Disordered high-frequency oscillation in face processing in schizophrenia patients

Miaomiao Liu, Guangying Pei, Yinuo Peng, Changming Wang, Tianyi Yan, Jinglong Wu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Schizophrenia is a complex disorder characterized by marked social dysfunctions, but the neural mechanism underlying this deficit is unknown. To investigate whether face-specific perceptual processes are influenced in schizophrenia patients, both face detection and configural analysis were assessed in normal individuals and schizophrenia patients by recording electroencephalogram (EEG) data. Here, a face processing model was built based on the frequency oscillations, and the evoked power (theta, alpha, and beta bands) and the induced power (gamma bands) were recorded while the subjects passively viewed face and nonface images presented in upright and inverted orientations. The healthy adults showed a significant face-specific effect in the alpha, beta, and gamma bands, and an inversion effect was observed in the gamma band in the occipital lobe and right temporal lobe. Importantly, the schizophrenia patients showed face-specific deficits in the low-frequency beta and gamma bands, and the face inversion effect in the gamma band was absent from the occipital lobe. All these results revealed face-specific processing in patients due to the disorder of high-frequency EEG, providing additional evidence to enrich future studies investigating neural mechanisms and serving as a marked diagnostic basis.

Original languageEnglish
Article numbere9753
JournalMedicine (United States)
Volume97
Issue number6
DOIs
Publication statusPublished - Feb 1 2018

Fingerprint

Schizophrenia
Occipital Lobe
Electroencephalography
Temporal Lobe

Keywords

  • Configural processing
  • Evoked power
  • Face effect
  • Face-specific processing
  • Induced power
  • Inversion effect
  • Schizophrenia patients

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Disordered high-frequency oscillation in face processing in schizophrenia patients. / Liu, Miaomiao; Pei, Guangying; Peng, Yinuo; Wang, Changming; Yan, Tianyi; Wu, Jinglong.

In: Medicine (United States), Vol. 97, No. 6, e9753, 01.02.2018.

Research output: Contribution to journalArticle

Liu, Miaomiao ; Pei, Guangying ; Peng, Yinuo ; Wang, Changming ; Yan, Tianyi ; Wu, Jinglong. / Disordered high-frequency oscillation in face processing in schizophrenia patients. In: Medicine (United States). 2018 ; Vol. 97, No. 6.
@article{8f823285207146c1ae2dda6e707e96ab,
title = "Disordered high-frequency oscillation in face processing in schizophrenia patients",
abstract = "Schizophrenia is a complex disorder characterized by marked social dysfunctions, but the neural mechanism underlying this deficit is unknown. To investigate whether face-specific perceptual processes are influenced in schizophrenia patients, both face detection and configural analysis were assessed in normal individuals and schizophrenia patients by recording electroencephalogram (EEG) data. Here, a face processing model was built based on the frequency oscillations, and the evoked power (theta, alpha, and beta bands) and the induced power (gamma bands) were recorded while the subjects passively viewed face and nonface images presented in upright and inverted orientations. The healthy adults showed a significant face-specific effect in the alpha, beta, and gamma bands, and an inversion effect was observed in the gamma band in the occipital lobe and right temporal lobe. Importantly, the schizophrenia patients showed face-specific deficits in the low-frequency beta and gamma bands, and the face inversion effect in the gamma band was absent from the occipital lobe. All these results revealed face-specific processing in patients due to the disorder of high-frequency EEG, providing additional evidence to enrich future studies investigating neural mechanisms and serving as a marked diagnostic basis.",
keywords = "Configural processing, Evoked power, Face effect, Face-specific processing, Induced power, Inversion effect, Schizophrenia patients",
author = "Miaomiao Liu and Guangying Pei and Yinuo Peng and Changming Wang and Tianyi Yan and Jinglong Wu",
year = "2018",
month = "2",
day = "1",
doi = "10.1097/MD.0000000000009753",
language = "English",
volume = "97",
journal = "Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries",
issn = "0025-7974",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Disordered high-frequency oscillation in face processing in schizophrenia patients

AU - Liu, Miaomiao

AU - Pei, Guangying

AU - Peng, Yinuo

AU - Wang, Changming

AU - Yan, Tianyi

AU - Wu, Jinglong

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Schizophrenia is a complex disorder characterized by marked social dysfunctions, but the neural mechanism underlying this deficit is unknown. To investigate whether face-specific perceptual processes are influenced in schizophrenia patients, both face detection and configural analysis were assessed in normal individuals and schizophrenia patients by recording electroencephalogram (EEG) data. Here, a face processing model was built based on the frequency oscillations, and the evoked power (theta, alpha, and beta bands) and the induced power (gamma bands) were recorded while the subjects passively viewed face and nonface images presented in upright and inverted orientations. The healthy adults showed a significant face-specific effect in the alpha, beta, and gamma bands, and an inversion effect was observed in the gamma band in the occipital lobe and right temporal lobe. Importantly, the schizophrenia patients showed face-specific deficits in the low-frequency beta and gamma bands, and the face inversion effect in the gamma band was absent from the occipital lobe. All these results revealed face-specific processing in patients due to the disorder of high-frequency EEG, providing additional evidence to enrich future studies investigating neural mechanisms and serving as a marked diagnostic basis.

AB - Schizophrenia is a complex disorder characterized by marked social dysfunctions, but the neural mechanism underlying this deficit is unknown. To investigate whether face-specific perceptual processes are influenced in schizophrenia patients, both face detection and configural analysis were assessed in normal individuals and schizophrenia patients by recording electroencephalogram (EEG) data. Here, a face processing model was built based on the frequency oscillations, and the evoked power (theta, alpha, and beta bands) and the induced power (gamma bands) were recorded while the subjects passively viewed face and nonface images presented in upright and inverted orientations. The healthy adults showed a significant face-specific effect in the alpha, beta, and gamma bands, and an inversion effect was observed in the gamma band in the occipital lobe and right temporal lobe. Importantly, the schizophrenia patients showed face-specific deficits in the low-frequency beta and gamma bands, and the face inversion effect in the gamma band was absent from the occipital lobe. All these results revealed face-specific processing in patients due to the disorder of high-frequency EEG, providing additional evidence to enrich future studies investigating neural mechanisms and serving as a marked diagnostic basis.

KW - Configural processing

KW - Evoked power

KW - Face effect

KW - Face-specific processing

KW - Induced power

KW - Inversion effect

KW - Schizophrenia patients

UR - http://www.scopus.com/inward/record.url?scp=85042081649&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042081649&partnerID=8YFLogxK

U2 - 10.1097/MD.0000000000009753

DO - 10.1097/MD.0000000000009753

M3 - Article

C2 - 29419668

AN - SCOPUS:85042081649

VL - 97

JO - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries

JF - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries

SN - 0025-7974

IS - 6

M1 - e9753

ER -