Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: Preparation of FXR and PPAR ligands

Masahiko Kainuma, Jun ichi Kasuga, Shinnosuke Hosoda, Ken ichi Wakabayashi, Aya Tanatani, Kazuo Nagasawa, Hiroyuki Miyachi, Makoto Makishima, Yuichi Hashimoto

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Novel, potent farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor α (PPARα) agonists were obtained by using a diphenylmethane skeleton as a substitute for a steroid skeleton.

Original languageEnglish
Pages (from-to)3213-3218
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number12
DOIs
Publication statusPublished - Jun 15 2006

Keywords

  • Diphenylmethane
  • Drug design
  • FXR
  • Nuclear receptor ligands
  • PPAR

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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  • Cite this

    Kainuma, M., Kasuga, J. I., Hosoda, S., Wakabayashi, K. I., Tanatani, A., Nagasawa, K., Miyachi, H., Makishima, M., & Hashimoto, Y. (2006). Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: Preparation of FXR and PPAR ligands. Bioorganic and Medicinal Chemistry Letters, 16(12), 3213-3218. https://doi.org/10.1016/j.bmcl.2006.03.075