Facile addition of primary alkyl Gridnard reagents to vinylsilanes has been realized for the first time by exploiting the directing effect of a 2-pridyl group on silicon [Eq. (1)]. Three-component coupling reactions of a Grignard reagent, the vinylsilane, and an electrophile, followed by oxidative removal of the 2-pyridyldimethylsilyl group with H2O2 furnishes various secondary alcohols in excellent overall yields.
|Number of pages||3|
|Journal||Angewandte Chemie - International Edition|
|Publication status||Published - Jun 18 2001|
- Multicomponent reactions
- Synthetic methods
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