Abstract
Expression of dopamine receptors (DA-Rs) in astrocytes was examined in vitro and in vivo using primary cultured astrocytes and brain slices from rat basal ganglia. Astrocytes from basal ganglia expressed DA D1-, D3-, D4- and D5-receptors and D4-mediated signal transduction in response to DA, suggesting possible involvement of astrocytes in the pharmacological action of atypical antipsychotic drugs and in DA response in some neurological diseases.
Original language | English |
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Pages (from-to) | 120-123 |
Number of pages | 4 |
Journal | Brain Research |
Volume | 1029 |
Issue number | 1 |
DOIs | |
Publication status | Published - Dec 10 2004 |
Keywords
- Astrocyte
- Dopamine
- Dopamine antagonist
- Dopamine receptor
- cAMP responsive element binding protein
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology