Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: Preparation of FXR and PPAR ligands

Masahiko Kainuma; Jun ichi Kasuga; Shinnosuke Hosoda; Ken ichi Wakabayashi; Aya Tanatani; Kazuo Nagasawa; Hiroyuki Miyachi; Makoto Makishima; Yuichi Hashimoto

doi:10.1016/j.bmcl.2006.03.075

Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: Preparation of FXR and PPAR ligands

Masahiko Kainuma, Jun ichi Kasuga, Shinnosuke Hosoda, Ken ichi Wakabayashi, Aya Tanatani, Kazuo Nagasawa, Hiroyuki Miyachi, Makoto Makishima, Yuichi Hashimoto

Faculty of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Novel, potent farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor α (PPARα) agonists were obtained by using a diphenylmethane skeleton as a substitute for a steroid skeleton.

Original language	English
Pages (from-to)	3213-3218
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	16
Issue number	12
DOIs	https://doi.org/10.1016/j.bmcl.2006.03.075
Publication status	Published - Jun 15 2006

Keywords

Diphenylmethane
Drug design
FXR
Nuclear receptor ligands
PPAR

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2006.03.075

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Diphenylmethane skeleton as a multi-template for nuclear receptor ligands : Preparation of FXR and PPAR ligands. / Kainuma, Masahiko; Kasuga, Jun ichi; Hosoda, Shinnosuke; Wakabayashi, Ken ichi; Tanatani, Aya; Nagasawa, Kazuo; Miyachi, Hiroyuki; Makishima, Makoto; Hashimoto, Yuichi.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 16, No. 12, 15.06.2006, p. 3213-3218.

Research output: Contribution to journal › Article › peer-review

Kainuma, Masahiko ; Kasuga, Jun ichi ; Hosoda, Shinnosuke ; Wakabayashi, Ken ichi ; Tanatani, Aya ; Nagasawa, Kazuo ; Miyachi, Hiroyuki ; Makishima, Makoto ; Hashimoto, Yuichi. / Diphenylmethane skeleton as a multi-template for nuclear receptor ligands : Preparation of FXR and PPAR ligands. In: Bioorganic and Medicinal Chemistry Letters. 2006 ; Vol. 16, No. 12. pp. 3213-3218.

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abstract = "Novel, potent farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor α (PPARα) agonists were obtained by using a diphenylmethane skeleton as a substitute for a steroid skeleton.",

keywords = "Diphenylmethane, Drug design, FXR, Nuclear receptor ligands, PPAR",

author = "Masahiko Kainuma and Kasuga, {Jun ichi} and Shinnosuke Hosoda and Wakabayashi, {Ken ichi} and Aya Tanatani and Kazuo Nagasawa and Hiroyuki Miyachi and Makoto Makishima and Yuichi Hashimoto",

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AU - Hosoda, Shinnosuke

AU - Wakabayashi, Ken ichi

AU - Tanatani, Aya

AU - Nagasawa, Kazuo

AU - Miyachi, Hiroyuki

AU - Makishima, Makoto

AU - Hashimoto, Yuichi

N1 - Funding Information: The work described in this paper was partially supported by Grants-in-Aid for Scientific Research from The Ministry of Education, Culture, Sports, Science and Technology, Japan, and the Japan Society for the Promotion of Science. The authors are grateful to ASKA Pharm. Co. Ltd (Japan) for the generous supply of fabric acid.

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KW - FXR

KW - Nuclear receptor ligands

KW - PPAR

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Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: Preparation of FXR and PPAR ligands

Abstract

Keywords

ASJC Scopus subject areas

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