Distinct developmental expression of two isoforms of Ca2+/calmodulin-dependent protein kinase kinases and their involvement in hippocampal dendritic formation

Akifumi Kamata, Hiroyuki Sakagami, Hiroshi Tokumitsu, Masashi Sanda, Yuji Owada, Kohji Fukunaga, Hisatake Kondo

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Ca2+/calmodulin-dependent protein kinase kinases (CaMKKs) are upstream protein kinases that phosphorylate and activate CaMKI and CaMKIV, both of which are involved in a variety of neuronal functions. Here, we first demonstrated that the two isoforms of CaMKK were differentially expressed during neural development by in situ hybridization. We also demonstrated that both dominant negative and pharmacological interference with CaMKK inhibitor, STO-609 resulted in a significant decrease in the number of primary dendrites of cultured hippocampal neurons. Our present findings provide the detailed anatomical information on the developmental expression of CaMKKs and the functional involvement of CaMKK in the formation of primary dendrites.

Original languageEnglish
Pages (from-to)143-148
Number of pages6
JournalNeuroscience Letters
Volume423
Issue number2
DOIs
Publication statusPublished - Aug 16 2007
Externally publishedYes

Keywords

  • Calcium
  • Calmodulin
  • Dendrite
  • Hippocampus
  • Kinase
  • Plasticity

ASJC Scopus subject areas

  • Neuroscience(all)

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