TY - JOUR
T1 - Differentiating progressive supranuclear palsy from Parkinson's disease by MRI-based dynamic cerebrospinal fluid flow
AU - Fukui, Yusuke
AU - Hishikawa, Nozomi
AU - Sato, Kota
AU - Yunoki, Taijun
AU - Kono, Syoichiro
AU - Matsuzono, Kosuke
AU - Nakano, Yumiko
AU - Ohta, Yasuyuki
AU - Yamashita, Toru
AU - Deguchi, Kentaro
AU - Abe, Koji
N1 - Funding Information:
This work was partly supported by a Grant-in-Aid for Scientific Research (B) 21390267 from the Ministry of Education, Science, Culture, and Sports of Japan and by Grants-in Aid from the Research Committee of CNS Degenerative Diseases (H23-NANJI-IPPAN-015) (I. Nakano) and grants (H. Mizusawa, M. Nishizawa, H. Sasaki, G. Sobue) from the Ministry of Health, Labour and Welfare of Japan (H23-NANJI-IPPAN-039, H25-NANJITOU-SHITEI-002).
PY - 2015/10/15
Y1 - 2015/10/15
N2 - Objective: The purpose of this study was to clarify the difference between PSP and PD from the viewpoint of dynamic cerebrospinal fluid (CSF) flow focusing on the midbrain aqueduct. Methods: Thirty-three PD patients (mean age 69.2 ± 7.9) and 35 PSP patients (mean age 70.5 ± 6.6) were included in this study. CSF flow was calculated by 15 images in an equidistant magnetic resonance imaging (MRI) sequence that was taken throughout a cardiac cycle. Results: Absolute values of the velocity (time points of 2–6 and 12–15, *p < 0.05), and the width of the CSF velocity (Vheight) (PSP, 5.1 ± 2.3 cm/s; PD, 6.0 ± 1.6 cm/s, p < 0.05) effectively discriminated PSP from PD patients. On the other hand, conventional MRI measurements discriminated well the midbrain aqueduct area (Area) (PSP, 7.7 ± 2.6 mm2; PD, 5.4 ± 1.8 mm2, p < 0.01). Two cutoff value lines (Vheight: 4.75, Area: 5.77) of the ROC curve analysis established two areas for discriminating PSP from PD. Conclusion: In the present dynamic CSF flow study, it was newly found that mean velocity of each time point and Vheight showed a more significant decline in PSP than in PD patients, providing a sensitive biomarker for differentiating them. The combination of Vheight and Area could further discriminate PSP from PD patients.
AB - Objective: The purpose of this study was to clarify the difference between PSP and PD from the viewpoint of dynamic cerebrospinal fluid (CSF) flow focusing on the midbrain aqueduct. Methods: Thirty-three PD patients (mean age 69.2 ± 7.9) and 35 PSP patients (mean age 70.5 ± 6.6) were included in this study. CSF flow was calculated by 15 images in an equidistant magnetic resonance imaging (MRI) sequence that was taken throughout a cardiac cycle. Results: Absolute values of the velocity (time points of 2–6 and 12–15, *p < 0.05), and the width of the CSF velocity (Vheight) (PSP, 5.1 ± 2.3 cm/s; PD, 6.0 ± 1.6 cm/s, p < 0.05) effectively discriminated PSP from PD patients. On the other hand, conventional MRI measurements discriminated well the midbrain aqueduct area (Area) (PSP, 7.7 ± 2.6 mm2; PD, 5.4 ± 1.8 mm2, p < 0.01). Two cutoff value lines (Vheight: 4.75, Area: 5.77) of the ROC curve analysis established two areas for discriminating PSP from PD. Conclusion: In the present dynamic CSF flow study, it was newly found that mean velocity of each time point and Vheight showed a more significant decline in PSP than in PD patients, providing a sensitive biomarker for differentiating them. The combination of Vheight and Area could further discriminate PSP from PD patients.
KW - Cerebrospinal fluid
KW - Midbrain aqueduct
KW - Neurodegenerative disorder
KW - Parkinson's disease
KW - Phase contrast-magnetic resonance imaging
KW - Progressive supranuclear palsy
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U2 - 10.1016/j.jns.2015.07.026
DO - 10.1016/j.jns.2015.07.026
M3 - Article
C2 - 26227830
AN - SCOPUS:85028241698
VL - 357
SP - 178
EP - 182
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
SN - 0022-510X
IS - 1-2
ER -