Dissociative increase of oligodendrocyte progenitor cells between young and aged rats after transient cerebral ischemia

Kentaro Ohta; Masanori Iwai; Keiko Sato; Nobuhiko Omori; Isao Nagano; Mikio Shoji; Koji Abe

doi:10.1016/S0304-3940(02)01177-1

Dissociative increase of oligodendrocyte progenitor cells between young and aged rats after transient cerebral ischemia

Kentaro Ohta, Masanori Iwai, Keiko Sato, Nobuhiko Omori, Isao Nagano, Mikio Shoji, Koji Abe

Research output: Contribution to journal › Article › peer-review

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Abstract

To investigate the effect of aging on the oligodendrocyte progenitor cells (OPCs) after cerebral ischemia, neuron-glia antigen 2 (NG2) chondroitin sulfate proteoglycan was examined at 1, 3 and 7 days after 90 min of transient middle cerebral artery occlusion in young and aged brains. The number of NG2 positive cells increased in the ischemic penumbra at 3 and 7 days after reperfusion, while those decreased in the ischemic core. At 7 days, the number of NG2 positive cells was significantly greater in the young than the aged brains, and the processes of NG2 positive cells enlarged and were highly branched in the young than the aged brains. These results suggest that the young brain showed a higher potential of proliferation and process branching of OPCs than the aged brains.

Original language	English
Pages (from-to)	159-162
Number of pages	4
Journal	Neuroscience Letters
Volume	335
Issue number	3
DOIs	https://doi.org/10.1016/S0304-3940(02)01177-1
Publication status	Published - Jan 2 2003

Keywords

Aging
Brain infarction
Neuron-glial antigen 2 (NG2)
Oligodendrocyte progenitor cell
Remyelination
Transient ischemia

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0304-3940(02)01177-1

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title = "Dissociative increase of oligodendrocyte progenitor cells between young and aged rats after transient cerebral ischemia",

abstract = "To investigate the effect of aging on the oligodendrocyte progenitor cells (OPCs) after cerebral ischemia, neuron-glia antigen 2 (NG2) chondroitin sulfate proteoglycan was examined at 1, 3 and 7 days after 90 min of transient middle cerebral artery occlusion in young and aged brains. The number of NG2 positive cells increased in the ischemic penumbra at 3 and 7 days after reperfusion, while those decreased in the ischemic core. At 7 days, the number of NG2 positive cells was significantly greater in the young than the aged brains, and the processes of NG2 positive cells enlarged and were highly branched in the young than the aged brains. These results suggest that the young brain showed a higher potential of proliferation and process branching of OPCs than the aged brains.",

keywords = "Aging, Brain infarction, Neuron-glial antigen 2 (NG2), Oligodendrocyte progenitor cell, Remyelination, Transient ischemia",

author = "Kentaro Ohta and Masanori Iwai and Keiko Sato and Nobuhiko Omori and Isao Nagano and Mikio Shoji and Koji Abe",

note = "Funding Information: This work was partly supported Grant-in-Aid for Scientific Research (B) 12470141 from the Ministry of Education, Science, Culture and Sports of Japan, and by grants (K. Tashiro, Y. Itoyama) and Comprehensive Research on Aging and Health (H11-Choju-010, No. 207, Koizumi A) from the Ministry of Health and Welfare of Japan.",

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doi = "10.1016/S0304-3940(02)01177-1",

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T1 - Dissociative increase of oligodendrocyte progenitor cells between young and aged rats after transient cerebral ischemia

AU - Ohta, Kentaro

AU - Iwai, Masanori

AU - Sato, Keiko

AU - Omori, Nobuhiko

AU - Nagano, Isao

AU - Shoji, Mikio

AU - Abe, Koji

N1 - Funding Information: This work was partly supported Grant-in-Aid for Scientific Research (B) 12470141 from the Ministry of Education, Science, Culture and Sports of Japan, and by grants (K. Tashiro, Y. Itoyama) and Comprehensive Research on Aging and Health (H11-Choju-010, No. 207, Koizumi A) from the Ministry of Health and Welfare of Japan.

PY - 2003/1/2

Y1 - 2003/1/2

N2 - To investigate the effect of aging on the oligodendrocyte progenitor cells (OPCs) after cerebral ischemia, neuron-glia antigen 2 (NG2) chondroitin sulfate proteoglycan was examined at 1, 3 and 7 days after 90 min of transient middle cerebral artery occlusion in young and aged brains. The number of NG2 positive cells increased in the ischemic penumbra at 3 and 7 days after reperfusion, while those decreased in the ischemic core. At 7 days, the number of NG2 positive cells was significantly greater in the young than the aged brains, and the processes of NG2 positive cells enlarged and were highly branched in the young than the aged brains. These results suggest that the young brain showed a higher potential of proliferation and process branching of OPCs than the aged brains.

AB - To investigate the effect of aging on the oligodendrocyte progenitor cells (OPCs) after cerebral ischemia, neuron-glia antigen 2 (NG2) chondroitin sulfate proteoglycan was examined at 1, 3 and 7 days after 90 min of transient middle cerebral artery occlusion in young and aged brains. The number of NG2 positive cells increased in the ischemic penumbra at 3 and 7 days after reperfusion, while those decreased in the ischemic core. At 7 days, the number of NG2 positive cells was significantly greater in the young than the aged brains, and the processes of NG2 positive cells enlarged and were highly branched in the young than the aged brains. These results suggest that the young brain showed a higher potential of proliferation and process branching of OPCs than the aged brains.

KW - Aging

KW - Brain infarction

KW - Neuron-glial antigen 2 (NG2)

KW - Oligodendrocyte progenitor cell

KW - Remyelination

KW - Transient ischemia

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Dissociative increase of oligodendrocyte progenitor cells between young and aged rats after transient cerebral ischemia

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