@article{584d49617a154460a7d4ee296a17812b,
title = "Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: Preparation of FXR and PPAR ligands",
abstract = "Novel, potent farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor α (PPARα) agonists were obtained by using a diphenylmethane skeleton as a substitute for a steroid skeleton.",
keywords = "Diphenylmethane, Drug design, FXR, Nuclear receptor ligands, PPAR",
author = "Masahiko Kainuma and Kasuga, {Jun ichi} and Shinnosuke Hosoda and Wakabayashi, {Ken ichi} and Aya Tanatani and Kazuo Nagasawa and Hiroyuki Miyachi and Makoto Makishima and Yuichi Hashimoto",
note = "Funding Information: The work described in this paper was partially supported by Grants-in-Aid for Scientific Research from The Ministry of Education, Culture, Sports, Science and Technology, Japan, and the Japan Society for the Promotion of Science. The authors are grateful to ASKA Pharm. Co. Ltd (Japan) for the generous supply of fabric acid. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",
year = "2006",
month = jun,
day = "15",
doi = "10.1016/j.bmcl.2006.03.075",
language = "English",
volume = "16",
pages = "3213--3218",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "12",
}