, Takeshi Y. Hiyama, Fumio Niimura, Taiji Matsusaka, Akiyoshi Fukamizu, Kenta Kobayashi, Kazuto Kobayashi, Masaharu Noda

Research output: Contribution to journalArticlepeer-review

74 Citations (Scopus)

Abstract

Body fluid conditions are continuously monitored in the brain to regulate thirst and salt-appetite sensations. Angiotensin II drives both thirst and salt appetite; however, the neural mechanisms underlying selective water- and/or salt-intake behaviors remain unknown. Using optogenetics, we show that thirst and salt appetite are driven by distinct groups of angiotensin II receptor type 1a-positive excitatory neurons in the subfornical organ. Neurons projecting to the organum vasculosum lamina terminalis control water intake, while those projecting to the ventral part of the bed nucleus of the stria terminalis control salt intake. Thirst-driving neurons are suppressed under sodium-depleted conditions through cholecystokinin-mediated activation of GABAergic neurons. In contrast, the salt appetite-driving neurons were suppressed under dehydrated conditions through activation of another population of GABAergic neurons by Na x signals. These distinct mechanisms in the subfornical organ may underlie the selective intakes of water and/or salt and may contribute to body fluid homeostasis.

Original languageEnglish
Pages (from-to)230-241
Number of pages12
JournalNature Neuroscience
Volume20
Issue number2
DOIs
Publication statusPublished - Feb 1 2017
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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