Disodium cromoglycate inhibition of substance P-induced histamine secretion is calcium dependent

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Abstract

Histamine secretion was induced by substance P, in a dose-dependent manner, from rat peritoneal mast cells, both in the presence and absence of Ca2+ in the medium, and disodium cromoglycate (DSCG) produced a dose-dependent inhibition of the histamine secretion in Ca2+-containing medium. However, in the absence of Ca2+, DSCG was ineffective or had a far weaker activity. Mg2+, Sr2+ and Ba2+ were ineffective in restoring the DSCG activity when added to medium devoid of divalent metal ions. Therefore, extracellular Ca2+ seems to be a specific requirement for the binding of DSCG to its 'receptors' on the mast cell surface or some steps in the DSCG action.

Original languageEnglish
Pages (from-to)1255-1261
Number of pages7
JournalJapanese Journal of Pharmacology
Volume33
Issue number6
Publication statusPublished - 1983

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ASJC Scopus subject areas

  • Pharmacology

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