Disappearance of pulmonary metastases by OK-432 treatment in a case of hepatocellular carcinoma.

N. Hino, T. Higashi, T. Ueki, H. Nakatsukasa, S. Ooguchi, Kozo Ashida, K. Fujio, Akinobu Takaki, T. Yonei, T. Hasui

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We report here a case of hepatocellular carcinoma (HCC) with multiple lung metastases, which were disappeared by treatment of OK-432. The patient was a 65-year-old man and was diagnosed in 1986 with a small (17 x 11 mm) HCC in the anterior-superior segment of the liver. A part of the right hepatic lobe including the tumor was surgically removed, and transarterial injections of adriamycin (10 mg/week) and subcutaneous injections of OK-432 (10 KE/week) were given. Two and a half years later, recurrence of HCC in the liver and its invasion to vena cava inferior (IVC) were found. OK-432 administration was then stopped and percutaneous ethanol injection therapy (PEIT) was performed 10 times. Six months later, the PEIT was effective and the liver tumor with IVC invasion diminished. However, multiple lung metastases were visible on roentgenograms of the chest, and serum alphafetoprotein (AFP) concentration increased to 50,000 ng/ml. The OK-432 treatment resumed. After 6 months of OK-432 treatment, the multiple lung metastases were disappeared and the serum AFP level decreased to 100 ng/ml. At present, the patient is surviving without any sign of recurrence in either the liver or the lung. The clinical course of this case suggests that OK-432 might have effectively treated lung metastases of HCC, although the exact mechanisms are at present unclear.

Original languageEnglish
Pages (from-to)289-292
Number of pages4
JournalActa Medica Okayama
Volume47
Issue number4
Publication statusPublished - Aug 1993

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Picibanil
Hepatocellular Carcinoma
Neoplasm Metastasis
Liver
Lung
Injections
Tumors
Ethanol
Therapeutics
Recurrence
Inferior Vena Cava
Subcutaneous Injections
Serum
Doxorubicin
Neoplasms
Thorax

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Hino, N., Higashi, T., Ueki, T., Nakatsukasa, H., Ooguchi, S., Ashida, K., ... Hasui, T. (1993). Disappearance of pulmonary metastases by OK-432 treatment in a case of hepatocellular carcinoma. Acta Medica Okayama, 47(4), 289-292.

Disappearance of pulmonary metastases by OK-432 treatment in a case of hepatocellular carcinoma. / Hino, N.; Higashi, T.; Ueki, T.; Nakatsukasa, H.; Ooguchi, S.; Ashida, Kozo; Fujio, K.; Takaki, Akinobu; Yonei, T.; Hasui, T.

In: Acta Medica Okayama, Vol. 47, No. 4, 08.1993, p. 289-292.

Research output: Contribution to journalArticle

Hino, N, Higashi, T, Ueki, T, Nakatsukasa, H, Ooguchi, S, Ashida, K, Fujio, K, Takaki, A, Yonei, T & Hasui, T 1993, 'Disappearance of pulmonary metastases by OK-432 treatment in a case of hepatocellular carcinoma.', Acta Medica Okayama, vol. 47, no. 4, pp. 289-292.
Hino N, Higashi T, Ueki T, Nakatsukasa H, Ooguchi S, Ashida K et al. Disappearance of pulmonary metastases by OK-432 treatment in a case of hepatocellular carcinoma. Acta Medica Okayama. 1993 Aug;47(4):289-292.
Hino, N. ; Higashi, T. ; Ueki, T. ; Nakatsukasa, H. ; Ooguchi, S. ; Ashida, Kozo ; Fujio, K. ; Takaki, Akinobu ; Yonei, T. ; Hasui, T. / Disappearance of pulmonary metastases by OK-432 treatment in a case of hepatocellular carcinoma. In: Acta Medica Okayama. 1993 ; Vol. 47, No. 4. pp. 289-292.
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