Distinct cellular compartment of cyclin-dependent kinase 5 (Cdk5) and neuron-specific Cdk5 activator protein (p35(nck5a)) in the developing rat cerebellum

Masayuki Matsushita, Kazuhito Tomizawa, Lu Yun-Fei, Akiyoshi Moriwaki, Masaaki Tokuda, Toshifumi Itano, Jerry H. Wang, Osamu Hatase, Hideki Matsui

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We have elucidated the spatial and temporal localization of Cdk5 and p35(nck5a) in the developing rat postnatal cerebellum. Both proteins were highly expressed in cell bodies of post mitotic and immature neurons. The localization of Cdk5 in cellular compartment was changed from cell body to the axon in development. On the other hand, p35(nck5a) was always expressed in the cell body throughout cerebellum development. The Cdk5 kinase activity was correlated with the expression of p35(nck5a) rather than that of Cdk5. These results indicate that p35(nck5a) is a physiological activator of Cdk5 in immature neurons and further suggest that Cdk5 has another function in mature neurons.

Original languageEnglish
Pages (from-to)319-322
Number of pages4
JournalBrain Research
Volume734
Issue number1-2
DOIs
Publication statusPublished - Sep 23 1996

Keywords

  • Cell cycle
  • Cyclin
  • Cyclin-dependent kinase
  • Development
  • Plasticity
  • Tan protein

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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    Matsushita, M., Tomizawa, K., Yun-Fei, L., Moriwaki, A., Tokuda, M., Itano, T., Wang, J. H., Hatase, O., & Matsui, H. (1996). Distinct cellular compartment of cyclin-dependent kinase 5 (Cdk5) and neuron-specific Cdk5 activator protein (p35(nck5a)) in the developing rat cerebellum. Brain Research, 734(1-2), 319-322. https://doi.org/10.1016/0006-8993(96)00702-0