Direct targeting of proteins to lipid droplets demonstrated by time-lapse live cell imaging

Torahiko Tanaka, Kazumichi Kuroda, Masanori Ikeda, Nobuyuki Kato, Kazufumi Shimizu, Makoto Makishima

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A protein that specifically targets lipid droplets (LDs) was created by connecting two domains of nonstructural protein 4B containing amphipathic helices from hepatitis C virus. We demonstrated its direct targeting and accumulation to the LD surface by time-lapse live cell imaging, comparable to those observed with adipose differentiation-related protein.

Original languageEnglish
Pages (from-to)620-623
Number of pages4
JournalJournal of Bioscience and Bioengineering
Volume116
Issue number5
DOIs
Publication statusPublished - Nov 1 2013

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Keywords

  • Adipose differentiation-related protein
  • Hepatitis C virus
  • Lipid droplets
  • Nonstructural protein 4B
  • Time-lapse imaging

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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