Abstract
Histamine secretion was induced by substance P, in a dose-dependent manner, from rat peritoneal mast cells, both in the presence and absence of Ca2+ in the medium, and disodium cromoglycate (DSCG) produced a dose-dependent inhibition of the histamine secretion in Ca2+-containing medium. However, in the absence of Ca2+, DSCG was ineffective or had a far weaker activity. Mg2+, Sr2+ and Ba2+ were ineffective in restoring the DSCG activity when added to medium devoid of divalent metal ions. Therefore, extracellular Ca2+ seems to be a specific requirement for the binding of DSCG to its 'receptors' on the mast cell surface or some steps in the DSCG action.
| Original language | English |
|---|---|
| Pages (from-to) | 1255-1261 |
| Number of pages | 7 |
| Journal | Japanese Journal of Pharmacology |
| Volume | 33 |
| Issue number | 6 |
| Publication status | Published - 1983 |
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ASJC Scopus subject areas
- Pharmacology
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Disodium cromoglycate inhibition of substance P-induced histamine secretion is calcium dependent. / Nishibori, Masahiro; Saeki, K.
In: Japanese Journal of Pharmacology, Vol. 33, No. 6, 1983, p. 1255-1261.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Disodium cromoglycate inhibition of substance P-induced histamine secretion is calcium dependent
AU - Nishibori, Masahiro
AU - Saeki, K.
PY - 1983
Y1 - 1983
N2 - Histamine secretion was induced by substance P, in a dose-dependent manner, from rat peritoneal mast cells, both in the presence and absence of Ca2+ in the medium, and disodium cromoglycate (DSCG) produced a dose-dependent inhibition of the histamine secretion in Ca2+-containing medium. However, in the absence of Ca2+, DSCG was ineffective or had a far weaker activity. Mg2+, Sr2+ and Ba2+ were ineffective in restoring the DSCG activity when added to medium devoid of divalent metal ions. Therefore, extracellular Ca2+ seems to be a specific requirement for the binding of DSCG to its 'receptors' on the mast cell surface or some steps in the DSCG action.
AB - Histamine secretion was induced by substance P, in a dose-dependent manner, from rat peritoneal mast cells, both in the presence and absence of Ca2+ in the medium, and disodium cromoglycate (DSCG) produced a dose-dependent inhibition of the histamine secretion in Ca2+-containing medium. However, in the absence of Ca2+, DSCG was ineffective or had a far weaker activity. Mg2+, Sr2+ and Ba2+ were ineffective in restoring the DSCG activity when added to medium devoid of divalent metal ions. Therefore, extracellular Ca2+ seems to be a specific requirement for the binding of DSCG to its 'receptors' on the mast cell surface or some steps in the DSCG action.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021014861&partnerID=8YFLogxK
M3 - Article
C2 - 6199541
AN - SCOPUS:0021014861
VL - 33
SP - 1255
EP - 1261
JO - Japanese Journal of Pharmacology
JF - Japanese Journal of Pharmacology
SN - 0021-5198
IS - 6
ER -