Dipole analysis in a case with tumor-related epilepsy

Harumi Yoshinaga, Tomoyuki Nakahori, Junri Hattori, Tomoyuki Akiyama, Eiji Oka, Susumu Tomita, Mizuho Aoi, Takasi Ohmoto, Keiichi Miyamoto

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Abstract

In order to evaluate the effectiveness of presurgical dipole analysis of interictal spikes as a non-invasive technique for the determination of epileptogenic area, we compared the results of this method with those of electrocorticography (ECoG) localization in the diagnosis of a patient with tumor-related epilepsy. A preoperative MRI revealed a temporal lobe tumor on the right side. The individual dipoles estimated from the interictal spikes were located mainly in the anterolateral region of the right temoral lobe, although some were located in the mesial side. The ECoG recorded frequent spikes in the anterolateral region of the right temporal lobe consistent with the location estimated by dipole analysis. After surgery, the patient suffered from residual seizures. Therefore, the residual epileptogenic area was examined by dipole analysis using a four-layered head model instead of the previous three-layered head model. As a result, the dipole analysis was able to pinpoint the epileptic focus in the area directly adjacent to the resected area, and in the mesial temporal lobe. In conclusion, EEG dipole analysis appears to hold promise as a non-invasive presurgical evaluation technique for locating epileptogenic areas as well as for postsurgical evaluation of residual epileptic focus. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)483-487
Number of pages5
JournalBrain and Development
Volume21
Issue number7
DOIs
Publication statusPublished - Oct 1 1999

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Keywords

  • Dipole analysis
  • Dysembryoplastic neuroepithelial tumor
  • Electrocorticography
  • Four-layered head model
  • Tumor epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

Cite this

Yoshinaga, H., Nakahori, T., Hattori, J., Akiyama, T., Oka, E., Tomita, S., Aoi, M., Ohmoto, T., & Miyamoto, K. (1999). Dipole analysis in a case with tumor-related epilepsy. Brain and Development, 21(7), 483-487. https://doi.org/10.1016/S0387-7604(99)00058-3