Abstract
Insulin-like androgenic gland factor (IAG) is presumed to be a sex differentiation factor so-called androgenic gland hormone (AGH) in decapod crustacean, although the function of IAG peptide has not yet been reported. In this study, we synthesized IAG from the prawn, Marsupenaeus japonicus, and its function was assessed by an in vitro bioassay. As a result, IAG with the insulin-type disulfide bond arrangement showed biological activity, whereas its disulfide isomer did not. These results strongly suggest that the native IAG peptide has an insulin-type disulfide, and it is the decapod AGH.
Original language | English |
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Pages (from-to) | 5783-5789 |
Number of pages | 7 |
Journal | Bioorganic and Medicinal Chemistry |
Volume | 22 |
Issue number | 21 |
DOIs | |
Publication status | Published - Nov 1 2014 |
Keywords
- Crustacean
- Glycopeptide
- Insulin-like androgenic gland factor
- Marsupenaeus japonicus
- Solid-phase peptide synthesis
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry