Abstract
Facile addition of primary alkyl Gridnard reagents to vinylsilanes has been realized for the first time by exploiting the directing effect of a 2-pridyl group on silicon [Eq. (1)]. Three-component coupling reactions of a Grignard reagent, the vinylsilane, and an electrophile, followed by oxidative removal of the 2-pyridyldimethylsilyl group with H2O2 furnishes various secondary alcohols in excellent overall yields.
Original language | English |
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Pages (from-to) | 2337-2339 |
Number of pages | 3 |
Journal | Angewandte Chemie - International Edition |
Volume | 40 |
Issue number | 12 |
DOIs | |
Publication status | Published - Jun 18 2001 |
Externally published | Yes |
Keywords
- Alcohols
- Magnesium
- Multicomponent reactions
- Silicon
- Synthetic methods
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)