Differentiating progressive supranuclear palsy from Parkinson's disease by MRI-based dynamic cerebrospinal fluid flow

Yusuke Fukui, Nozomi Hishikawa, Kota Sato, Taijun Yunoki, Syoichiro Kono, Kosuke Matsuzono, Yumiko Nakano, Yasuyuki Ohta, Toru Yamashita, Kentaro Deguchi, Koji Abe

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Objective: The purpose of this study was to clarify the difference between PSP and PD from the viewpoint of dynamic cerebrospinal fluid (CSF) flow focusing on the midbrain aqueduct. Methods: Thirty-three PD patients (mean age 69.2 ± 7.9) and 35 PSP patients (mean age 70.5 ± 6.6) were included in this study. CSF flow was calculated by 15 images in an equidistant magnetic resonance imaging (MRI) sequence that was taken throughout a cardiac cycle. Results: Absolute values of the velocity (time points of 2–6 and 12–15, *p < 0.05), and the width of the CSF velocity (Vheight) (PSP, 5.1 ± 2.3 cm/s; PD, 6.0 ± 1.6 cm/s, p < 0.05) effectively discriminated PSP from PD patients. On the other hand, conventional MRI measurements discriminated well the midbrain aqueduct area (Area) (PSP, 7.7 ± 2.6 mm2; PD, 5.4 ± 1.8 mm2, p < 0.01). Two cutoff value lines (Vheight: 4.75, Area: 5.77) of the ROC curve analysis established two areas for discriminating PSP from PD. Conclusion: In the present dynamic CSF flow study, it was newly found that mean velocity of each time point and Vheight showed a more significant decline in PSP than in PD patients, providing a sensitive biomarker for differentiating them. The combination of Vheight and Area could further discriminate PSP from PD patients.

Original languageEnglish
Pages (from-to)178-182
Number of pages5
JournalJournal of the neurological sciences
Issue number1-2
Publication statusPublished - Oct 15 2015


  • Cerebrospinal fluid
  • Midbrain aqueduct
  • Neurodegenerative disorder
  • Parkinson's disease
  • Phase contrast-magnetic resonance imaging
  • Progressive supranuclear palsy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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