Direct examination of chromosomal clustering of organ-specific genes in the chordate Ciona intestinalis

Eiichi Shoguchi, Mayuko Hamada, Manabu Fujie, Nori Satoh

Research output: Contribution to journalLetter

7 Citations (Scopus)

Abstract

One of challenges in the field of developmental biology is to understand how spatially and/or temporally coordinated expression of genes is controlled at the chromosomal level. It remains controversial whether genes expressed in a given tissue are randomly distributed throughout a given animal genome, or instead resolve into clusters. Here we used microarray analysis to identify more than 1,700 genes that are expressed preferentially in each of 11 organs of the chordate Ciona intestinalis adult, and determined the location of these genes on the 14 pairs of Ciona chromosomes. In spite of extensive mapped gene analysis, we only confirmed small clusters containing two or three genes. Our result indicates that organ-specific genes are distributed rather evenly all over chromosomes, suggesting that the notion of clustering of organ-specific genes in animal genomes is not generally applicable to this chordate. genesis 49:662-672, 2011.

Original languageEnglish
Pages (from-to)662-672
Number of pages11
JournalGenesis
Volume49
Issue number8
DOIs
Publication statusPublished - Aug 2011
Externally publishedYes

Fingerprint

Ciona intestinalis
Chordata
Cluster Analysis
Genes
Chromosomes
Genome
Developmental Biology
Microarray Analysis
Gene Expression

Keywords

  • Chromosomal clustering
  • Ciona intestinalis
  • Expression control
  • Organ-specific genes

ASJC Scopus subject areas

  • Endocrinology
  • Cell Biology
  • Genetics

Cite this

Direct examination of chromosomal clustering of organ-specific genes in the chordate Ciona intestinalis. / Shoguchi, Eiichi; Hamada, Mayuko; Fujie, Manabu; Satoh, Nori.

In: Genesis, Vol. 49, No. 8, 08.2011, p. 662-672.

Research output: Contribution to journalLetter

Shoguchi, Eiichi ; Hamada, Mayuko ; Fujie, Manabu ; Satoh, Nori. / Direct examination of chromosomal clustering of organ-specific genes in the chordate Ciona intestinalis. In: Genesis. 2011 ; Vol. 49, No. 8. pp. 662-672.
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