Disappearance of an activated EGFR mutation after treatment with EGFR tyrosine kinase inhibitors

Yoshihiro Honda, Nagio Takigawa, Soichiro Fushimi, Nobuaki Ochi, Toshio Kubo, Saeko Ozaki, Mitsune Tanimoto, Katsuyuki Kiura

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A 34-year-old Japanese woman presented with left supraclavicular lymph node swelling. Computed tomography scans revealed a mass on the left lower lobe, pulmonary nodules, and pleural effusion. A lymph node biopsy revealed large-cell carcinoma with an epidermal growth factor receptor (EGFR) deletion mutation, L747-T751 in exon 19. Although malignant pleural effusions carried the same EGFR mutation, progressive pleural effusions after treatment with chemotherapy, gefitinib, and erlotinib did not show any EGFR mutation. A cell line established from the pleural effusion 3 days before the patient expired also did not harbor the EGFR mutation. Histological sections of the lymph node of the patient were similar to those of the xenograft tumor of the cell line. There may be genetic heterogeneity in EGFR mutant tumors.

Original languageEnglish
Pages (from-to)121-124
Number of pages4
JournalLung Cancer
Volume78
Issue number1
DOIs
Publication statusPublished - Oct 2012

Fingerprint

Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Pleural Effusion
Mutation
Lymph Nodes
Malignant Pleural Effusion
Therapeutics
Large Cell Carcinoma
Genetic Heterogeneity
Sequence Deletion
Tumor Cell Line
Heterografts
Exons
Tomography
Biopsy
Drug Therapy
Cell Line
Lung
Neoplasms

Keywords

  • Cell line
  • Epidermal growth factor receptor
  • Large-cell carcinoma
  • Non-small-cell lung cancer

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

Cite this

Disappearance of an activated EGFR mutation after treatment with EGFR tyrosine kinase inhibitors. / Honda, Yoshihiro; Takigawa, Nagio; Fushimi, Soichiro; Ochi, Nobuaki; Kubo, Toshio; Ozaki, Saeko; Tanimoto, Mitsune; Kiura, Katsuyuki.

In: Lung Cancer, Vol. 78, No. 1, 10.2012, p. 121-124.

Research output: Contribution to journalArticle

Honda, Yoshihiro ; Takigawa, Nagio ; Fushimi, Soichiro ; Ochi, Nobuaki ; Kubo, Toshio ; Ozaki, Saeko ; Tanimoto, Mitsune ; Kiura, Katsuyuki. / Disappearance of an activated EGFR mutation after treatment with EGFR tyrosine kinase inhibitors. In: Lung Cancer. 2012 ; Vol. 78, No. 1. pp. 121-124.
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