Direct evidence for expression of dopamine receptors in astrocytes from basal ganglia

Ikuko Miyazaki; Masato Asanuma; Francisco J. Diaz-Corrales; Ko Miyoshi; Norio Ogawa

doi:10.1016/j.brainres.2004.09.014

Direct evidence for expression of dopamine receptors in astrocytes from basal ganglia

Ikuko Miyazaki, Masato Asanuma, Francisco J. Diaz-Corrales, Ko Miyoshi, Norio Ogawa

Research output: Contribution to journal › Article › peer-review

94 Citations (Scopus)

Abstract

Expression of dopamine receptors (DA-Rs) in astrocytes was examined in vitro and in vivo using primary cultured astrocytes and brain slices from rat basal ganglia. Astrocytes from basal ganglia expressed DA D1-, D3-, D4- and D5-receptors and D4-mediated signal transduction in response to DA, suggesting possible involvement of astrocytes in the pharmacological action of atypical antipsychotic drugs and in DA response in some neurological diseases.

Original language	English
Pages (from-to)	120-123
Number of pages	4
Journal	Brain Research
Volume	1029
Issue number	1
DOIs	https://doi.org/10.1016/j.brainres.2004.09.014
Publication status	Published - Dec 10 2004

Keywords

Astrocyte
Dopamine
Dopamine antagonist
Dopamine receptor
cAMP responsive element binding protein

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/j.brainres.2004.09.014

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title = "Direct evidence for expression of dopamine receptors in astrocytes from basal ganglia",

abstract = "Expression of dopamine receptors (DA-Rs) in astrocytes was examined in vitro and in vivo using primary cultured astrocytes and brain slices from rat basal ganglia. Astrocytes from basal ganglia expressed DA D1-, D3-, D4- and D5-receptors and D4-mediated signal transduction in response to DA, suggesting possible involvement of astrocytes in the pharmacological action of atypical antipsychotic drugs and in DA response in some neurological diseases.",

keywords = "Astrocyte, Dopamine, Dopamine antagonist, Dopamine receptor, cAMP responsive element binding protein",

author = "Ikuko Miyazaki and Masato Asanuma and Diaz-Corrales, {Francisco J.} and Ko Miyoshi and Norio Ogawa",

note = "Funding Information: This work was supported in part by Grants-in-Aid for Young Scientists (B) and for Scientific Research (C) from the Japanese Ministry of Education, Culture, Sports, and Technology, and by Grants-in-Aid for Research on Psychiatric and Neurological Diseases and Mental Health, Comprehensive Research on Aging and Health, and Research on Pharmaceutical and Medical Safety from the Japanese Ministry of Health, Labour and Welfare.",

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doi = "10.1016/j.brainres.2004.09.014",

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T1 - Direct evidence for expression of dopamine receptors in astrocytes from basal ganglia

AU - Miyazaki, Ikuko

AU - Asanuma, Masato

AU - Diaz-Corrales, Francisco J.

AU - Miyoshi, Ko

AU - Ogawa, Norio

N1 - Funding Information: This work was supported in part by Grants-in-Aid for Young Scientists (B) and for Scientific Research (C) from the Japanese Ministry of Education, Culture, Sports, and Technology, and by Grants-in-Aid for Research on Psychiatric and Neurological Diseases and Mental Health, Comprehensive Research on Aging and Health, and Research on Pharmaceutical and Medical Safety from the Japanese Ministry of Health, Labour and Welfare.

PY - 2004/12/10

Y1 - 2004/12/10

N2 - Expression of dopamine receptors (DA-Rs) in astrocytes was examined in vitro and in vivo using primary cultured astrocytes and brain slices from rat basal ganglia. Astrocytes from basal ganglia expressed DA D1-, D3-, D4- and D5-receptors and D4-mediated signal transduction in response to DA, suggesting possible involvement of astrocytes in the pharmacological action of atypical antipsychotic drugs and in DA response in some neurological diseases.

AB - Expression of dopamine receptors (DA-Rs) in astrocytes was examined in vitro and in vivo using primary cultured astrocytes and brain slices from rat basal ganglia. Astrocytes from basal ganglia expressed DA D1-, D3-, D4- and D5-receptors and D4-mediated signal transduction in response to DA, suggesting possible involvement of astrocytes in the pharmacological action of atypical antipsychotic drugs and in DA response in some neurological diseases.

KW - Astrocyte

KW - Dopamine

KW - Dopamine antagonist

KW - Dopamine receptor

KW - cAMP responsive element binding protein

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Direct evidence for expression of dopamine receptors in astrocytes from basal ganglia

Abstract

Keywords

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