Diffuse intestinal ganglioneuromatosis showing multiple large bowel ulcers in a patient with neurofibromatosis type 1

Masaya Iwamuro; Rika Omote; Takehiro Tanaka; Naruhiko Sunada; Takahiro Nada; Yoshitaka Kondo; Soichiro Nose; Mitsuhiko Kawaguchi; Fumio Otsuka; Hiroyuki Okada

doi:10.2169/internalmedicine.8671-16

Diffuse intestinal ganglioneuromatosis showing multiple large bowel ulcers in a patient with neurofibromatosis type 1

Masaya Iwamuro, Rika Omote, Takehiro Tanaka, Naruhiko Sunada, Takahiro Nada, Yoshitaka Kondo, Soichiro Nose, Mitsuhiko Kawaguchi, Fumio Otsuka, Hiroyuki Okada

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

A 67-year-old Japanese man with neurofibromatosis type 1 underwent right hemicolectomy owing to abscess formation around the cecum. A pathological analysis revealed diffuse intestinal ganglioneuromatosis in the cecum and colon. Colonoscopy performed eight months after hemicolectomy revealed multiple ulcers throughout the colon and rectum. The colorectal ulcers failed to respond to conservative treatment and ultimately required surgical resection. Diffuse ganglioneuromatosis was observed again in the resected specimen. This report illustrates a rare manifestation of diffuse intestinal ganglioneuromatosis in a patient with neurofibromatosis type 1.

Original language	English
Pages (from-to)	3287-3291
Number of pages	5
Journal	Internal Medicine
Volume	56
Issue number	24
DOIs	https://doi.org/10.2169/internalmedicine.8671-16
Publication status	Published - 2017

Keywords

Colorectal ulcers
Diffuse intestinal ganglioneuromatosis
Neurofibromatosis type 1

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.8671-16

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title = "Diffuse intestinal ganglioneuromatosis showing multiple large bowel ulcers in a patient with neurofibromatosis type 1",

abstract = "A 67-year-old Japanese man with neurofibromatosis type 1 underwent right hemicolectomy owing to abscess formation around the cecum. A pathological analysis revealed diffuse intestinal ganglioneuromatosis in the cecum and colon. Colonoscopy performed eight months after hemicolectomy revealed multiple ulcers throughout the colon and rectum. The colorectal ulcers failed to respond to conservative treatment and ultimately required surgical resection. Diffuse ganglioneuromatosis was observed again in the resected specimen. This report illustrates a rare manifestation of diffuse intestinal ganglioneuromatosis in a patient with neurofibromatosis type 1.",

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author = "Masaya Iwamuro and Rika Omote and Takehiro Tanaka and Naruhiko Sunada and Takahiro Nada and Yoshitaka Kondo and Soichiro Nose and Mitsuhiko Kawaguchi and Fumio Otsuka and Hiroyuki Okada",

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T1 - Diffuse intestinal ganglioneuromatosis showing multiple large bowel ulcers in a patient with neurofibromatosis type 1

AU - Iwamuro, Masaya

AU - Omote, Rika

AU - Tanaka, Takehiro

AU - Sunada, Naruhiko

AU - Nada, Takahiro

AU - Kondo, Yoshitaka

AU - Nose, Soichiro

AU - Kawaguchi, Mitsuhiko

AU - Otsuka, Fumio

AU - Okada, Hiroyuki

PY - 2017

Y1 - 2017

N2 - A 67-year-old Japanese man with neurofibromatosis type 1 underwent right hemicolectomy owing to abscess formation around the cecum. A pathological analysis revealed diffuse intestinal ganglioneuromatosis in the cecum and colon. Colonoscopy performed eight months after hemicolectomy revealed multiple ulcers throughout the colon and rectum. The colorectal ulcers failed to respond to conservative treatment and ultimately required surgical resection. Diffuse ganglioneuromatosis was observed again in the resected specimen. This report illustrates a rare manifestation of diffuse intestinal ganglioneuromatosis in a patient with neurofibromatosis type 1.

AB - A 67-year-old Japanese man with neurofibromatosis type 1 underwent right hemicolectomy owing to abscess formation around the cecum. A pathological analysis revealed diffuse intestinal ganglioneuromatosis in the cecum and colon. Colonoscopy performed eight months after hemicolectomy revealed multiple ulcers throughout the colon and rectum. The colorectal ulcers failed to respond to conservative treatment and ultimately required surgical resection. Diffuse ganglioneuromatosis was observed again in the resected specimen. This report illustrates a rare manifestation of diffuse intestinal ganglioneuromatosis in a patient with neurofibromatosis type 1.

KW - Colorectal ulcers

KW - Diffuse intestinal ganglioneuromatosis

KW - Neurofibromatosis type 1

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JO - Internal Medicine

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Diffuse intestinal ganglioneuromatosis showing multiple large bowel ulcers in a patient with neurofibromatosis type 1

Abstract

Keywords

ASJC Scopus subject areas

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