Diffuse intestinal ganglioneuromatosis showing multiple large bowel ulcers in a patient with neurofibromatosis type 1

Masaya Iwamuro, Rika Omote, Takehiro Tanaka, Naruhiko Sunada, Takahiro Nada, Yoshitaka Kondo, Soichiro Nose, Mitsuhiko Kawaguchi, Fumio Otsuka, Hiroyuki Okada

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A 67-year-old Japanese man with neurofibromatosis type 1 underwent right hemicolectomy owing to abscess formation around the cecum. A pathological analysis revealed diffuse intestinal ganglioneuromatosis in the cecum and colon. Colonoscopy performed eight months after hemicolectomy revealed multiple ulcers throughout the colon and rectum. The colorectal ulcers failed to respond to conservative treatment and ultimately required surgical resection. Diffuse ganglioneuromatosis was observed again in the resected specimen. This report illustrates a rare manifestation of diffuse intestinal ganglioneuromatosis in a patient with neurofibromatosis type 1.

Original languageEnglish
Pages (from-to)3287-3291
Number of pages5
JournalInternal Medicine
Volume56
Issue number24
DOIs
Publication statusPublished - Jan 1 2017

Fingerprint

Neurofibromatosis 1
Cecum
Ulcer
Colon
Colonoscopy
Rectum
Abscess
Conservative Treatment

Keywords

  • Colorectal ulcers
  • Diffuse intestinal ganglioneuromatosis
  • Neurofibromatosis type 1

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Diffuse intestinal ganglioneuromatosis showing multiple large bowel ulcers in a patient with neurofibromatosis type 1. / Iwamuro, Masaya; Omote, Rika; Tanaka, Takehiro; Sunada, Naruhiko; Nada, Takahiro; Kondo, Yoshitaka; Nose, Soichiro; Kawaguchi, Mitsuhiko; Otsuka, Fumio; Okada, Hiroyuki.

In: Internal Medicine, Vol. 56, No. 24, 01.01.2017, p. 3287-3291.

Research output: Contribution to journalArticle

@article{d604df24ccd141daaf821d753663be82,
title = "Diffuse intestinal ganglioneuromatosis showing multiple large bowel ulcers in a patient with neurofibromatosis type 1",
abstract = "A 67-year-old Japanese man with neurofibromatosis type 1 underwent right hemicolectomy owing to abscess formation around the cecum. A pathological analysis revealed diffuse intestinal ganglioneuromatosis in the cecum and colon. Colonoscopy performed eight months after hemicolectomy revealed multiple ulcers throughout the colon and rectum. The colorectal ulcers failed to respond to conservative treatment and ultimately required surgical resection. Diffuse ganglioneuromatosis was observed again in the resected specimen. This report illustrates a rare manifestation of diffuse intestinal ganglioneuromatosis in a patient with neurofibromatosis type 1.",
keywords = "Colorectal ulcers, Diffuse intestinal ganglioneuromatosis, Neurofibromatosis type 1",
author = "Masaya Iwamuro and Rika Omote and Takehiro Tanaka and Naruhiko Sunada and Takahiro Nada and Yoshitaka Kondo and Soichiro Nose and Mitsuhiko Kawaguchi and Fumio Otsuka and Hiroyuki Okada",
year = "2017",
month = "1",
day = "1",
doi = "10.2169/internalmedicine.8671-16",
language = "English",
volume = "56",
pages = "3287--3291",
journal = "Internal Medicine",
issn = "0918-2918",
publisher = "Japanese Society of Internal Medicine",
number = "24",

}

TY - JOUR

T1 - Diffuse intestinal ganglioneuromatosis showing multiple large bowel ulcers in a patient with neurofibromatosis type 1

AU - Iwamuro, Masaya

AU - Omote, Rika

AU - Tanaka, Takehiro

AU - Sunada, Naruhiko

AU - Nada, Takahiro

AU - Kondo, Yoshitaka

AU - Nose, Soichiro

AU - Kawaguchi, Mitsuhiko

AU - Otsuka, Fumio

AU - Okada, Hiroyuki

PY - 2017/1/1

Y1 - 2017/1/1

N2 - A 67-year-old Japanese man with neurofibromatosis type 1 underwent right hemicolectomy owing to abscess formation around the cecum. A pathological analysis revealed diffuse intestinal ganglioneuromatosis in the cecum and colon. Colonoscopy performed eight months after hemicolectomy revealed multiple ulcers throughout the colon and rectum. The colorectal ulcers failed to respond to conservative treatment and ultimately required surgical resection. Diffuse ganglioneuromatosis was observed again in the resected specimen. This report illustrates a rare manifestation of diffuse intestinal ganglioneuromatosis in a patient with neurofibromatosis type 1.

AB - A 67-year-old Japanese man with neurofibromatosis type 1 underwent right hemicolectomy owing to abscess formation around the cecum. A pathological analysis revealed diffuse intestinal ganglioneuromatosis in the cecum and colon. Colonoscopy performed eight months after hemicolectomy revealed multiple ulcers throughout the colon and rectum. The colorectal ulcers failed to respond to conservative treatment and ultimately required surgical resection. Diffuse ganglioneuromatosis was observed again in the resected specimen. This report illustrates a rare manifestation of diffuse intestinal ganglioneuromatosis in a patient with neurofibromatosis type 1.

KW - Colorectal ulcers

KW - Diffuse intestinal ganglioneuromatosis

KW - Neurofibromatosis type 1

UR - http://www.scopus.com/inward/record.url?scp=85040072970&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85040072970&partnerID=8YFLogxK

U2 - 10.2169/internalmedicine.8671-16

DO - 10.2169/internalmedicine.8671-16

M3 - Article

C2 - 29021449

AN - SCOPUS:85040072970

VL - 56

SP - 3287

EP - 3291

JO - Internal Medicine

JF - Internal Medicine

SN - 0918-2918

IS - 24

ER -