Diffuse parenchymal pulmonary amyloidosis showing an objective response to bortezomib-based chemotherapy

Hisao Higo; Keiichi Fujiwara; Hiromi Watanabe; Go Makimoto; Nobuhisa Kameyama; Mizuho Matsushita; Kanmei Rai; Ken Sato; Tomoko Inomata; Kazutaka Sunami; Takuo Shibayama

doi:10.2169/internalmedicine.53.1728

Diffuse parenchymal pulmonary amyloidosis showing an objective response to bortezomib-based chemotherapy

Hisao Higo, Keiichi Fujiwara, Hiromi Watanabe, Go Makimoto, Nobuhisa Kameyama, Mizuho Matsushita, Kanmei Rai, Ken Sato, Tomoko Inomata, Kazutaka Sunami, Takuo Shibayama

University Hospital

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

A 77-year-old woman was admitted because of bilateral hand numbness and dyspnea on exertion. Her serum IgG was increased, and a bone marrow aspiration analysis supported a diagnosis of multiple myeloma. Additionally, computed tomography scans of the chest showed bilateral ground glass attenuations, linear opacities, and consolidations. Transbronchial lung biopsy revealed Congo Red-positive amorphous eosinophilic deposits. She was therefore diagnosed with diffuse parenchymal pulmonary amyloidosis accompanied by multiple myeloma. Following combination chemotherapy including bortezomib, her serum monoclonal protein levels were normalized, and pulmonary function and oxygenation improved.

Original language	English
Pages (from-to)	1809-1812
Number of pages	4
Journal	Internal Medicine
Volume	53
Issue number	16
DOIs	https://doi.org/10.2169/internalmedicine.53.1728
Publication status	Published - 2014

Keywords

Bortezomib
Diffuse parenchymal pulmonary amyloidosis
Ground glass attenuation
Multiple myeloma

ASJC Scopus subject areas

Internal Medicine

Access to Document

10.2169/internalmedicine.53.1728

Cite this

@article{cf2f801a1cb34486babe3e6c63bb7415,

title = "Diffuse parenchymal pulmonary amyloidosis showing an objective response to bortezomib-based chemotherapy",

abstract = "A 77-year-old woman was admitted because of bilateral hand numbness and dyspnea on exertion. Her serum IgG was increased, and a bone marrow aspiration analysis supported a diagnosis of multiple myeloma. Additionally, computed tomography scans of the chest showed bilateral ground glass attenuations, linear opacities, and consolidations. Transbronchial lung biopsy revealed Congo Red-positive amorphous eosinophilic deposits. She was therefore diagnosed with diffuse parenchymal pulmonary amyloidosis accompanied by multiple myeloma. Following combination chemotherapy including bortezomib, her serum monoclonal protein levels were normalized, and pulmonary function and oxygenation improved.",

keywords = "Bortezomib, Diffuse parenchymal pulmonary amyloidosis, Ground glass attenuation, Multiple myeloma",

author = "Hisao Higo and Keiichi Fujiwara and Hiromi Watanabe and Go Makimoto and Nobuhisa Kameyama and Mizuho Matsushita and Kanmei Rai and Ken Sato and Tomoko Inomata and Kazutaka Sunami and Takuo Shibayama",

note = "Publisher Copyright: {\textcopyright} 2014 The Japanese Society of Internal Medicine.",

year = "2014",

doi = "10.2169/internalmedicine.53.1728",

language = "English",

volume = "53",

pages = "1809--1812",

journal = "Internal Medicine",

issn = "0918-2918",

publisher = "Japanese Society of Internal Medicine",

number = "16",

}

TY - JOUR

T1 - Diffuse parenchymal pulmonary amyloidosis showing an objective response to bortezomib-based chemotherapy

AU - Higo, Hisao

AU - Fujiwara, Keiichi

AU - Watanabe, Hiromi

AU - Makimoto, Go

AU - Kameyama, Nobuhisa

AU - Matsushita, Mizuho

AU - Rai, Kanmei

AU - Sato, Ken

AU - Inomata, Tomoko

AU - Sunami, Kazutaka

AU - Shibayama, Takuo

PY - 2014

Y1 - 2014

N2 - A 77-year-old woman was admitted because of bilateral hand numbness and dyspnea on exertion. Her serum IgG was increased, and a bone marrow aspiration analysis supported a diagnosis of multiple myeloma. Additionally, computed tomography scans of the chest showed bilateral ground glass attenuations, linear opacities, and consolidations. Transbronchial lung biopsy revealed Congo Red-positive amorphous eosinophilic deposits. She was therefore diagnosed with diffuse parenchymal pulmonary amyloidosis accompanied by multiple myeloma. Following combination chemotherapy including bortezomib, her serum monoclonal protein levels were normalized, and pulmonary function and oxygenation improved.

AB - A 77-year-old woman was admitted because of bilateral hand numbness and dyspnea on exertion. Her serum IgG was increased, and a bone marrow aspiration analysis supported a diagnosis of multiple myeloma. Additionally, computed tomography scans of the chest showed bilateral ground glass attenuations, linear opacities, and consolidations. Transbronchial lung biopsy revealed Congo Red-positive amorphous eosinophilic deposits. She was therefore diagnosed with diffuse parenchymal pulmonary amyloidosis accompanied by multiple myeloma. Following combination chemotherapy including bortezomib, her serum monoclonal protein levels were normalized, and pulmonary function and oxygenation improved.

KW - Bortezomib

KW - Diffuse parenchymal pulmonary amyloidosis

KW - Ground glass attenuation

KW - Multiple myeloma

UR - http://www.scopus.com/inward/record.url?scp=84906738406&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84906738406&partnerID=8YFLogxK

U2 - 10.2169/internalmedicine.53.1728

DO - 10.2169/internalmedicine.53.1728

M3 - Article

C2 - 25130116

AN - SCOPUS:84906738406

SN - 0918-2918

VL - 53

SP - 1809

EP - 1812

JO - Internal Medicine

JF - Internal Medicine

IS - 16

ER -

Diffuse parenchymal pulmonary amyloidosis showing an objective response to bortezomib-based chemotherapy

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this