Digital radiographic quantification of myocardial blood flow around a transmyocardial laser channel in rabbit hearts

Osami Honjo, Kozo Ishino, Takeshi Matsumoto, Shu Yamamoto, Tomohiro Asai, Takushi Kohmoto, Fumihiko Kajiya, Shunji Sano

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: A mechanism underlying the benefits of transmyocardial laser revascularization (TMLR) has been presumed to be improvement in perfusion. We evaluated myocardial blood flow around a laser channel using digital radiography combined with a 3H-labeled desmethylimipramine ([3H]DMI) deposition. Methods and Results: A laser channel was created in the left ventricular wall using a YAG-laser in 6 non-ischemic rabbit hearts. After 8 weeks, [3H]DMI(1.11 MBq) was injected into the left atrium and the TMLR-treated myocardium was sectioned. Another 6 hearts were examined as controls. We measured [3H]DMI density in arbitrary units with digital radiography in the channel remnant, the surrounding area and a remote area. Flow distribution was quantified by the coefficient of variation of flows (CV). The surrounding area had the highest density (p

Original languageEnglish
Pages (from-to)488-492
Number of pages5
JournalCirculation Journal
Volume69
Issue number4
DOIs
Publication statusPublished - Apr 2005

Fingerprint

Transmyocardial Laser Revascularization
Radiographic Image Enhancement
Lasers
Rabbits
Desipramine
Solid-State Lasers
Heart Atria
Myocardium
Perfusion

Keywords

  • Angiogenesis
  • Digital radiography
  • Microcirculation
  • Perfusion
  • Transmyocardial laser revascularization

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Honjo, O., Ishino, K., Matsumoto, T., Yamamoto, S., Asai, T., Kohmoto, T., ... Sano, S. (2005). Digital radiographic quantification of myocardial blood flow around a transmyocardial laser channel in rabbit hearts. Circulation Journal, 69(4), 488-492. https://doi.org/10.1253/circj.69.488

Digital radiographic quantification of myocardial blood flow around a transmyocardial laser channel in rabbit hearts. / Honjo, Osami; Ishino, Kozo; Matsumoto, Takeshi; Yamamoto, Shu; Asai, Tomohiro; Kohmoto, Takushi; Kajiya, Fumihiko; Sano, Shunji.

In: Circulation Journal, Vol. 69, No. 4, 04.2005, p. 488-492.

Research output: Contribution to journalArticle

Honjo, O, Ishino, K, Matsumoto, T, Yamamoto, S, Asai, T, Kohmoto, T, Kajiya, F & Sano, S 2005, 'Digital radiographic quantification of myocardial blood flow around a transmyocardial laser channel in rabbit hearts', Circulation Journal, vol. 69, no. 4, pp. 488-492. https://doi.org/10.1253/circj.69.488
Honjo, Osami ; Ishino, Kozo ; Matsumoto, Takeshi ; Yamamoto, Shu ; Asai, Tomohiro ; Kohmoto, Takushi ; Kajiya, Fumihiko ; Sano, Shunji. / Digital radiographic quantification of myocardial blood flow around a transmyocardial laser channel in rabbit hearts. In: Circulation Journal. 2005 ; Vol. 69, No. 4. pp. 488-492.
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