Dissociative increase of oligodendrocyte progenitor cells between young and aged rats after transient cerebral ischemia.

K. Ohta, M. Iwai, K. Sato, N. Omori, I. Nagano, M. Shoji, K. Abe

Research output: Contribution to journalArticle

Abstract

Oligodendrocyte progenitor cells (OPCs) mature to oligodendrocyte and remyelinate axons. OPCs express neuron-glial antigen 2 (NG2) chondroitin sulfate proteoglycan. We stained NG2 to investigate the effect of aging on the OPCs after cerebral ischemia. NG2 positive cells were examined at 1, 3, 7 days after 90 min of transient middle cerebral artery occlusion in young and aged brains. The number of NG2 positive cells increased in the ischemic penumbra at 3 and 7 days after reperfusion. At 7 day, the number of NG2 positive cells was significantly greater in the young than the aged brains, and the processes of NG2 positive cells enlarged and were more highly branched in the young than the aged brains. These results suggest that the young brain shows a higher potential of proliferation and process branching of OPCs than the aged brain.

Original languageEnglish
Pages (from-to)187-189
Number of pages3
JournalActa Neurochirurgica, Supplementum
Volume86
Publication statusPublished - 2003

Fingerprint

Transient Ischemic Attack
Oligodendroglia
Neuroglia
Stem Cells
Neurons
Antigens
Brain
Chondroitin Sulfate Proteoglycans
Middle Cerebral Artery Infarction
Brain Ischemia
Reperfusion
Axons

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Neurology

Cite this

Dissociative increase of oligodendrocyte progenitor cells between young and aged rats after transient cerebral ischemia. / Ohta, K.; Iwai, M.; Sato, K.; Omori, N.; Nagano, I.; Shoji, M.; Abe, K.

In: Acta Neurochirurgica, Supplementum, Vol. 86, 2003, p. 187-189.

Research output: Contribution to journalArticle

@article{ad3a328b73d2481ba100572ed0fd8364,
title = "Dissociative increase of oligodendrocyte progenitor cells between young and aged rats after transient cerebral ischemia.",
abstract = "Oligodendrocyte progenitor cells (OPCs) mature to oligodendrocyte and remyelinate axons. OPCs express neuron-glial antigen 2 (NG2) chondroitin sulfate proteoglycan. We stained NG2 to investigate the effect of aging on the OPCs after cerebral ischemia. NG2 positive cells were examined at 1, 3, 7 days after 90 min of transient middle cerebral artery occlusion in young and aged brains. The number of NG2 positive cells increased in the ischemic penumbra at 3 and 7 days after reperfusion. At 7 day, the number of NG2 positive cells was significantly greater in the young than the aged brains, and the processes of NG2 positive cells enlarged and were more highly branched in the young than the aged brains. These results suggest that the young brain shows a higher potential of proliferation and process branching of OPCs than the aged brain.",
author = "K. Ohta and M. Iwai and K. Sato and N. Omori and I. Nagano and M. Shoji and K. Abe",
year = "2003",
language = "English",
volume = "86",
pages = "187--189",
journal = "Acta Neurochirurgica, Supplement",
issn = "0065-1419",
publisher = "Springer Wien",

}

TY - JOUR

T1 - Dissociative increase of oligodendrocyte progenitor cells between young and aged rats after transient cerebral ischemia.

AU - Ohta, K.

AU - Iwai, M.

AU - Sato, K.

AU - Omori, N.

AU - Nagano, I.

AU - Shoji, M.

AU - Abe, K.

PY - 2003

Y1 - 2003

N2 - Oligodendrocyte progenitor cells (OPCs) mature to oligodendrocyte and remyelinate axons. OPCs express neuron-glial antigen 2 (NG2) chondroitin sulfate proteoglycan. We stained NG2 to investigate the effect of aging on the OPCs after cerebral ischemia. NG2 positive cells were examined at 1, 3, 7 days after 90 min of transient middle cerebral artery occlusion in young and aged brains. The number of NG2 positive cells increased in the ischemic penumbra at 3 and 7 days after reperfusion. At 7 day, the number of NG2 positive cells was significantly greater in the young than the aged brains, and the processes of NG2 positive cells enlarged and were more highly branched in the young than the aged brains. These results suggest that the young brain shows a higher potential of proliferation and process branching of OPCs than the aged brain.

AB - Oligodendrocyte progenitor cells (OPCs) mature to oligodendrocyte and remyelinate axons. OPCs express neuron-glial antigen 2 (NG2) chondroitin sulfate proteoglycan. We stained NG2 to investigate the effect of aging on the OPCs after cerebral ischemia. NG2 positive cells were examined at 1, 3, 7 days after 90 min of transient middle cerebral artery occlusion in young and aged brains. The number of NG2 positive cells increased in the ischemic penumbra at 3 and 7 days after reperfusion. At 7 day, the number of NG2 positive cells was significantly greater in the young than the aged brains, and the processes of NG2 positive cells enlarged and were more highly branched in the young than the aged brains. These results suggest that the young brain shows a higher potential of proliferation and process branching of OPCs than the aged brain.

UR - http://www.scopus.com/inward/record.url?scp=1442352760&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1442352760&partnerID=8YFLogxK

M3 - Article

VL - 86

SP - 187

EP - 189

JO - Acta Neurochirurgica, Supplement

JF - Acta Neurochirurgica, Supplement

SN - 0065-1419

ER -