Differentiation of thyroid nodules using TI-201 scintigraphy quantitative analysis and fine-needle aspiration biopsy

Yasuhiro Yamamoto, Yoshihiro Okumura, Shuhei Sato, Kumi Maki, Takashi Mukai, Hirofumi Mifune, Shiro Akaki, Yoshihiro Takeda, Susumu Kanazawa, Yoshio Hiraki

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2 Citations (Scopus)


We studied the differentiation of thyroid nodules using fine-needle aspiration biopsy (FNA) and Tl-201 scintigraphy quantitative analysis. One-hundred and thirty-one thyroid nodules were examined: 83 follicular lesions (58 benign and 25 malignant lesions) and 48 non-follicular lesions (8 benign and 40 malignant lesions). During Tl-201 scintigraphy examinations, an early and a delayed image were acquired 10 and 120 min after an intravenous injection, respectively. The T/N ratio (counts of nodular lesion/counts of contralateral normal thyroid tissue) of each image was calculated quantitatively. We assessed the ability of the Tl-201 scintigraphy and of the FNA analysis to differentiate benign and malignant lesions and determined the cut-off levels for the assays. For the follicular lesions, the area under the ROC (Receiver Operating Characteristic) curve (Az) for the Tl-201 scintigraphy data was greater than that for the FNA data. For the non-follicular lesions, the Az for the FNA data was greater than that for the Tl-201 scintigraphy data. We set cut-off levels at 1.370 for follicular lesions, and 1.070 for non-follicular lesions. The sensitivity and specificity were 76% and 82.7% for follicular lesions, and 90% and 87.5% for non-follicular lesions, respectively. The overall accuracy of the analysis was 84.0%.

Original languageEnglish
Pages (from-to)75-83
Number of pages9
JournalActa medica Okayama
Issue number2
Publication statusPublished - Apr 2004


  • Fine-needle aspiration biopsy (FNA)
  • Thyroid nodules
  • Tl-201 scintigraphy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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