Abstract
Diffuse neurofibrillary tangles with calcification (DNTC) is a form of slowly progressive dementia in which no senile plaques are observed. The calcification is one of the most characteristic features of DNTC. We examined the elemental content of certain mineral deposits (lead, magnesium, phosphorus, calcium, iron, copper and zinc) in the calcified and non-calcified regions of eight cases of DNTC, five cases of Alzheimer's disease (AD) and in eight non-demented elderly controls. The study was performed using a combination of scanning electron microscopy and X-ray spectrometry on 10% formalin-fixed brain tissue. A marked abundance of calcium and phosphorus was observed in the calcified regions of DNTC and non-DNTC brains. Although no lead was observed in the non-calcified regions of DNTC and in non-DNTC brains, traces of lead were detected exclusively in the calcified regions of DNTC brains. The implications and possible significance of the lead accumulation in DNTC brains are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 1257-1260 |
| Number of pages | 4 |
| Journal | NeuroReport |
| Volume | 12 |
| Issue number | 6 |
| Publication status | Published - May 8 2001 |
Fingerprint
Keywords
- Calcification
- Dementia
- Diffuse neurofibrillary tangles with calcification (DNTC)
- Lead
- X-ray spectrometry
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Diffuse neurofibrillary tangles with calcification (a form of dementia) : X-ray spectrometric evidence of lead accumulation in calcified regions. / Haraguchi, Takashi; Ishizu, Hideki; Kawai, Kensuke; Tanabe, Yasuyuki; Uehira, Kenzo; Takehisa, Yasushi; Terada, Seishi; Tsuchiya, Kuniaki; Ikeda, Kenji; Kuroda, Shigetoshi.
In: NeuroReport, Vol. 12, No. 6, 08.05.2001, p. 1257-1260.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Diffuse neurofibrillary tangles with calcification (a form of dementia)
T2 - X-ray spectrometric evidence of lead accumulation in calcified regions
AU - Haraguchi, Takashi
AU - Ishizu, Hideki
AU - Kawai, Kensuke
AU - Tanabe, Yasuyuki
AU - Uehira, Kenzo
AU - Takehisa, Yasushi
AU - Terada, Seishi
AU - Tsuchiya, Kuniaki
AU - Ikeda, Kenji
AU - Kuroda, Shigetoshi
PY - 2001/5/8
Y1 - 2001/5/8
N2 - Diffuse neurofibrillary tangles with calcification (DNTC) is a form of slowly progressive dementia in which no senile plaques are observed. The calcification is one of the most characteristic features of DNTC. We examined the elemental content of certain mineral deposits (lead, magnesium, phosphorus, calcium, iron, copper and zinc) in the calcified and non-calcified regions of eight cases of DNTC, five cases of Alzheimer's disease (AD) and in eight non-demented elderly controls. The study was performed using a combination of scanning electron microscopy and X-ray spectrometry on 10% formalin-fixed brain tissue. A marked abundance of calcium and phosphorus was observed in the calcified regions of DNTC and non-DNTC brains. Although no lead was observed in the non-calcified regions of DNTC and in non-DNTC brains, traces of lead were detected exclusively in the calcified regions of DNTC brains. The implications and possible significance of the lead accumulation in DNTC brains are discussed.
AB - Diffuse neurofibrillary tangles with calcification (DNTC) is a form of slowly progressive dementia in which no senile plaques are observed. The calcification is one of the most characteristic features of DNTC. We examined the elemental content of certain mineral deposits (lead, magnesium, phosphorus, calcium, iron, copper and zinc) in the calcified and non-calcified regions of eight cases of DNTC, five cases of Alzheimer's disease (AD) and in eight non-demented elderly controls. The study was performed using a combination of scanning electron microscopy and X-ray spectrometry on 10% formalin-fixed brain tissue. A marked abundance of calcium and phosphorus was observed in the calcified regions of DNTC and non-DNTC brains. Although no lead was observed in the non-calcified regions of DNTC and in non-DNTC brains, traces of lead were detected exclusively in the calcified regions of DNTC brains. The implications and possible significance of the lead accumulation in DNTC brains are discussed.
KW - Calcification
KW - Dementia
KW - Diffuse neurofibrillary tangles with calcification (DNTC)
KW - Lead
KW - X-ray spectrometry
UR - http://www.scopus.com/inward/record.url?scp=0035826748&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035826748&partnerID=8YFLogxK
M3 - Article
VL - 12
SP - 1257
EP - 1260
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 6
ER -