Diffuse neurofibrillary tangles with calcification (a form of dementia): X-ray spectrometric evidence of lead accumulation in calcified regions

Takashi Haraguchi, Hideki Ishizu, Kensuke Kawai, Yasuyuki Tanabe, Kenzo Uehira, Yasushi Takehisa, Seishi Terada, Kuniaki Tsuchiya, Kenji Ikeda, Shigetoshi Kuroda

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14 Citations (Scopus)

Abstract

Diffuse neurofibrillary tangles with calcification (DNTC) is a form of slowly progressive dementia in which no senile plaques are observed. The calcification is one of the most characteristic features of DNTC. We examined the elemental content of certain mineral deposits (lead, magnesium, phosphorus, calcium, iron, copper and zinc) in the calcified and non-calcified regions of eight cases of DNTC, five cases of Alzheimer's disease (AD) and in eight non-demented elderly controls. The study was performed using a combination of scanning electron microscopy and X-ray spectrometry on 10% formalin-fixed brain tissue. A marked abundance of calcium and phosphorus was observed in the calcified regions of DNTC and non-DNTC brains. Although no lead was observed in the non-calcified regions of DNTC and in non-DNTC brains, traces of lead were detected exclusively in the calcified regions of DNTC brains. The implications and possible significance of the lead accumulation in DNTC brains are discussed.

Original languageEnglish
Pages (from-to)1257-1260
Number of pages4
JournalNeuroReport
Volume12
Issue number6
DOIs
Publication statusPublished - May 8 2001

Keywords

  • Calcification
  • Dementia
  • Diffuse neurofibrillary tangles with calcification (DNTC)
  • Lead
  • X-ray spectrometry

ASJC Scopus subject areas

  • Neuroscience(all)

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    Haraguchi, T., Ishizu, H., Kawai, K., Tanabe, Y., Uehira, K., Takehisa, Y., Terada, S., Tsuchiya, K., Ikeda, K., & Kuroda, S. (2001). Diffuse neurofibrillary tangles with calcification (a form of dementia): X-ray spectrometric evidence of lead accumulation in calcified regions. NeuroReport, 12(6), 1257-1260. https://doi.org/10.1097/00001756-200105080-00040