Differential Responses of Serum Gamma-glutamyltransferase to Alcohol Intake in Japanese Males

Yoko Matsuka, Da Hong Wang, Narufumi Suganuma, Kaori Imai, Satoru Ikeda, Kazuhisa Taketa, Shohei Kira

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We studied the association of γ-glutamyltransferase (GGT) and other serum markers of liver injury with daily alcohol consumption in a healthy population of 1,043 Japanese males. A positive correlation between daily alcohol consumption and biochemical markers, such as log GGT (r = 0.432), log AST (r = 0.244) or log LAP (r = 0.246), was seen in all drinkers. However, there was a negative correlation, such as log GGT (r = -0.434), log AST (r = -0.424) or log LAP (r = -0.430), in heavy drinkers who consumed more than 70 g ethanol a day. On the other hand, a positive correlation, such as log GGT (r = 0.426), log AST (r = 0.247) or log LAP (r = 0.216) was found in moderate drinkers who consumed less than 70 g ethanol a day. Interestingly, there was a tendency toward negative association between alcohol consumption and the Tokyo University ALDH2 Phenotype Screening Test (TAST) score in the heavy drinkers, and there was a tendency toward positive association between GGT and TAST score in this group. Our results suggest that there are 2 groups of drinkers, those with elevated GGT (good responders) and those with normal GGT (poor responders) despite heavy drinking.

Original languageEnglish
Pages (from-to)171-178
Number of pages8
JournalActa Medica Okayama
Volume57
Issue number4
Publication statusPublished - Aug 2003

Fingerprint

gamma-Glutamyltransferase
Alcohol Drinking
Tokyo
Alcohols
Screening
Ethanol
Biomarkers
Serum
Phenotype
Liver
Drinking
Wounds and Injuries
Population

Keywords

  • Daily alcohol consumption
  • Gamma-glutamyltransferase (GGT)
  • Good responder and poor responder

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Matsuka, Y., Wang, D. H., Suganuma, N., Imai, K., Ikeda, S., Taketa, K., & Kira, S. (2003). Differential Responses of Serum Gamma-glutamyltransferase to Alcohol Intake in Japanese Males. Acta Medica Okayama, 57(4), 171-178.

Differential Responses of Serum Gamma-glutamyltransferase to Alcohol Intake in Japanese Males. / Matsuka, Yoko; Wang, Da Hong; Suganuma, Narufumi; Imai, Kaori; Ikeda, Satoru; Taketa, Kazuhisa; Kira, Shohei.

In: Acta Medica Okayama, Vol. 57, No. 4, 08.2003, p. 171-178.

Research output: Contribution to journalArticle

Matsuka, Y, Wang, DH, Suganuma, N, Imai, K, Ikeda, S, Taketa, K & Kira, S 2003, 'Differential Responses of Serum Gamma-glutamyltransferase to Alcohol Intake in Japanese Males', Acta Medica Okayama, vol. 57, no. 4, pp. 171-178.
Matsuka Y, Wang DH, Suganuma N, Imai K, Ikeda S, Taketa K et al. Differential Responses of Serum Gamma-glutamyltransferase to Alcohol Intake in Japanese Males. Acta Medica Okayama. 2003 Aug;57(4):171-178.
Matsuka, Yoko ; Wang, Da Hong ; Suganuma, Narufumi ; Imai, Kaori ; Ikeda, Satoru ; Taketa, Kazuhisa ; Kira, Shohei. / Differential Responses of Serum Gamma-glutamyltransferase to Alcohol Intake in Japanese Males. In: Acta Medica Okayama. 2003 ; Vol. 57, No. 4. pp. 171-178.
@article{bf351aae28864a85bd0c33bbfd2a4714,
title = "Differential Responses of Serum Gamma-glutamyltransferase to Alcohol Intake in Japanese Males",
abstract = "We studied the association of γ-glutamyltransferase (GGT) and other serum markers of liver injury with daily alcohol consumption in a healthy population of 1,043 Japanese males. A positive correlation between daily alcohol consumption and biochemical markers, such as log GGT (r = 0.432), log AST (r = 0.244) or log LAP (r = 0.246), was seen in all drinkers. However, there was a negative correlation, such as log GGT (r = -0.434), log AST (r = -0.424) or log LAP (r = -0.430), in heavy drinkers who consumed more than 70 g ethanol a day. On the other hand, a positive correlation, such as log GGT (r = 0.426), log AST (r = 0.247) or log LAP (r = 0.216) was found in moderate drinkers who consumed less than 70 g ethanol a day. Interestingly, there was a tendency toward negative association between alcohol consumption and the Tokyo University ALDH2 Phenotype Screening Test (TAST) score in the heavy drinkers, and there was a tendency toward positive association between GGT and TAST score in this group. Our results suggest that there are 2 groups of drinkers, those with elevated GGT (good responders) and those with normal GGT (poor responders) despite heavy drinking.",
keywords = "Daily alcohol consumption, Gamma-glutamyltransferase (GGT), Good responder and poor responder",
author = "Yoko Matsuka and Wang, {Da Hong} and Narufumi Suganuma and Kaori Imai and Satoru Ikeda and Kazuhisa Taketa and Shohei Kira",
year = "2003",
month = "8",
language = "English",
volume = "57",
pages = "171--178",
journal = "Acta Medica Okayama",
issn = "0386-300X",
publisher = "Okayama University",
number = "4",

}

TY - JOUR

T1 - Differential Responses of Serum Gamma-glutamyltransferase to Alcohol Intake in Japanese Males

AU - Matsuka, Yoko

AU - Wang, Da Hong

AU - Suganuma, Narufumi

AU - Imai, Kaori

AU - Ikeda, Satoru

AU - Taketa, Kazuhisa

AU - Kira, Shohei

PY - 2003/8

Y1 - 2003/8

N2 - We studied the association of γ-glutamyltransferase (GGT) and other serum markers of liver injury with daily alcohol consumption in a healthy population of 1,043 Japanese males. A positive correlation between daily alcohol consumption and biochemical markers, such as log GGT (r = 0.432), log AST (r = 0.244) or log LAP (r = 0.246), was seen in all drinkers. However, there was a negative correlation, such as log GGT (r = -0.434), log AST (r = -0.424) or log LAP (r = -0.430), in heavy drinkers who consumed more than 70 g ethanol a day. On the other hand, a positive correlation, such as log GGT (r = 0.426), log AST (r = 0.247) or log LAP (r = 0.216) was found in moderate drinkers who consumed less than 70 g ethanol a day. Interestingly, there was a tendency toward negative association between alcohol consumption and the Tokyo University ALDH2 Phenotype Screening Test (TAST) score in the heavy drinkers, and there was a tendency toward positive association between GGT and TAST score in this group. Our results suggest that there are 2 groups of drinkers, those with elevated GGT (good responders) and those with normal GGT (poor responders) despite heavy drinking.

AB - We studied the association of γ-glutamyltransferase (GGT) and other serum markers of liver injury with daily alcohol consumption in a healthy population of 1,043 Japanese males. A positive correlation between daily alcohol consumption and biochemical markers, such as log GGT (r = 0.432), log AST (r = 0.244) or log LAP (r = 0.246), was seen in all drinkers. However, there was a negative correlation, such as log GGT (r = -0.434), log AST (r = -0.424) or log LAP (r = -0.430), in heavy drinkers who consumed more than 70 g ethanol a day. On the other hand, a positive correlation, such as log GGT (r = 0.426), log AST (r = 0.247) or log LAP (r = 0.216) was found in moderate drinkers who consumed less than 70 g ethanol a day. Interestingly, there was a tendency toward negative association between alcohol consumption and the Tokyo University ALDH2 Phenotype Screening Test (TAST) score in the heavy drinkers, and there was a tendency toward positive association between GGT and TAST score in this group. Our results suggest that there are 2 groups of drinkers, those with elevated GGT (good responders) and those with normal GGT (poor responders) despite heavy drinking.

KW - Daily alcohol consumption

KW - Gamma-glutamyltransferase (GGT)

KW - Good responder and poor responder

UR - http://www.scopus.com/inward/record.url?scp=0242405637&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0242405637&partnerID=8YFLogxK

M3 - Article

VL - 57

SP - 171

EP - 178

JO - Acta Medica Okayama

JF - Acta Medica Okayama

SN - 0386-300X

IS - 4

ER -