Diffuse submucosal cysts of the stomach associated with gastric cancer: Contribution of Helicobacter pyroli infections

Atsunori Nakao, Shizo Sato, Akira Nabeyama, Kenichi Sakagami, Hiroshi Isozaki, Noriaki Tanaka

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Diffuse submucosal cysts (DSCs) in the stomach are often associated with gastric cancer and a high occurrence of multiple gastric cancers. We studied the clinicopathological features of four early gastric cancer patients with DSCs in the submucosal layer of the stomach. All patients had early gastric cancers with gastritis and erosion in the gastric mucosa, and were positive for Helicobacter pyroli (H. pyroli). Based on a review of the reported cases, we found that a very high proportion (>94%) of DSCs are associated with infection by H. pyroli. Although DSCs have previously been considered to be paracancerous lesions of gastric cancer, we speculate that DSCs might be post-inflammatory changes following infection by H. pyroli, which may result in the high incidence of gastric cancer development.

Original languageEnglish
Pages (from-to)3711-3715
Number of pages5
JournalAnticancer Research
Volume21
Issue number5
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Helicobacter Infections
Stomach Neoplasms
Cysts
Stomach
Helicobacter
Gastritis
Gastric Mucosa
Incidence

Keywords

  • Diffuse submucosal cysts
  • Gastric cancer
  • Helicobacter pyroli

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Diffuse submucosal cysts of the stomach associated with gastric cancer : Contribution of Helicobacter pyroli infections. / Nakao, Atsunori; Sato, Shizo; Nabeyama, Akira; Sakagami, Kenichi; Isozaki, Hiroshi; Tanaka, Noriaki.

In: Anticancer Research, Vol. 21, No. 5, 2001, p. 3711-3715.

Research output: Contribution to journalArticle

Nakao, A, Sato, S, Nabeyama, A, Sakagami, K, Isozaki, H & Tanaka, N 2001, 'Diffuse submucosal cysts of the stomach associated with gastric cancer: Contribution of Helicobacter pyroli infections', Anticancer Research, vol. 21, no. 5, pp. 3711-3715.
Nakao, Atsunori ; Sato, Shizo ; Nabeyama, Akira ; Sakagami, Kenichi ; Isozaki, Hiroshi ; Tanaka, Noriaki. / Diffuse submucosal cysts of the stomach associated with gastric cancer : Contribution of Helicobacter pyroli infections. In: Anticancer Research. 2001 ; Vol. 21, No. 5. pp. 3711-3715.
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