Abstract
Previous studies demonstrated that type I collagen, a major component of the extracellular matrix, could influence the differentiation and function of leukocytes; however, it is not clear whether those effects of collagen were based on its interaction with the classic collagen receptors, α1β1 and α2β1 integrins. We recently detected significant upregulation of discoidin domain receptor 1 (DDR1), a new class of collagen receptor, in human leukocytes, including neutrophils, monocytes, and lymphocytes, in vitro, leading to the hypothesis that the leukocyte-activating effects of collagen might be owing to its interaction with DDR1. In this review, we summarize our recent findings demonstrating that DDR1-collagen interaction facilitates the adhesion, migration, differentiation/maturation, and cytokine/chemokine production of leukocytes. We also describe the intracellular signaling pathways activated by DDR1 interaction with collagen.
Original language | English |
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Pages (from-to) | 219-229 |
Number of pages | 11 |
Journal | Immunologic Research |
Volume | 31 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2005 |
Externally published | Yes |
Keywords
- Cell differentiation
- Cell migration
- Cell signaling
- Collagen
- Dendritic cells
- Discoidin domain receptor 1
- Macrophages
ASJC Scopus subject areas
- Immunology