TY - JOUR
T1 - Disodium Cromoglycate Inhibition of Substance P-Induced Histamine Secretion is Calcium Dependent
AU - Nishibori, Masahiro
AU - Saeki, Kiyomi
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1983
Y1 - 1983
N2 - Histamine secretion was induced by substance P, in a dose-dependent manner, from rat peritoneal mast cells, both in the presence and absence of Ca2+ in the medium, and disodium cromoglycate (DSCG) produced a dose-dependent inhibition of the histamine secretion in Ca2+-containing medium. However, in the absence of Ca2+, DSCG was ineffective or had a far weaker activity. Mg2+, Sr2+ and Ba2+ were ineffective in restoring the DSCG activity when added to medium devoid of divalent metal ions. Therefore, extracellular Ca2+ seems to be a specific requirement for the binding of DSCG to its “receptors” on the mast cell surface or some steps in the DSCG action.
AB - Histamine secretion was induced by substance P, in a dose-dependent manner, from rat peritoneal mast cells, both in the presence and absence of Ca2+ in the medium, and disodium cromoglycate (DSCG) produced a dose-dependent inhibition of the histamine secretion in Ca2+-containing medium. However, in the absence of Ca2+, DSCG was ineffective or had a far weaker activity. Mg2+, Sr2+ and Ba2+ were ineffective in restoring the DSCG activity when added to medium devoid of divalent metal ions. Therefore, extracellular Ca2+ seems to be a specific requirement for the binding of DSCG to its “receptors” on the mast cell surface or some steps in the DSCG action.
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U2 - 10.1254/jjp.33.1255
DO - 10.1254/jjp.33.1255
M3 - Article
C2 - 6199541
AN - SCOPUS:0021014861
VL - 33
SP - 1255
EP - 1261
JO - Japanese Journal of Pharmacology
JF - Japanese Journal of Pharmacology
SN - 0021-5198
IS - 6
ER -