Differentiation of thyroid nodules using TI-201 scintigraphy quantitative analysis and fine-needle aspiration biopsy

Yasuhiro Yamamoto, Yoshihiro Okumura, Shuhei Sato, Kumi Maki, Takashi Mukai, Hirofumi Mifune, Shiro Akaki, Yoshihiro Takeda, Susumu Kanazawa, Yoshio Hiraki

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We studied the differentiation of thyroid nodules using fine-needle aspiration biopsy (FNA) and Tl-201 scintigraphy quantitative analysis. One-hundred and thirty-one thyroid nodules were examined: 83 follicular lesions (58 benign and 25 malignant lesions) and 48 non-follicular lesions (8 benign and 40 malignant lesions). During Tl-201 scintigraphy examinations, an early and a delayed image were acquired 10 and 120 min after an intravenous injection, respectively. The T/N ratio (counts of nodular lesion/counts of contralateral normal thyroid tissue) of each image was calculated quantitatively. We assessed the ability of the Tl-201 scintigraphy and of the FNA analysis to differentiate benign and malignant lesions and determined the cut-off levels for the assays. For the follicular lesions, the area under the ROC (Receiver Operating Characteristic) curve (Az) for the Tl-201 scintigraphy data was greater than that for the FNA data. For the non-follicular lesions, the Az for the FNA data was greater than that for the Tl-201 scintigraphy data. We set cut-off levels at 1.370 for follicular lesions, and 1.070 for non-follicular lesions. The sensitivity and specificity were 76% and 82.7% for follicular lesions, and 90% and 87.5% for non-follicular lesions, respectively. The overall accuracy of the analysis was 84.0%.

Original languageEnglish
Pages (from-to)75-83
Number of pages9
JournalActa Medica Okayama
Volume58
Issue number2
Publication statusPublished - Apr 2004

Fingerprint

Thyroid Nodule
Biopsy
Fine Needle Biopsy
Radionuclide Imaging
Needles
Chemical analysis
Assays
ROC Curve
Intravenous Injections
Tissue
Thyroid Gland
Sensitivity and Specificity

Keywords

  • Fine-needle aspiration biopsy (FNA)
  • Thyroid nodules
  • Tl-201 scintigraphy

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Yamamoto, Y., Okumura, Y., Sato, S., Maki, K., Mukai, T., Mifune, H., ... Hiraki, Y. (2004). Differentiation of thyroid nodules using TI-201 scintigraphy quantitative analysis and fine-needle aspiration biopsy. Acta Medica Okayama, 58(2), 75-83.

Differentiation of thyroid nodules using TI-201 scintigraphy quantitative analysis and fine-needle aspiration biopsy. / Yamamoto, Yasuhiro; Okumura, Yoshihiro; Sato, Shuhei; Maki, Kumi; Mukai, Takashi; Mifune, Hirofumi; Akaki, Shiro; Takeda, Yoshihiro; Kanazawa, Susumu; Hiraki, Yoshio.

In: Acta Medica Okayama, Vol. 58, No. 2, 04.2004, p. 75-83.

Research output: Contribution to journalArticle

Yamamoto, Y, Okumura, Y, Sato, S, Maki, K, Mukai, T, Mifune, H, Akaki, S, Takeda, Y, Kanazawa, S & Hiraki, Y 2004, 'Differentiation of thyroid nodules using TI-201 scintigraphy quantitative analysis and fine-needle aspiration biopsy', Acta Medica Okayama, vol. 58, no. 2, pp. 75-83.
Yamamoto, Yasuhiro ; Okumura, Yoshihiro ; Sato, Shuhei ; Maki, Kumi ; Mukai, Takashi ; Mifune, Hirofumi ; Akaki, Shiro ; Takeda, Yoshihiro ; Kanazawa, Susumu ; Hiraki, Yoshio. / Differentiation of thyroid nodules using TI-201 scintigraphy quantitative analysis and fine-needle aspiration biopsy. In: Acta Medica Okayama. 2004 ; Vol. 58, No. 2. pp. 75-83.
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