Disodium Cromoglycate Inhibition of Substance P-Induced Histamine Secretion is Calcium Dependent

Masahiro Nishibori, Kiyomi Saeki

Research output: Contribution to journalArticle

Abstract

Histamine secretion was induced by substance P, in a dose-dependent manner, from rat peritoneal mast cells, both in the presence and absence of Ca2+ in the medium, and disodium cromoglycate (DSCG) produced a dose-dependent inhibition of the histamine secretion in Ca2+-containing medium. However, in the absence of Ca2+, DSCG was ineffective or had a far weaker activity. Mg2+, Sr2+ and Ba2+ were ineffective in restoring the DSCG activity when added to medium devoid of divalent metal ions. Therefore, extracellular Ca2+ seems to be a specific requirement for the binding of DSCG to its “receptors” on the mast cell surface or some steps in the DSCG action.

Original languageEnglish
Pages (from-to)1255-1261
Number of pages7
Journalthe japanese journal of pharmacology
Volume33
Issue number6
DOIs
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Pharmacology

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