TY - JOUR
T1 - Distinct morphologic, phenotypic, and clinical-course characteristics of indolent peripheral T-cell lymphoma
AU - Hayashi, Eiko
AU - Takata, Katsuyoshi
AU - Sato, Yasuharu
AU - Tashiro, Yukie
AU - Tachiyama, Yoshiro
AU - Sawada-Kitamura, Seiko
AU - Hiramatsu, Yasushi
AU - Sugiguchi, Shun
AU - Nose, Soichiro
AU - Hirokawa, Mitsuyoshi
AU - Ando, Midori
AU - Alkader, Lamia Abd
AU - Maeda, Yoshinobu
AU - Tanimoto, Mitsune
AU - Yoshino, Tadashi
N1 - Funding Information:
Funding: This work was supported, in part, by a Grant-in-Aid for Cancer Research (21-6-3) from the Ministry of Health, Labour and Welfare, Tokyo, Japan .
PY - 2013/9
Y1 - 2013/9
N2 - Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) consists of a heterogeneous group of lymphomas. Patients generally show an aggressive clinical course and very poor outcome. Although the 2008 World Health Organization classification of PTCL-NOS includes 3 variants, low-grade lymphoma is not included. Of 277 PTCL-NOS cases recorded in our consultation files, we examined the clinicopathologic characteristics of 10 patients with T-cell lymphomas composed of small-sized cells with slight nuclear atypia. Eight patients showed extranodal involvement (5 patients, spleen; 3 patients, thyroid), and 5 patients were at clinical stage I or II. Histologically, all samples presented diffuse infiltrate of small lymphoid cells, with few mitotic figures. Immunohistologically, all samples were positive for CD3, and CD20 was detected in 5 samples. All samples showed a low Ki-67 labeling index (mean, 1.05%), and 7 samples were positive for central memory T-cell markers. Clonal T-cell receptor γ chain and/or α-β chain gene rearrangements were detected in all 10 patients. Five patients received chemotherapy, whereas for 3 patients, treatment consisted only of observation following surgical resection of the spleen or thyroid. Nine patients were alive at a median follow-up time of 19.5 months, whereas 1 patient died of an unrelated disease. The present study strongly indicates that T-cell lymphoma with small-sized lymphoma cells and a low Ki-67 labeling index is a distinct variant. Recognition of this novel lymphoma subtype, which should not be defined merely as PTCL-NOS, should be seriously considered.
AB - Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) consists of a heterogeneous group of lymphomas. Patients generally show an aggressive clinical course and very poor outcome. Although the 2008 World Health Organization classification of PTCL-NOS includes 3 variants, low-grade lymphoma is not included. Of 277 PTCL-NOS cases recorded in our consultation files, we examined the clinicopathologic characteristics of 10 patients with T-cell lymphomas composed of small-sized cells with slight nuclear atypia. Eight patients showed extranodal involvement (5 patients, spleen; 3 patients, thyroid), and 5 patients were at clinical stage I or II. Histologically, all samples presented diffuse infiltrate of small lymphoid cells, with few mitotic figures. Immunohistologically, all samples were positive for CD3, and CD20 was detected in 5 samples. All samples showed a low Ki-67 labeling index (mean, 1.05%), and 7 samples were positive for central memory T-cell markers. Clonal T-cell receptor γ chain and/or α-β chain gene rearrangements were detected in all 10 patients. Five patients received chemotherapy, whereas for 3 patients, treatment consisted only of observation following surgical resection of the spleen or thyroid. Nine patients were alive at a median follow-up time of 19.5 months, whereas 1 patient died of an unrelated disease. The present study strongly indicates that T-cell lymphoma with small-sized lymphoma cells and a low Ki-67 labeling index is a distinct variant. Recognition of this novel lymphoma subtype, which should not be defined merely as PTCL-NOS, should be seriously considered.
KW - CD20
KW - Good prognosis
KW - Indolent PTCL
KW - Ki-67
KW - Memory T cell
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U2 - 10.1016/j.humpath.2013.03.002
DO - 10.1016/j.humpath.2013.03.002
M3 - Article
C2 - 23706909
AN - SCOPUS:84883455500
VL - 44
SP - 1927
EP - 1936
JO - Human Pathology
JF - Human Pathology
SN - 0046-8177
IS - 9
ER -