Directed evolution of a synthetic RNA-protein module to create a new translational switch

Tomoaki Hara, Hirohide Saito, Tan Inoue

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

A synthetic RNP-binding module was developed to produce an alternative translational switch: an in vitro selection experiment targeting a derivative of L7Ae protein (L7KK) identified a new H23 RNA aptamer that binds tightly to both L7KK and L7Ae. The switch serves as a translational OFF switch for constructing a NOR gate.

Original languageEnglish
Pages (from-to)3833-3835
Number of pages3
JournalChemical Communications
Volume49
Issue number37
DOIs
Publication statusPublished - Apr 11 2013

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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