@inproceedings{eb3bc7f10b8141889c1ecb22fd285f00,
title = "Discrimination of target proteins using arrayed fluorescent liposomes incorporated with cholesterol by principal component analysis",
abstract = "A bio array sensing system is newly composed utilizing different phospholipid liposomes encapsulating fluorescent molecules. We have confirmed a high output intensity of fluorescence emission due to the characteristics dependent on the concentration of fluorescent molecules when the fluorescent molecules leak from inside of the liposome through perturbed lipid membrane. After measuring a whole array image of fluorescence emission output from every element of liposome sensor by a new CMOS imager system, the outputs of fluorescence emission from all the elements were analyzed by a statistical method of principal component analysis (PCA). It was found from obtained PCA plots that different species of proteins with several concentrations were discriminated with high cumulative contribution ratio.",
keywords = "Array, Biosensor, Cholesterol, Fluorescence, Liposome, Principal Component Analysis, Protein",
author = "R. Imamura and Z. Zhang and T. Yoshikawa and N. Murata and K. Yamashita and M. Fukuzawa and M. Noda and T. Shimanouchi",
note = "Funding Information: This research was partly supported by a Grant-in-Aid for Scientific Research (KAKENHI Grant No. 25249048) from the Japan Society for the Promotion of Science (JSPS) Publisher Copyright: {\textcopyright} 2015 IEEE.; 14th IEEE SENSORS ; Conference date: 01-11-2015 Through 04-11-2015",
year = "2015",
month = dec,
day = "31",
doi = "10.1109/ICSENS.2015.7370493",
language = "English",
series = "2015 IEEE SENSORS - Proceedings",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
booktitle = "2015 IEEE SENSORS - Proceedings",
}