Disruption of Rolandic gamma-band functional connectivity by seizures is associated with motor impairments in children with epilepsy

George M. Ibrahim, Tomoyuki Akiyama, Ayako Ochi, Hiroshi Otsubo, Mary Lou Smith, Margot J. Taylor, Elizabeth Donner, James T. Rutka, O. Carter Snead, Sam M. Doesburg

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Although children with epilepsy exhibit numerous neurological and cognitive deficits, the mechanisms underlying these impairments remain unclear. Synchronization of oscillatory neural activity in the gamma frequency range (>30 Hz) is purported to be a mechanism mediating functional integration within neuronal networks supporting cognition, perception and action. Here, we tested the hypothesis that seizure-induced alterations in gamma synchronization are associated with functional deficits. By calculating synchrony among electrodes and performing graph theoretical analysis, we assessed functional connectivity and local network structure of the hand motor area of children with focal epilepsy from intracranial electroencephalographic recordings. A local decrease in inter-electrode phase synchrony in the gamma bands during ictal periods, relative to interictal periods, within the motor cortex was strongly associated with clinical motor weakness. Gamma-band ictal desychronization was a stronger predictor of deficits than the presence of the seizure-onset zone or lesion within the motor cortex. There was a positive correlation between the magnitude of ictal desychronization and impairment of motor dexterity in the contralateral, but not ipsilateral hand. There was no association between ictal desynchronization within the hand motor area and non-motor deficits. This study uniquely demonstrates that seizure-induced disturbances in cortical functional connectivity are associated with network-specific neurological deficits.

Original languageEnglish
Article numbere39326
JournalPLoS One
Volume7
Issue number6
DOIs
Publication statusPublished - Jun 21 2012
Externally publishedYes

Fingerprint

epilepsy
Motor Cortex
seizures
stroke
Epilepsy
Seizures
Stroke
hands
Hand
electrodes
Electrodes
Partial Epilepsy
Synchronization
cognition
lesions (animal)
Cognition
motor cortex

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Disruption of Rolandic gamma-band functional connectivity by seizures is associated with motor impairments in children with epilepsy. / Ibrahim, George M.; Akiyama, Tomoyuki; Ochi, Ayako; Otsubo, Hiroshi; Smith, Mary Lou; Taylor, Margot J.; Donner, Elizabeth; Rutka, James T.; Snead, O. Carter; Doesburg, Sam M.

In: PLoS One, Vol. 7, No. 6, e39326, 21.06.2012.

Research output: Contribution to journalArticle

Ibrahim, GM, Akiyama, T, Ochi, A, Otsubo, H, Smith, ML, Taylor, MJ, Donner, E, Rutka, JT, Snead, OC & Doesburg, SM 2012, 'Disruption of Rolandic gamma-band functional connectivity by seizures is associated with motor impairments in children with epilepsy', PLoS One, vol. 7, no. 6, e39326. https://doi.org/10.1371/journal.pone.0039326
Ibrahim, George M. ; Akiyama, Tomoyuki ; Ochi, Ayako ; Otsubo, Hiroshi ; Smith, Mary Lou ; Taylor, Margot J. ; Donner, Elizabeth ; Rutka, James T. ; Snead, O. Carter ; Doesburg, Sam M. / Disruption of Rolandic gamma-band functional connectivity by seizures is associated with motor impairments in children with epilepsy. In: PLoS One. 2012 ; Vol. 7, No. 6.
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