Direct Intracerebral Invasion from Skull Metastasis of Large Cell Lung Cancer

Akio Hiraki, Masahiro Tabata, Hiroshi Ueoka, Katsuyuki Kiura, Takuo Shibayama, Hiromichi Yamane, Mine Harada

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A 56-year-old Japanese woman was referred to us for the treatment of lung cancer. On admission, the patient showed multiple bone metastases, including the skull, without brain metastasis. During chemoradiotherapy for the primary tumor and bone metastasis involving the thoracic spine, she suffered a fatal intracerebral hemorrhage. Since the patient had no risk factors for intracerebral hemorrhage, the skull bone metastasis was thought to be responsible for this event. At autopsy, penetration of the metastatic tumor from the skull bone into the dura, with direct invasion of the brain tissue, was confirmed histologically. A hematoma also was identified at the same site adjacent to the skull bone metastasis. To our knowledge, direct tumor invasion to the brain from a skull metastasis of non-small cell lung cancer has not been previously reported.

Original languageEnglish
Pages (from-to)720-723
Number of pages4
JournalInternal Medicine
Volume36
Issue number10
Publication statusPublished - 1997

Fingerprint

Skull
Lung Neoplasms
Neoplasm Metastasis
Bone and Bones
Cerebral Hemorrhage
Brain
Neoplasms
Chemoradiotherapy
Non-Small Cell Lung Carcinoma
Hematoma
Autopsy
Spine
Thorax

Keywords

  • Adverse effect
  • Non-small cell lung cancer

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Hiraki, A., Tabata, M., Ueoka, H., Kiura, K., Shibayama, T., Yamane, H., & Harada, M. (1997). Direct Intracerebral Invasion from Skull Metastasis of Large Cell Lung Cancer. Internal Medicine, 36(10), 720-723.

Direct Intracerebral Invasion from Skull Metastasis of Large Cell Lung Cancer. / Hiraki, Akio; Tabata, Masahiro; Ueoka, Hiroshi; Kiura, Katsuyuki; Shibayama, Takuo; Yamane, Hiromichi; Harada, Mine.

In: Internal Medicine, Vol. 36, No. 10, 1997, p. 720-723.

Research output: Contribution to journalArticle

Hiraki, A, Tabata, M, Ueoka, H, Kiura, K, Shibayama, T, Yamane, H & Harada, M 1997, 'Direct Intracerebral Invasion from Skull Metastasis of Large Cell Lung Cancer', Internal Medicine, vol. 36, no. 10, pp. 720-723.
Hiraki, Akio ; Tabata, Masahiro ; Ueoka, Hiroshi ; Kiura, Katsuyuki ; Shibayama, Takuo ; Yamane, Hiromichi ; Harada, Mine. / Direct Intracerebral Invasion from Skull Metastasis of Large Cell Lung Cancer. In: Internal Medicine. 1997 ; Vol. 36, No. 10. pp. 720-723.
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