Directed evolution of a synthetic RNA-protein module to create a new translational switch

Tomoaki Hara; Hirohide Saito; Tan Inoue

doi:10.1039/c3cc38688k

Directed evolution of a synthetic RNA-protein module to create a new translational switch

Tomoaki Hara, Hirohide Saito, Tan Inoue

Graduate School of Natural Science and Technology

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

A synthetic RNP-binding module was developed to produce an alternative translational switch: an in vitro selection experiment targeting a derivative of L7Ae protein (L7KK) identified a new H23 RNA aptamer that binds tightly to both L7KK and L7Ae. The switch serves as a translational OFF switch for constructing a NOR gate.

Original language	English
Pages (from-to)	3833-3835
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	37
DOIs	https://doi.org/10.1039/c3cc38688k
Publication status	Published - Apr 11 2013

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "A synthetic RNP-binding module was developed to produce an alternative translational switch: an in vitro selection experiment targeting a derivative of L7Ae protein (L7KK) identified a new H23 RNA aptamer that binds tightly to both L7KK and L7Ae. The switch serves as a translational OFF switch for constructing a NOR gate.",

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Directed evolution of a synthetic RNA-protein module to create a new translational switch

Abstract

ASJC Scopus subject areas

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