Diffuse parenchymal pulmonary amyloidosis showing an objective response to bortezomib-based chemotherapy

Hisao Higo, Keiichi Fujiwara, Hiromi Watanabe, Go Makimoto, Nobuhisa Kameyama, Mizuho Matsushita, Kammei Rai, Ken Sato, Tomoko Inomata, Kazutaka Sunami, Takuo Shibayama

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3 Citations (Scopus)

Abstract

A 77-year-old woman was admitted because of bilateral hand numbness and dyspnea on exertion. Her serum IgG was increased, and a bone marrow aspiration analysis supported a diagnosis of multiple myeloma. Additionally, computed tomography scans of the chest showed bilateral ground glass attenuations, linear opacities, and consolidations. Transbronchial lung biopsy revealed Congo Red-positive amorphous eosinophilic deposits. She was therefore diagnosed with diffuse parenchymal pulmonary amyloidosis accompanied by multiple myeloma. Following combination chemotherapy including bortezomib, her serum monoclonal protein levels were normalized, and pulmonary function and oxygenation improved.

Original languageEnglish
Pages (from-to)1809-1812
Number of pages4
JournalInternal Medicine
Volume53
Issue number16
DOIs
Publication statusPublished - Jan 1 2014

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Keywords

  • Bortezomib
  • Diffuse parenchymal pulmonary amyloidosis
  • Ground glass attenuation
  • Multiple myeloma

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Higo, H., Fujiwara, K., Watanabe, H., Makimoto, G., Kameyama, N., Matsushita, M., Rai, K., Sato, K., Inomata, T., Sunami, K., & Shibayama, T. (2014). Diffuse parenchymal pulmonary amyloidosis showing an objective response to bortezomib-based chemotherapy. Internal Medicine, 53(16), 1809-1812. https://doi.org/10.2169/internalmedicine.53.1728