Abstract
Expression of dopamine receptors (DA-Rs) in astrocytes was examined in vitro and in vivo using primary cultured astrocytes and brain slices from rat basal ganglia. Astrocytes from basal ganglia expressed DA D1-, D3-, D4- and D5-receptors and D4-mediated signal transduction in response to DA, suggesting possible involvement of astrocytes in the pharmacological action of atypical antipsychotic drugs and in DA response in some neurological diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 120-123 |
| Number of pages | 4 |
| Journal | Brain Research |
| Volume | 1029 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Dec 10 2004 |
Fingerprint
Keywords
- Astrocyte
- cAMP responsive element binding protein
- Dopamine
- Dopamine antagonist
- Dopamine receptor
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Direct evidence for expression of dopamine receptors in astrocytes from basal ganglia. / Miyazaki, Ikuko; Asanuma, Masato; Diaz-Corrales, Francisco J.; Miyoshi, Ko; Ogawa, Norio.
In: Brain Research, Vol. 1029, No. 1, 10.12.2004, p. 120-123.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Direct evidence for expression of dopamine receptors in astrocytes from basal ganglia
AU - Miyazaki, Ikuko
AU - Asanuma, Masato
AU - Diaz-Corrales, Francisco J.
AU - Miyoshi, Ko
AU - Ogawa, Norio
PY - 2004/12/10
Y1 - 2004/12/10
N2 - Expression of dopamine receptors (DA-Rs) in astrocytes was examined in vitro and in vivo using primary cultured astrocytes and brain slices from rat basal ganglia. Astrocytes from basal ganglia expressed DA D1-, D3-, D4- and D5-receptors and D4-mediated signal transduction in response to DA, suggesting possible involvement of astrocytes in the pharmacological action of atypical antipsychotic drugs and in DA response in some neurological diseases.
AB - Expression of dopamine receptors (DA-Rs) in astrocytes was examined in vitro and in vivo using primary cultured astrocytes and brain slices from rat basal ganglia. Astrocytes from basal ganglia expressed DA D1-, D3-, D4- and D5-receptors and D4-mediated signal transduction in response to DA, suggesting possible involvement of astrocytes in the pharmacological action of atypical antipsychotic drugs and in DA response in some neurological diseases.
KW - Astrocyte
KW - cAMP responsive element binding protein
KW - Dopamine
KW - Dopamine antagonist
KW - Dopamine receptor
UR - http://www.scopus.com/inward/record.url?scp=7744242098&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=7744242098&partnerID=8YFLogxK
U2 - 10.1016/j.brainres.2004.09.014
DO - 10.1016/j.brainres.2004.09.014
M3 - Article
C2 - 15533323
AN - SCOPUS:7744242098
VL - 1029
SP - 120
EP - 123
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1
ER -