Differential Responses of Serum Gamma-glutamyltransferase to Alcohol Intake in Japanese Males

Yoko Matsuka, Da Hong Wang, Narufumi Suganuma, Kaori Imai, Satoru Ikeda, Kazuhisa Taketa, Shohei Kira

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We studied the association of γ-glutamyltransferase (GGT) and other serum markers of liver injury with daily alcohol consumption in a healthy population of 1,043 Japanese males. A positive correlation between daily alcohol consumption and biochemical markers, such as log GGT (r = 0.432), log AST (r = 0.244) or log LAP (r = 0.246), was seen in all drinkers. However, there was a negative correlation, such as log GGT (r = -0.434), log AST (r = -0.424) or log LAP (r = -0.430), in heavy drinkers who consumed more than 70 g ethanol a day. On the other hand, a positive correlation, such as log GGT (r = 0.426), log AST (r = 0.247) or log LAP (r = 0.216) was found in moderate drinkers who consumed less than 70 g ethanol a day. Interestingly, there was a tendency toward negative association between alcohol consumption and the Tokyo University ALDH2 Phenotype Screening Test (TAST) score in the heavy drinkers, and there was a tendency toward positive association between GGT and TAST score in this group. Our results suggest that there are 2 groups of drinkers, those with elevated GGT (good responders) and those with normal GGT (poor responders) despite heavy drinking.

Original languageEnglish
Pages (from-to)171-178
Number of pages8
JournalActa medica Okayama
Volume57
Issue number4
Publication statusPublished - Aug 2003

Keywords

  • Daily alcohol consumption
  • Gamma-glutamyltransferase (GGT)
  • Good responder and poor responder

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Matsuka, Y., Wang, D. H., Suganuma, N., Imai, K., Ikeda, S., Taketa, K., & Kira, S. (2003). Differential Responses of Serum Gamma-glutamyltransferase to Alcohol Intake in Japanese Males. Acta medica Okayama, 57(4), 171-178.