Differentiation of PA from early PSP with different patterns of symptoms and CBF reduction

Tomoko Kurata, Takeshi Hayashi, Tetsuro Murakami, Kazunori Miyazaki, Nobutoshi Morimoto, Yasuyuki Ohta, Yasushi Takehisa, Makiko Nagai, Takeshi Kawarabayashi, Yoshiki Takao, Taisei Ohta, Yasuo Harigaya, Yasuhiro Manabe, Tatsushi Kamiya, Mikio Shoji, Koji Abe

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: To clarify the features of pure akinesia (PA) and progressive supranuclear palsy (PSP) in the early stage of disease. Methods: We investigated 15 PA and 41 PSP patients' clinical and radiologic features including head MRI, ethyl cysteinate dimmer-single photon emission-computed tomography (ECD-SPECT) and iodine-123 meta-iodobenzyl guanidine (123I-MIBG) myocardial scintigraphy. In ECD-SPECT study, cerebral blood flow (CBF) reduction was quantitatively expressed as Z-score, and that in the frontal lobe was evaluated. Results: Many PSP patients claimed falls as the initial symptom but no PA patients did. Eye movement, as well as optokinetic nystagmus elicitation, was more frequently disturbed in PSP. Dementia, dysarthria and rigidity were also more frequent in PSP than in PA. Midbrain tegmentum atrophy in head MRI was more frequently observed in PSP. CBF in the frontal lobe, especially in the frontal eye field, was significantly lower in PSP than in PA. MIBG myocardial scintigraphy showed no difference between two groups. Discussion: PA and PSP show distinct symptoms from the early stage, indicating that they are distinct disorders. The occurrence of falls and eye movement disturbance, as well as CBF reduction at the frontal eye field, is very important for distinguishing these disorders.

Original languageEnglish
Pages (from-to)860-867
Number of pages8
JournalNeurological Research
Volume30
Issue number8
DOIs
Publication statusPublished - Oct 1 2008

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Cerebrovascular Circulation
Progressive Supranuclear Palsy
Frontal Lobe
3-Iodobenzylguanidine
Myocardial Perfusion Imaging
Eye Movements
Single-Photon Emission-Computed Tomography
Tegmentum Mesencephali
Head
Optokinetic Nystagmus
Dysarthria
Guanidine
Iodine
Atrophy
Dementia

Keywords

  • Ethyl cysteinate dimmer-single photon emission-computed tomography
  • Eye movement disturbance
  • Frontal eye field
  • Progressive supranuclear palsy
  • Pure akinesia

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Differentiation of PA from early PSP with different patterns of symptoms and CBF reduction. / Kurata, Tomoko; Hayashi, Takeshi; Murakami, Tetsuro; Miyazaki, Kazunori; Morimoto, Nobutoshi; Ohta, Yasuyuki; Takehisa, Yasushi; Nagai, Makiko; Kawarabayashi, Takeshi; Takao, Yoshiki; Ohta, Taisei; Harigaya, Yasuo; Manabe, Yasuhiro; Kamiya, Tatsushi; Shoji, Mikio; Abe, Koji.

In: Neurological Research, Vol. 30, No. 8, 01.10.2008, p. 860-867.

Research output: Contribution to journalArticle

Kurata, T, Hayashi, T, Murakami, T, Miyazaki, K, Morimoto, N, Ohta, Y, Takehisa, Y, Nagai, M, Kawarabayashi, T, Takao, Y, Ohta, T, Harigaya, Y, Manabe, Y, Kamiya, T, Shoji, M & Abe, K 2008, 'Differentiation of PA from early PSP with different patterns of symptoms and CBF reduction', Neurological Research, vol. 30, no. 8, pp. 860-867. https://doi.org/10.1179/174313208X310278
Kurata, Tomoko ; Hayashi, Takeshi ; Murakami, Tetsuro ; Miyazaki, Kazunori ; Morimoto, Nobutoshi ; Ohta, Yasuyuki ; Takehisa, Yasushi ; Nagai, Makiko ; Kawarabayashi, Takeshi ; Takao, Yoshiki ; Ohta, Taisei ; Harigaya, Yasuo ; Manabe, Yasuhiro ; Kamiya, Tatsushi ; Shoji, Mikio ; Abe, Koji. / Differentiation of PA from early PSP with different patterns of symptoms and CBF reduction. In: Neurological Research. 2008 ; Vol. 30, No. 8. pp. 860-867.
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abstract = "Objective: To clarify the features of pure akinesia (PA) and progressive supranuclear palsy (PSP) in the early stage of disease. Methods: We investigated 15 PA and 41 PSP patients' clinical and radiologic features including head MRI, ethyl cysteinate dimmer-single photon emission-computed tomography (ECD-SPECT) and iodine-123 meta-iodobenzyl guanidine (123I-MIBG) myocardial scintigraphy. In ECD-SPECT study, cerebral blood flow (CBF) reduction was quantitatively expressed as Z-score, and that in the frontal lobe was evaluated. Results: Many PSP patients claimed falls as the initial symptom but no PA patients did. Eye movement, as well as optokinetic nystagmus elicitation, was more frequently disturbed in PSP. Dementia, dysarthria and rigidity were also more frequent in PSP than in PA. Midbrain tegmentum atrophy in head MRI was more frequently observed in PSP. CBF in the frontal lobe, especially in the frontal eye field, was significantly lower in PSP than in PA. MIBG myocardial scintigraphy showed no difference between two groups. Discussion: PA and PSP show distinct symptoms from the early stage, indicating that they are distinct disorders. The occurrence of falls and eye movement disturbance, as well as CBF reduction at the frontal eye field, is very important for distinguishing these disorders.",
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AU - Hayashi, Takeshi

AU - Murakami, Tetsuro

AU - Miyazaki, Kazunori

AU - Morimoto, Nobutoshi

AU - Ohta, Yasuyuki

AU - Takehisa, Yasushi

AU - Nagai, Makiko

AU - Kawarabayashi, Takeshi

AU - Takao, Yoshiki

AU - Ohta, Taisei

AU - Harigaya, Yasuo

AU - Manabe, Yasuhiro

AU - Kamiya, Tatsushi

AU - Shoji, Mikio

AU - Abe, Koji

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N2 - Objective: To clarify the features of pure akinesia (PA) and progressive supranuclear palsy (PSP) in the early stage of disease. Methods: We investigated 15 PA and 41 PSP patients' clinical and radiologic features including head MRI, ethyl cysteinate dimmer-single photon emission-computed tomography (ECD-SPECT) and iodine-123 meta-iodobenzyl guanidine (123I-MIBG) myocardial scintigraphy. In ECD-SPECT study, cerebral blood flow (CBF) reduction was quantitatively expressed as Z-score, and that in the frontal lobe was evaluated. Results: Many PSP patients claimed falls as the initial symptom but no PA patients did. Eye movement, as well as optokinetic nystagmus elicitation, was more frequently disturbed in PSP. Dementia, dysarthria and rigidity were also more frequent in PSP than in PA. Midbrain tegmentum atrophy in head MRI was more frequently observed in PSP. CBF in the frontal lobe, especially in the frontal eye field, was significantly lower in PSP than in PA. MIBG myocardial scintigraphy showed no difference between two groups. Discussion: PA and PSP show distinct symptoms from the early stage, indicating that they are distinct disorders. The occurrence of falls and eye movement disturbance, as well as CBF reduction at the frontal eye field, is very important for distinguishing these disorders.

AB - Objective: To clarify the features of pure akinesia (PA) and progressive supranuclear palsy (PSP) in the early stage of disease. Methods: We investigated 15 PA and 41 PSP patients' clinical and radiologic features including head MRI, ethyl cysteinate dimmer-single photon emission-computed tomography (ECD-SPECT) and iodine-123 meta-iodobenzyl guanidine (123I-MIBG) myocardial scintigraphy. In ECD-SPECT study, cerebral blood flow (CBF) reduction was quantitatively expressed as Z-score, and that in the frontal lobe was evaluated. Results: Many PSP patients claimed falls as the initial symptom but no PA patients did. Eye movement, as well as optokinetic nystagmus elicitation, was more frequently disturbed in PSP. Dementia, dysarthria and rigidity were also more frequent in PSP than in PA. Midbrain tegmentum atrophy in head MRI was more frequently observed in PSP. CBF in the frontal lobe, especially in the frontal eye field, was significantly lower in PSP than in PA. MIBG myocardial scintigraphy showed no difference between two groups. Discussion: PA and PSP show distinct symptoms from the early stage, indicating that they are distinct disorders. The occurrence of falls and eye movement disturbance, as well as CBF reduction at the frontal eye field, is very important for distinguishing these disorders.

KW - Ethyl cysteinate dimmer-single photon emission-computed tomography

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KW - Progressive supranuclear palsy

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