Diffuse submucosal cysts of the stomach associated with gastric cancer: Contribution of Helicobacter pyroli infections

Atsunori Nakao, Shizo Sato, Akira Nabeyama, Kenichi Sakagami, Hiroshi Isozaki, Noriaki Tanaka

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4 Citations (Scopus)


Diffuse submucosal cysts (DSCs) in the stomach are often associated with gastric cancer and a high occurrence of multiple gastric cancers. We studied the clinicopathological features of four early gastric cancer patients with DSCs in the submucosal layer of the stomach. All patients had early gastric cancers with gastritis and erosion in the gastric mucosa, and were positive for Helicobacter pyroli (H. pyroli). Based on a review of the reported cases, we found that a very high proportion (>94%) of DSCs are associated with infection by H. pyroli. Although DSCs have previously been considered to be paracancerous lesions of gastric cancer, we speculate that DSCs might be post-inflammatory changes following infection by H. pyroli, which may result in the high incidence of gastric cancer development.

Original languageEnglish
Pages (from-to)3711-3715
Number of pages5
JournalAnticancer research
Issue number5
Publication statusPublished - Dec 1 2001



  • Diffuse submucosal cysts
  • Gastric cancer
  • Helicobacter pyroli

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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