Directed intermolecular carbomagnesation across vinylsilanes: 2-PyMe2Si group as a removable directing group

Kenichiro Itami, Koichi Mitsudo, Jun Ichi Yoshida

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


Facile addition of primary alkyl Gridnard reagents to vinylsilanes has been realized for the first time by exploiting the directing effect of a 2-pridyl group on silicon [Eq. (1)]. Three-component coupling reactions of a Grignard reagent, the vinylsilane, and an electrophile, followed by oxidative removal of the 2-pyridyldimethylsilyl group with H2O2 furnishes various secondary alcohols in excellent overall yields.

Original languageEnglish
Pages (from-to)2337-2339
Number of pages3
JournalAngewandte Chemie - International Edition
Issue number12
Publication statusPublished - Jun 18 2001
Externally publishedYes


  • Alcohols
  • Magnesium
  • Multicomponent reactions
  • Silicon
  • Synthetic methods

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


Dive into the research topics of 'Directed intermolecular carbomagnesation across vinylsilanes: 2-PyMe<sub>2</sub>Si group as a removable directing group'. Together they form a unique fingerprint.

Cite this