Direct evidence for expression of dopamine receptors in astrocytes from basal ganglia

Ikuko Miyazaki, Masato Asanuma, Francisco J. Diaz-Corrales, Ko Miyoshi, Norio Ogawa

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Expression of dopamine receptors (DA-Rs) in astrocytes was examined in vitro and in vivo using primary cultured astrocytes and brain slices from rat basal ganglia. Astrocytes from basal ganglia expressed DA D1-, D3-, D4- and D5-receptors and D4-mediated signal transduction in response to DA, suggesting possible involvement of astrocytes in the pharmacological action of atypical antipsychotic drugs and in DA response in some neurological diseases.

Original languageEnglish
Pages (from-to)120-123
Number of pages4
JournalBrain Research
Volume1029
Issue number1
DOIs
Publication statusPublished - Dec 10 2004

Keywords

  • Astrocyte
  • Dopamine
  • Dopamine antagonist
  • Dopamine receptor
  • cAMP responsive element binding protein

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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