Discriminant analysis of native thoracic aortic curvature

Risk prediction for endoleak formation after thoracic endovascular aortic repair

Hazuki Nakatamari, Takuya Ueda, Fumio Ishioka, Bhargav Raman, Koji Kurihara, Geoffrey D. Rubin, Hisao Ito, Daniel Y. Sze

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Purpose: To determine the association of native thoracic aortic curvature measured from computed tomographic (CT) angiography categorized by discriminant analysis with the development of endoleaks after thoracic endovascular aortic repair (EVAR). Materials and Methods: Forty patients (28 men, 12 women; mean age, 74 y; range, 4089 y) with aortic diseases treated with thoracic EVAR were evaluated. Diseases treated included atherosclerotic aneurysm (n = 27), penetrating atherosclerotic ulcer (n = 4), intramural hematoma (n = 3), mycotic aneurysm (n = 3), and anastomotic pseudoaneurysm (n = 3). Quantitative analysis of native aortic morphology was performed on preprocedural CT angiograms with an original customized computer program, and regional curvature indices in each anatomic segment of the aorta were calculated. Patterns of native thoracic aortic morphology were analyzed by discriminant analysis. The association between the morphologic pattern of the aorta and the presence and type of endoleak was assessed. Results: After leave-one-out cross-validation methods had been applied, the sensitivity, specificity, and accuracy to detect endoleak formation in a new population group by discriminant analysis of the patterns of native aortic curvature were estimated as 84.0%, 58.8%, and 73.8%, respectively. Compared with the no-endoleak group, the type Ia endoleak group had greater curvature at the aortic arch, the type Ib endoleak group had greater curvature at the thoracoabdominal junction, and the type III endoleak group had greater curvature in the midportion of the descending aorta. Conclusions: Discriminant analysis of native thoracic aortic morphology measured from CT angiography is a useful tool to predict the risk of endoleak formation after thoracic EVAR and should be implemented during treatment planning and follow-up.

Original languageEnglish
Pages (from-to)974-979
Number of pages6
JournalJournal of Vascular and Interventional Radiology
Volume22
Issue number7
DOIs
Publication statusPublished - Jul 2011

Fingerprint

Endoleak
Discriminant Analysis
Thorax
Angiography
Thoracic Aorta
Aorta
Infected Aneurysm
Aortic Diseases
False Aneurysm
Population Groups
Hematoma
Ulcer
Aneurysm
Software
Sensitivity and Specificity

Keywords

  • endovascular aneurysm repair
  • EVAR
  • TEVAR
  • thoracic endovascular aortic repair

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Discriminant analysis of native thoracic aortic curvature : Risk prediction for endoleak formation after thoracic endovascular aortic repair. / Nakatamari, Hazuki; Ueda, Takuya; Ishioka, Fumio; Raman, Bhargav; Kurihara, Koji; Rubin, Geoffrey D.; Ito, Hisao; Sze, Daniel Y.

In: Journal of Vascular and Interventional Radiology, Vol. 22, No. 7, 07.2011, p. 974-979.

Research output: Contribution to journalArticle

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title = "Discriminant analysis of native thoracic aortic curvature: Risk prediction for endoleak formation after thoracic endovascular aortic repair",
abstract = "Purpose: To determine the association of native thoracic aortic curvature measured from computed tomographic (CT) angiography categorized by discriminant analysis with the development of endoleaks after thoracic endovascular aortic repair (EVAR). Materials and Methods: Forty patients (28 men, 12 women; mean age, 74 y; range, 4089 y) with aortic diseases treated with thoracic EVAR were evaluated. Diseases treated included atherosclerotic aneurysm (n = 27), penetrating atherosclerotic ulcer (n = 4), intramural hematoma (n = 3), mycotic aneurysm (n = 3), and anastomotic pseudoaneurysm (n = 3). Quantitative analysis of native aortic morphology was performed on preprocedural CT angiograms with an original customized computer program, and regional curvature indices in each anatomic segment of the aorta were calculated. Patterns of native thoracic aortic morphology were analyzed by discriminant analysis. The association between the morphologic pattern of the aorta and the presence and type of endoleak was assessed. Results: After leave-one-out cross-validation methods had been applied, the sensitivity, specificity, and accuracy to detect endoleak formation in a new population group by discriminant analysis of the patterns of native aortic curvature were estimated as 84.0{\%}, 58.8{\%}, and 73.8{\%}, respectively. Compared with the no-endoleak group, the type Ia endoleak group had greater curvature at the aortic arch, the type Ib endoleak group had greater curvature at the thoracoabdominal junction, and the type III endoleak group had greater curvature in the midportion of the descending aorta. Conclusions: Discriminant analysis of native thoracic aortic morphology measured from CT angiography is a useful tool to predict the risk of endoleak formation after thoracic EVAR and should be implemented during treatment planning and follow-up.",
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AU - Nakatamari, Hazuki

AU - Ueda, Takuya

AU - Ishioka, Fumio

AU - Raman, Bhargav

AU - Kurihara, Koji

AU - Rubin, Geoffrey D.

AU - Ito, Hisao

AU - Sze, Daniel Y.

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N2 - Purpose: To determine the association of native thoracic aortic curvature measured from computed tomographic (CT) angiography categorized by discriminant analysis with the development of endoleaks after thoracic endovascular aortic repair (EVAR). Materials and Methods: Forty patients (28 men, 12 women; mean age, 74 y; range, 4089 y) with aortic diseases treated with thoracic EVAR were evaluated. Diseases treated included atherosclerotic aneurysm (n = 27), penetrating atherosclerotic ulcer (n = 4), intramural hematoma (n = 3), mycotic aneurysm (n = 3), and anastomotic pseudoaneurysm (n = 3). Quantitative analysis of native aortic morphology was performed on preprocedural CT angiograms with an original customized computer program, and regional curvature indices in each anatomic segment of the aorta were calculated. Patterns of native thoracic aortic morphology were analyzed by discriminant analysis. The association between the morphologic pattern of the aorta and the presence and type of endoleak was assessed. Results: After leave-one-out cross-validation methods had been applied, the sensitivity, specificity, and accuracy to detect endoleak formation in a new population group by discriminant analysis of the patterns of native aortic curvature were estimated as 84.0%, 58.8%, and 73.8%, respectively. Compared with the no-endoleak group, the type Ia endoleak group had greater curvature at the aortic arch, the type Ib endoleak group had greater curvature at the thoracoabdominal junction, and the type III endoleak group had greater curvature in the midportion of the descending aorta. Conclusions: Discriminant analysis of native thoracic aortic morphology measured from CT angiography is a useful tool to predict the risk of endoleak formation after thoracic EVAR and should be implemented during treatment planning and follow-up.

AB - Purpose: To determine the association of native thoracic aortic curvature measured from computed tomographic (CT) angiography categorized by discriminant analysis with the development of endoleaks after thoracic endovascular aortic repair (EVAR). Materials and Methods: Forty patients (28 men, 12 women; mean age, 74 y; range, 4089 y) with aortic diseases treated with thoracic EVAR were evaluated. Diseases treated included atherosclerotic aneurysm (n = 27), penetrating atherosclerotic ulcer (n = 4), intramural hematoma (n = 3), mycotic aneurysm (n = 3), and anastomotic pseudoaneurysm (n = 3). Quantitative analysis of native aortic morphology was performed on preprocedural CT angiograms with an original customized computer program, and regional curvature indices in each anatomic segment of the aorta were calculated. Patterns of native thoracic aortic morphology were analyzed by discriminant analysis. The association between the morphologic pattern of the aorta and the presence and type of endoleak was assessed. Results: After leave-one-out cross-validation methods had been applied, the sensitivity, specificity, and accuracy to detect endoleak formation in a new population group by discriminant analysis of the patterns of native aortic curvature were estimated as 84.0%, 58.8%, and 73.8%, respectively. Compared with the no-endoleak group, the type Ia endoleak group had greater curvature at the aortic arch, the type Ib endoleak group had greater curvature at the thoracoabdominal junction, and the type III endoleak group had greater curvature in the midportion of the descending aorta. Conclusions: Discriminant analysis of native thoracic aortic morphology measured from CT angiography is a useful tool to predict the risk of endoleak formation after thoracic EVAR and should be implemented during treatment planning and follow-up.

KW - endovascular aneurysm repair

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KW - TEVAR

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