Dissociation of HSP70 and HSC70 heat shock mRNA inductions as an early biochemical marker of ischemic neuronal death

Koji Abe; Jun ichi Kawagoe; Masashi Aoki; Kyuya Kogure

doi:10.1016/0304-3940(93)90762-A

Dissociation of HSP70 and HSC70 heat shock mRNA inductions as an early biochemical marker of ischemic neuronal death

Koji Abe, Jun ichi Kawagoe, Masashi Aoki, Kyuya Kogure

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

A significant dissociation of HSP70 and HSC70 heat shock mRNAs after a 10-min transient forebrain ischemia in gerbil was found only in the hippocampal CA1 neurons which eventually die after the initial ischemic insult, while other hippocampal neurons such as the dentate granule and the CA3 cells which survive ischemia expressed both mRNAs cooperatively. The dissociation was observed as early as after 8 h of reperfusion, a period far shorter than 3-4 days, when the cell death becomes pathologically evident. Thus, the dissociation may serve as a set of early biochemical markers for ischemic neuronal cell death.

Original language	English
Pages (from-to)	165-168
Number of pages	4
Journal	Neuroscience Letters
Volume	149
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(93)90762-A
Publication status	Published - Jan 12 1993
Externally published	Yes

Keywords

Heat shock cognate protein
Heat shock protein
Ischemia

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(93)90762-A

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title = "Dissociation of HSP70 and HSC70 heat shock mRNA inductions as an early biochemical marker of ischemic neuronal death",

abstract = "A significant dissociation of HSP70 and HSC70 heat shock mRNAs after a 10-min transient forebrain ischemia in gerbil was found only in the hippocampal CA1 neurons which eventually die after the initial ischemic insult, while other hippocampal neurons such as the dentate granule and the CA3 cells which survive ischemia expressed both mRNAs cooperatively. The dissociation was observed as early as after 8 h of reperfusion, a period far shorter than 3-4 days, when the cell death becomes pathologically evident. Thus, the dissociation may serve as a set of early biochemical markers for ischemic neuronal cell death.",

keywords = "Heat shock cognate protein, Heat shock protein, Ischemia",

author = "Koji Abe and Kawagoe, {Jun ichi} and Masashi Aoki and Kyuya Kogure",

note = "Funding Information: This work was partly supported by Monbusho Grants 01044018 and 03404028, a grant of the Ministry of Welfare and Health of Japan, and the Sasakawa Medical Foundation,",

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T1 - Dissociation of HSP70 and HSC70 heat shock mRNA inductions as an early biochemical marker of ischemic neuronal death

AU - Abe, Koji

AU - Kawagoe, Jun ichi

AU - Aoki, Masashi

AU - Kogure, Kyuya

N1 - Funding Information: This work was partly supported by Monbusho Grants 01044018 and 03404028, a grant of the Ministry of Welfare and Health of Japan, and the Sasakawa Medical Foundation,

PY - 1993/1/12

Y1 - 1993/1/12

N2 - A significant dissociation of HSP70 and HSC70 heat shock mRNAs after a 10-min transient forebrain ischemia in gerbil was found only in the hippocampal CA1 neurons which eventually die after the initial ischemic insult, while other hippocampal neurons such as the dentate granule and the CA3 cells which survive ischemia expressed both mRNAs cooperatively. The dissociation was observed as early as after 8 h of reperfusion, a period far shorter than 3-4 days, when the cell death becomes pathologically evident. Thus, the dissociation may serve as a set of early biochemical markers for ischemic neuronal cell death.

AB - A significant dissociation of HSP70 and HSC70 heat shock mRNAs after a 10-min transient forebrain ischemia in gerbil was found only in the hippocampal CA1 neurons which eventually die after the initial ischemic insult, while other hippocampal neurons such as the dentate granule and the CA3 cells which survive ischemia expressed both mRNAs cooperatively. The dissociation was observed as early as after 8 h of reperfusion, a period far shorter than 3-4 days, when the cell death becomes pathologically evident. Thus, the dissociation may serve as a set of early biochemical markers for ischemic neuronal cell death.

KW - Heat shock cognate protein

KW - Heat shock protein

KW - Ischemia

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Dissociation of HSP70 and HSC70 heat shock mRNA inductions as an early biochemical marker of ischemic neuronal death

Abstract

Keywords

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