Abstract
Expression of dopamine receptors (DA-Rs) in astrocytes was examined in vitro and in vivo using primary cultured astrocytes and brain slices from rat basal ganglia. Astrocytes from basal ganglia expressed DA D1-, D3-, D4- and D5-receptors and D4-mediated signal transduction in response to DA, suggesting possible involvement of astrocytes in the pharmacological action of atypical antipsychotic drugs and in DA response in some neurological diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 120-123 |
| Number of pages | 4 |
| Journal | Brain Research |
| Volume | 1029 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Dec 10 2004 |
Keywords
- Astrocyte
- Dopamine
- Dopamine antagonist
- Dopamine receptor
- cAMP responsive element binding protein
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology
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Cite this
Miyazaki, I., Asanuma, M., Diaz-Corrales, F. J., Miyoshi, K., & Ogawa, N. (2004). Direct evidence for expression of dopamine receptors in astrocytes from basal ganglia. Brain Research, 1029(1), 120-123. https://doi.org/10.1016/j.brainres.2004.09.014